Cited 49 times in
The effects of small vessel disease and amyloid burden on neuropsychiatric symptoms: a study among patients with subcortical vascular cognitive impairments
DC Field | Value | Language |
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dc.contributor.author | 김창수 | - |
dc.date.accessioned | 2014-12-18T09:02:28Z | - |
dc.date.available | 2014-12-18T09:02:28Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0197-4580 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/87420 | - |
dc.description.abstract | Neuropsychiatric symptoms (NPS) affect the quality of life of patients with dementia and increase the burden on caregivers. We aimed to evaluate how small vessel disease (SVD) such as lacunae or white matter hyperintensities (WMH), and amyloid burden affect NPS. We recruited 127 patients with subcortical vascular cognitive impairment who were assessed with brain magnetic resonance imaging, Pittsburgh compound-B (PiB) positron emission tomography and the neuropsychiatric inventory (NPI). To explore the association between lacunae, WMH, or PiB retention ratio and NPS, we performed multivariate regression analysis after controlling for possible confounders. Each additional lacuna, especially in the frontal region, was associated with higher odds of depression, apathy, aberrant motor behavior, nighttime behavior, appetite changes, and higher score of total NPI; larger WMH volume, especially in the frontal region, was associated with higher odds of apathy and higher score of total NPI. Furthermore, for the effects of lacunae or WMH on total NPI score we set Clinical Dementia Rating Sum of Boxes as the mediator. Greater PiB retention ratio was associated with higher odds of delusions and irritability. The SVD and amyloid pathologies did not show interactive effects on NPS. Our findings suggested that SVD and amyloid burden independently affected specific NPS. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | NEUROBIOLOGY OF AGING | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Dementia, Vascular/diagnosis* | - |
dc.subject.MESH | Dementia, Vascular/psychology* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Microvessels/pathology* | - |
dc.subject.MESH | Nerve Fibers, Myelinated/pathology* | - |
dc.subject.MESH | Neuropsychological Tests* | - |
dc.subject.MESH | Plaque, Amyloid/diagnosis* | - |
dc.subject.MESH | Plaque, Amyloid/psychology* | - |
dc.subject.MESH | Prospective Studies | - |
dc.title | The effects of small vessel disease and amyloid burden on neuropsychiatric symptoms: a study among patients with subcortical vascular cognitive impairments | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Preventive Medicine (예방의학) | - |
dc.contributor.googleauthor | Hee Jin Kim | - |
dc.contributor.googleauthor | Sue J. Kang | - |
dc.contributor.googleauthor | Changsoo Kim | - |
dc.contributor.googleauthor | Geon Ha Kim | - |
dc.contributor.googleauthor | Seun Jeon | - |
dc.contributor.googleauthor | Jong Min Lee | - |
dc.contributor.googleauthor | Seung Jun Oh | - |
dc.contributor.googleauthor | Jae Seung Kim | - |
dc.contributor.googleauthor | Yearn Seong Choe | - |
dc.contributor.googleauthor | Kyung Han Lee | - |
dc.contributor.googleauthor | Young Noh | - |
dc.contributor.googleauthor | Hanna Cho | - |
dc.contributor.googleauthor | Cindy W. Yoon | - |
dc.contributor.googleauthor | Juhee Chin | - |
dc.contributor.googleauthor | Jeffrey L. Cummings | - |
dc.contributor.googleauthor | Jae Hong Lee | - |
dc.contributor.googleauthor | Duk L. Na | - |
dc.contributor.googleauthor | Sang Won Seo | - |
dc.identifier.doi | 10.1016/j.neurobiolaging.2013.01.002 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01042 | - |
dc.relation.journalcode | J02322 | - |
dc.identifier.eissn | 1558-1497 | - |
dc.identifier.pmid | 23414669 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0197458013000201 | - |
dc.subject.keyword | Aged | - |
dc.subject.keyword | Aged, 80 and over | - |
dc.subject.keyword | Dementia, Vascular/diagnosis* | - |
dc.subject.keyword | Dementia, Vascular/psychology* | - |
dc.subject.keyword | Female | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Male | - |
dc.subject.keyword | Microvessels/pathology* | - |
dc.subject.keyword | Nerve Fibers, Myelinated/pathology* | - |
dc.subject.keyword | Neuropsychological Tests* | - |
dc.subject.keyword | Plaque, Amyloid/diagnosis* | - |
dc.subject.keyword | Plaque, Amyloid/psychology* | - |
dc.subject.keyword | Prospective Studies | - |
dc.contributor.alternativeName | Kim, Chang Soo | - |
dc.contributor.affiliatedAuthor | Kim, Chang Soo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 34 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1913 | - |
dc.citation.endPage | 1920 | - |
dc.identifier.bibliographicCitation | NEUROBIOLOGY OF AGING, Vol.34(7) : 1913-1920, 2013 | - |
dc.identifier.rimsid | 34217 | - |
dc.type.rims | ART | - |
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