Cited 16 times in
FOXP3 Expression Is Related to High Ki-67 Index and Poor Prognosis in Lymph Node-Positive Breast Cancer Patients
DC Field | Value | Language |
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dc.contributor.author | 구자승 | - |
dc.contributor.author | 김민환 | - |
dc.contributor.author | 이수현 | - |
dc.date.accessioned | 2014-12-18T09:00:53Z | - |
dc.date.available | 2014-12-18T09:00:53Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0030-2414 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/87371 | - |
dc.description.abstract | Background: Recent preclinical studies have shown that Forkhead box protein 3 (FOXP3) is an important tumor suppressor gene. The clinical and prognostic implication of FOXP3 expression in breast cancer cells still remains controversial. Methods: We evaluated the FOXP3 expression status of 183 patients who underwent curative surgery for breast cancer using the immunohistochemical assay of tissue microarray. Results: We found FOXP3 expression in 51 out of 183 (27.9%) surgically resected breast cancer tumors, and 33 patients were scored as weak positive and 18 as strong positive. FOXP3-positive tumors were associated with significantly higher nuclear grade, higher histologic grade and a more negative estrogen receptor status. The FOXP3 expression level was independently associated with high Ki-67 index in a logistic regression model. In the node-positive subgroup, strong FOXP3 positivity was related to poor disease-free survival and disease-specific survival compared to FOXP3-negative patients, whereas there was no survival difference between FOXP3-negative and FOXP3-weak-positive patients. Multivariate analysis with adjustment for patient age and human epidermal growth factor receptor 2 status demonstrated significantly poor survival of FOXP3-strong-positive patients in node-positive patients. Conclusion: Our results suggest that strong FOXP3 expression in breast cancer cells is associated with poor prognosis and high Ki-67 index. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Breast Neoplasms/metabolism* | - |
dc.subject.MESH | Breast Neoplasms/mortality | - |
dc.subject.MESH | Breast Neoplasms/pathology | - |
dc.subject.MESH | Breast Neoplasms/therapy | - |
dc.subject.MESH | Carcinoma, Ductal, Breast/metabolism* | - |
dc.subject.MESH | Carcinoma, Ductal, Breast/mortality | - |
dc.subject.MESH | Carcinoma, Ductal, Breast/secondary | - |
dc.subject.MESH | Carcinoma, Ductal, Breast/therapy | - |
dc.subject.MESH | Cell Proliferation | - |
dc.subject.MESH | Chemotherapy, Adjuvant | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Forkhead Transcription Factors/metabolism* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Ki-67 Antigen/metabolism* | - |
dc.subject.MESH | Lymphatic Metastasis | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | FOXP3 Expression Is Related to High Ki-67 Index and Poor Prognosis in Lymph Node-Positive Breast Cancer Patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Min Hwan Kim | - |
dc.contributor.googleauthor | Ja Seung Koo | - |
dc.contributor.googleauthor | Soohyeon Lee | - |
dc.identifier.doi | 10.1159/000351473 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00198 | - |
dc.contributor.localId | A00482 | - |
dc.contributor.localId | A02898 | - |
dc.relation.journalcode | J02416 | - |
dc.identifier.eissn | 1423-0232 | - |
dc.identifier.pmid | 23948758 | - |
dc.identifier.url | http://www.karger.com/Article/FullText/351473 | - |
dc.subject.keyword | Forkhead box protein | - |
dc.subject.keyword | Ki-67 | - |
dc.subject.keyword | Breast cancer | - |
dc.subject.keyword | Prognosis | - |
dc.contributor.alternativeName | Koo, Ja Seung | - |
dc.contributor.alternativeName | Kim, Min Hwan | - |
dc.contributor.alternativeName | Lee, Soo Hyeon | - |
dc.contributor.affiliatedAuthor | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | Kim, Min Hwan | - |
dc.contributor.affiliatedAuthor | Lee, Soo Hyeon | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 85 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 128 | - |
dc.citation.endPage | 136 | - |
dc.identifier.bibliographicCitation | ONCOLOGY, Vol.85(2) : 128-136, 2013 | - |
dc.identifier.rimsid | 33009 | - |
dc.type.rims | ART | - |
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