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Noninvasive photodetachment of stem cells on tunable conductive polymer nano thin films: selective harvesting and preserved differentiation capacity

DC FieldValueLanguage
dc.contributor.author김한수-
dc.contributor.author김현옥-
dc.date.accessioned2014-12-18T09:02:20Z-
dc.date.available2014-12-18T09:02:20Z-
dc.date.issued2013-
dc.identifier.issn1936-0851-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87416-
dc.description.abstractViable mesenchymal stem cells (MSCs) were efficiently and selectively harvested by near-infrared (NIR) light using the photothermal effect of a conductive polymer nano thin film. The poly(3,4-ethylenedioxy thiophene) (PEDOT)-coated cell culture surfaces were prepared via a simple and fast solution-casting polymerization (SCP) technique. The absorption of PEDOT thin films in the NIR region was effectively triggered cell harvesting upon exposure to an NIR source. By controlling the NIR absorption of the PEDOT film through electrochemical doping or growing PEDOT with different thin film thickness from 70 to 300 nm, the proliferation and harvesting of MSCs on the PEDOT surface were controlled quantitatively. This light-induced cell detachment method based on PEDOT films provides the temporal and spatial control of cell harvesting, as well as cell patterning. The harvested stem cells were found to be alive and well proliferated despite the use of temperature increase by NIR. More importantly, the harvested MSCs by this method preserved their intrinsic characteristics as well as multilineage differentiation capacities. This PEDOT surfaces could be used for repetitive culture and detachment of MSCs or for efficient selection or depletion of a specific subset from heterogeneous population during culture of various tissue-derived cells because there were no photodegradation and photobreakage in the PEDOT films by NIR exposure.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfACS Nano-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleNoninvasive photodetachment of stem cells on tunable conductive polymer nano thin films: selective harvesting and preserved differentiation capacity-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학)-
dc.contributor.googleauthorJungmok You-
dc.contributor.googleauthorJune Seok Heo-
dc.contributor.googleauthorJeonghun Kim-
dc.contributor.googleauthorTeahoon Park-
dc.contributor.googleauthorByeonggwan Kim-
dc.contributor.googleauthorHan-Soo Kim-
dc.contributor.googleauthorYoujeong Choi-
dc.contributor.googleauthorHyun Ok Kim-
dc.contributor.googleauthorEunkyoung Kim-
dc.identifier.doi10.1021/nn400405t-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01100-
dc.contributor.localIdA01122-
dc.relation.journalcodeJ00005-
dc.identifier.urlhttp://pubs.acs.org/doi/abs/10.1021/nn400405t-
dc.contributor.alternativeNameKim, Han Soo-
dc.contributor.alternativeNameKim, Hyun Ok-
dc.contributor.affiliatedAuthorKim, Han Soo-
dc.contributor.affiliatedAuthorKim, Hyun Ok-
dc.rights.accessRightsnot free-
dc.citation.volume7-
dc.citation.number5-
dc.citation.startPage4119-
dc.citation.endPage4128-
dc.identifier.bibliographicCitationACS Nano, Vol.7(5) : 4119-4128, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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