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mtDNAprofiler: A Web Application for the Nomenclature and Comparison of Human Mitochondrial DNA Sequences

Authors
 In Seok Yang  ;  Hwan Young Lee  ;  Woo Ick Yang  ;  Kyoung-Jin Shin 
Citation
 JOURNAL OF FORENSIC SCIENCES, Vol.58(4) : 972-980, 2013 
Journal Title
JOURNAL OF FORENSIC SCIENCES
ISSN
 0022-1198 
Issue Date
2013
MeSH
DNA, Mitochondrial/genetics* ; Humans ; Internet* ; Polymorphism, Single Nucleotide ; Sequence Analysis, DNA* ; Software* ; Terminology as Topic ; User-Computer Interface
Keywords
assembly ; concordance ; conversion ; forensic science ; mitochondrial DNA ; nomenclature ; single-nucleotide polymorphism
Abstract
Mitochondrial DNA (mtDNA) is a valuable tool in the fields of forensic, population, and medical genetics. However, recording and comparing mtDNA control region or entire genome sequences would be difficult if researchers are not familiar with mtDNA nomenclature conventions. Therefore, mtDNAprofiler, a Web application, was designed for the analysis and comparison of mtDNA sequences in a string format or as a list of mtDNA single-nucleotide polymorphisms (mtSNPs). mtDNAprofiler which comprises four mtDNA sequence-analysis tools (mtDNA nomenclature, mtDNA assembly, mtSNP conversion, and mtSNP concordance-check) supports not only the accurate analysis of mtDNA sequences via an automated nomenclature function, but also consistent management of mtSNP data via direct comparison and validity-check functions. Since mtDNAprofiler consists of four tools that are associated with key steps of mtDNA sequence analysis, mtDNAprofiler will be helpful for researchers working with mtDNA.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/1556-4029.12139/abstract
DOI
10.1111/1556-4029.12139
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Forensic Medicine (법의학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Shin, Kyoung Jin(신경진) ORCID logo https://orcid.org/0000-0002-1059-9665
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
Yang, In Seok(양인석) ORCID logo https://orcid.org/0000-0001-5224-2587
Lee, Hwan Young(이환영)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87491
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