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Risk prediction for malignant conversion of oral epithelial dysplasia by hypoxia related protein expression

Authors
 XIANGLAN ZHANG  ;  SEONHUI HAN  ;  HYE-YEON HAN  ;  MI HEON RYU  ;  KI-YEOL KIM  ;  EUN-JOO CHOI  ;  IN-HO CHA  ;  JIN KIM 
Citation
 Pathology, Vol.45(5) : 478-483, 2013 
Journal Title
 Pathology 
ISSN
 0031-3025 
Issue Date
2013
Abstract
AIMS: Increased aerobic glycolysis is a unique finding in cancers and hypoxia-related proteins are associated with aerobic glycolysis. Therefore, we aimed to investigate whether hypoxia-related proteins can be predictive markers for malignant conversion of oral premalignant lesions with epithelial dysplasia (OED). METHODS: Expression of HIF-1α, Glut-1 and CA9 were detected in clinical samples of eight normal oral mucosa, 85 transitional areas of oral squamous cell carcinoma (OSCC) and 28 OED with or without malignant conversion using immunohistochemistry and were also comparatively detected in immortalised human oral keratinocyte (IHOK) and OSCC cell lines under hypoxia using immunoblotting. RESULTS: Sequential expression of HIF-1α, Glut-1 and CA9 was found both in transitional areas of OSCC and cell lines of IHOK and OSCC under hypoxia, supporting hypoxia-aerobic glycolysis-acidosis axis. Expression of all proteins showed significant association with malignant conversion of OED and CA9 was an independent risk factor of malignant transformation of OED. But the predictability of malignant transformation was improved when all three proteins were applied together. CONCLUSION: High expression of CA9 was an independent predictive marker of malignant conversion. Moreover, the combined application of these three proteins may be useful to assess the risk of malignant conversion of OED.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=01268031-201308000-00005&LSLINK=80&D=ovft
DOI
10.1097/PAT.0b013e3283632624
Appears in Collections:
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실)
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실)
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Oral Cancer Research Institute (구강종양연구소)
Yonsei Authors
김기열(Kim, Ki Yeol) ORCID logo https://orcid.org/0000-0001-5357-1067
김진(Kim, Jin)
장향란(Zhang, Xiang Lan)
차인호(Cha, In Ho) ORCID logo https://orcid.org/0000-0001-8259-2190
최은주(Choi, Eyn Joo)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87405
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