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Long-term Survival Outcomes Following Internal Mammary Node Irradiation in Stage II-III Breast Cancer: Results of a Large Retrospective Study With 12-Year Follow-up

DC FieldValueLanguage
dc.contributor.author금기창-
dc.contributor.author김용배-
dc.contributor.author서창옥-
dc.contributor.author이익재-
dc.contributor.author이창걸-
dc.contributor.author장지석-
dc.date.accessioned2014-12-18T09:03:51Z-
dc.date.available2014-12-18T09:03:51Z-
dc.date.issued2013-
dc.identifier.issn0360-3016-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87464-
dc.description.abstractPURPOSE: To examine the effect of internal mammary node irradiation (IMNI) on disease-free survival (DFS) and overall survival (OS) in breast cancer patients treated with modified radical mastectomy and postoperative radiation therapy. METHODS AND MATERIALS: Between 1994 and 2002, 396 patients with stage II-III breast cancer were treated with postmastectomy radiation therapy with (n=197) or without (n=199) IMNI. Patients who received neoadjuvant chemotherapy were excluded. IMNI was administered at the clinical discretion of the treating physician. Median RT dose was 50.4 Gy (range, 45.0-59.4 Gy) in 28 fractions, with inclusion of the supraclavicular fossa in 96% of patients. Adjuvant chemotherapy was administered to 99.7% of the patients and endocrine therapy to 53%. RESULTS: The median follow-up was 149 months (range, 124-202). IMNI patients had more advanced nodal stage and non-high grade tumors than those without IMNI (P<.001). Otherwise, disease and treatment characteristics were well balanced. The 10-year DFS with and without IMNI was 65% and 57%, respectively (P=.05). Multivariate analysis demonstrated that IMNI was an independent, positive predictor of DFS (hazard ratio [HR], 0.70; P=.02). Benefits of IMNI in DFS were seen most apparently in N2 patients (HR, 0.44; 95% confidence interval [CI], 0.26-0.74) and inner/central tumors (HR, 0.55; 95% CI, 0.34-0.90). The 10-year OS with and without IMNI was 72% and 66%, respectively (P=.62). The 10-year DFS and OS were 61%, and 69%, respectively. CONCLUSIONS: Internal mammary node irradiation significantly improved DFS in postmastectomy breast cancer patients. Pending long-term results from randomized trials, treatment of internal mammary nodes should be considered in postmastectomy radiation therapy.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleLong-term Survival Outcomes Following Internal Mammary Node Irradiation in Stage II-III Breast Cancer: Results of a Large Retrospective Study With 12-Year Follow-up-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학)-
dc.contributor.googleauthorJee Suk Chang-
dc.contributor.googleauthorWon Park-
dc.contributor.googleauthorYong Bae Kim-
dc.contributor.googleauthorIk Jae Lee-
dc.contributor.googleauthorKi Chang Keum-
dc.contributor.googleauthorChang Geol Lee-
dc.contributor.googleauthorDoo Ho Choi-
dc.contributor.googleauthorChang-Ok Suh-
dc.contributor.googleauthorSeung Jae Huh-
dc.identifier.doi10.1016/j.ijrobp.2013.02.037-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00744-
dc.contributor.localIdA00272-
dc.contributor.localIdA01919-
dc.contributor.localIdA03055-
dc.contributor.localIdA03240-
dc.contributor.localIdA04658-
dc.relation.journalcodeJ01157-
dc.identifier.eissn1879-355X-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0360301613004860-
dc.contributor.alternativeNameKeum, Ki Chang-
dc.contributor.alternativeNameKim, Yong Bae-
dc.contributor.alternativeNameSuh, Chang Ok-
dc.contributor.alternativeNameLee, Ik Jae-
dc.contributor.alternativeNameLee, Chang Geol-
dc.contributor.affiliatedAuthorKim, Yong Bae-
dc.contributor.affiliatedAuthorKeum, Ki Chang-
dc.contributor.affiliatedAuthorSuh, Chang Ok-
dc.contributor.affiliatedAuthorLee, Ik Jae-
dc.contributor.affiliatedAuthorLee, Chang Geol-
dc.rights.accessRightsnot free-
dc.citation.volume86-
dc.citation.number5-
dc.citation.startPage867-
dc.citation.endPage872-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Vol.86(5) : 867-872, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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