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The frequency and impact of ROS1 rearrangement on clinical outcomes in never smokers with lung adenocarcinoma

DC Field Value Language
dc.contributor.author김주항-
dc.contributor.author김혜련-
dc.contributor.author배미경-
dc.contributor.author심효섭-
dc.contributor.author조병철-
dc.date.accessioned2014-12-18T09:04:06Z-
dc.date.available2014-12-18T09:04:06Z-
dc.date.issued2013-
dc.identifier.issn0923-7534-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87472-
dc.description.abstractBACKGROUND: To determine the frequency and predictive impact of ROS1 rearrangements on treatment outcomes in never-smoking patients with lung adenocarcinoma. PATIENTS AND METHODS: We concurrently analyzed ROS1 and ALK rearrangements and mutations in the epidermal growth factor receptor (EGFR), and KRAS in 208 never smokers with lung adenocarcinoma. ROS1 and ALK rearrangements were identified by fluorescent in situ hybridization. RESULTS: Of 208 tumors screened, 7 (3.4%) were ROS1 rearranged, and 15 (7.2%) were ALK-rearranged. CD74-ROS1 fusions were identified in two patients using reverse transcriptase-polymerase chain reaction. The frequency of ROS1 rearrangement was 5.7% (6 of 105) among EGFR/KRAS/ALK-negative patients. Patients with ROS1 rearrangement had a higher objective response rate (ORR; 60.0% versus 8.5%; P = 0.01) and a longer median progression-free survival (PFS; not reached versus 3.3 months; P = 0.008) to pemetrexed than those without ROS1/ALK rearrangement. The PFS to EGFR-tyrosine kinase inhibitors in patients harboring ROS1 rearrangement was shorter than those without ROS1/ALK rearrangement (2.5 versus 7.8 months; P = 0.01). CONCLUSIONS: The frequency of ROS1 rearrangements in clinically selected patients is higher than that reported for unselected patients, suggesting that ROS1 rearrangement is a druggable target in East-Asian never smokers with lung adenocarcinoma. Given the different treatment outcomes to conventional therapies and availability of ROS1 inhibitors, identification of ROS1 rearrangement can lead to successful treatment in ROS1-rearranged lung adenocarcinomas.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfANNALS OF ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenocarcinoma/drug therapy-
dc.subject.MESHAdenocarcinoma/genetics*-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAntigens, Differentiation, B-Lymphocyte/genetics-
dc.subject.MESHCarcinoma, Non-Small-Cell Lung/drug therapy-
dc.subject.MESHCarcinoma, Non-Small-Cell Lung/genetics*-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHCell Survival/drug effects-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHFemale-
dc.subject.MESHGene Frequency/genetics-
dc.subject.MESHGene Rearrangement/genetics-
dc.subject.MESHGlutamates/pharmacology-
dc.subject.MESHGlutamates/therapeutic use-
dc.subject.MESHGuanine/analogs & derivatives-
dc.subject.MESHGuanine/pharmacology-
dc.subject.MESHGuanine/therapeutic use-
dc.subject.MESHHistocompatibility Antigens Class II/genetics-
dc.subject.MESHHumans-
dc.subject.MESHLung Neoplasms/drug therapy-
dc.subject.MESHLung Neoplasms/genetics*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMutation/genetics-
dc.subject.MESHPemetrexed-
dc.subject.MESHProtein-Tyrosine Kinases/genetics*-
dc.subject.MESHProtein-Tyrosine Kinases/metabolism-
dc.subject.MESHProto-Oncogene Proteins/genetics*-
dc.subject.MESHProto-Oncogene Proteins/metabolism-
dc.subject.MESHProto-Oncogene Proteins p21(ras)-
dc.subject.MESHPyrazoles/pharmacology-
dc.subject.MESHPyridines/pharmacology-
dc.subject.MESHPyrimidines/pharmacology-
dc.subject.MESHQuinazolines/pharmacology-
dc.subject.MESHReceptor Protein-Tyrosine Kinases/genetics-
dc.subject.MESHReceptor Protein-Tyrosine Kinases/metabolism-
dc.subject.MESHReceptor, Epidermal Growth Factor/genetics-
dc.subject.MESHRecombinant Fusion Proteins/genetics*-
dc.subject.MESHRecombinant Fusion Proteins/metabolism-
dc.subject.MESHReverse Transcriptase Polymerase Chain Reaction-
dc.subject.MESHSmoking-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHras Proteins/genetics-
dc.titleThe frequency and impact of ROS1 rearrangement on clinical outcomes in never smokers with lung adenocarcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorH. R. Kim-
dc.contributor.googleauthorS. M. Lim-
dc.contributor.googleauthorH. J. Kim-
dc.contributor.googleauthorS. K. Hwang-
dc.contributor.googleauthorJ. K. Park-
dc.contributor.googleauthorE. Shin-
dc.contributor.googleauthorM. K. Bae-
dc.contributor.googleauthorS.-H. I. Ou-
dc.contributor.googleauthorJ. Wang-
dc.contributor.googleauthorS. S. Jewell-
dc.contributor.googleauthorD. R. Kang-
dc.contributor.googleauthorR. A. Soo-
dc.contributor.googleauthorH. Haack-
dc.contributor.googleauthorJ. H. Kim-
dc.contributor.googleauthorH. S. Shim-
dc.contributor.googleauthorB. C. Cho-
dc.identifier.doi10.1093/annonc/mdt220-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00945-
dc.contributor.localIdA01166-
dc.contributor.localIdA01792-
dc.contributor.localIdA02219-
dc.contributor.localIdA03822-
dc.relation.journalcodeJ00171-
dc.identifier.eissn1569-8041-
dc.identifier.pmid23788756-
dc.subject.keywordROS1-
dc.subject.keywordlung adenocarcinoma-
dc.subject.keywordnever smoker-
dc.subject.keywordoutcome-
dc.contributor.alternativeNameKim, Joo Hang-
dc.contributor.alternativeNameKim, Hye Ryun-
dc.contributor.alternativeNameBae, Mi Kyung-
dc.contributor.alternativeNameShim, Hyo Sup-
dc.contributor.alternativeNameCho, Byoung Chul-
dc.contributor.affiliatedAuthorKim, Joo Hang-
dc.contributor.affiliatedAuthorKim, Hye Ryun-
dc.contributor.affiliatedAuthorBae, Mi Kyung-
dc.contributor.affiliatedAuthorShim, Hyo Sup-
dc.contributor.affiliatedAuthorCho, Byoung Chul-
dc.rights.accessRightsfree-
dc.citation.volume24-
dc.citation.number9-
dc.citation.startPage2364-
dc.citation.endPage2370-
dc.identifier.bibliographicCitationANNALS OF ONCOLOGY, Vol.24(9) : 2364-2370, 2013-
dc.identifier.rimsid34249-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers

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