Cited 34 times in
TGF-β1 T869C Polymorphism May Affect Susceptibility to Idiopathic Pulmonary Fibrosis and Disease Severity
DC Field | Value | Language |
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dc.contributor.author | 장준 | - |
dc.contributor.author | 정지예 | - |
dc.contributor.author | 강영애 | - |
dc.contributor.author | 김세규 | - |
dc.contributor.author | 김송이 | - |
dc.contributor.author | 김영삼 | - |
dc.contributor.author | 김은영 | - |
dc.contributor.author | 박무석 | - |
dc.contributor.author | 박병훈 | - |
dc.contributor.author | 손지영 | - |
dc.contributor.author | 심효섭 | - |
dc.contributor.author | 임주은 | - |
dc.date.accessioned | 2014-12-18T09:00:30Z | - |
dc.date.available | 2014-12-18T09:00:30Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0341-2040 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/87360 | - |
dc.description.abstract | BACKGROUND: Transforming growth factor-β1 (TGF-β1) is a key cytokine that plays a critical role in idiopathic pulmonary fibrosis (IPF). The genotypes of T869C polymorphism may be associated with the susceptibility to fibrotic lung disease. METHODS: We investigated a single-nucleotide polymorphism at exon 1 nucleotide position 29 (T → C) of the TGF-β1 gene. Eighty-five healthy controls and 85 subjects with surgically confirmed IPF were investigated using polymerase chain reaction and restriction enzyme fragment length polymorphism techniques. RESULTS: The IPF patients consisted of 55 men and 30 women. The mean age was 61 ± 8 years. Fifty-one (60 %) of the 85 IPF patients were smokers and 34 were nonsmokers. The distribution of genotypes between IPF patients and controls was significantly different (IPF: TT 43.5 % and TC or CC 56.5 %; controls: TT 27.1 % and TC or CC 72.9 %, p = 0.037). TT genotype was significantly associated with decreased PaO2 and increased D(A-a)O2 upon initial diagnosis (p = 0.006 and 0.009, respectively). There was a positive association between TT genotype and IPF development (odds ratio [OR] = 2.1, 95 % confidence interval [CI] = 1.1-4.0, p = 0.028). CONCLUSIONS: This study suggests that the TGF-β1 gene T869C polymorphism may affect susceptibility to IPF in Koreans. Larger studies are required to confirm the genetic association of TGF-β1 gene polymorphism and IPF. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | LUNG | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Asian Continental Ancestry Group/genetics | - |
dc.subject.MESH | Chi-Square Distribution | - |
dc.subject.MESH | Exons | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Frequency | - |
dc.subject.MESH | Genetic Predisposition to Disease | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Idiopathic Pulmonary Fibrosis/diagnosis | - |
dc.subject.MESH | Idiopathic Pulmonary Fibrosis/ethnology | - |
dc.subject.MESH | Idiopathic Pulmonary Fibrosis/genetics* | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Logistic Models | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Odds Ratio | - |
dc.subject.MESH | Phenotype | - |
dc.subject.MESH | Polymorphism, Single Nucleotide* | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Assessment | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Severity of Illness Index | - |
dc.subject.MESH | Transforming Growth Factor beta1/genetics* | - |
dc.title | TGF-β1 T869C Polymorphism May Affect Susceptibility to Idiopathic Pulmonary Fibrosis and Disease Severity | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Ji Young Son | - |
dc.contributor.googleauthor | Song Yee Kim | - |
dc.contributor.googleauthor | Sang Ho Cho | - |
dc.contributor.googleauthor | Hyo Sub Shim | - |
dc.contributor.googleauthor | Ji-Ye Jung | - |
dc.contributor.googleauthor | Eun Young Kim | - |
dc.contributor.googleauthor | Ju Eun Lim | - |
dc.contributor.googleauthor | Byung Hoon Park | - |
dc.contributor.googleauthor | Young Ae Kang | - |
dc.contributor.googleauthor | Young Sam Kim | - |
dc.contributor.googleauthor | Se Kyu Kim | - |
dc.contributor.googleauthor | Joon Chang | - |
dc.contributor.googleauthor | Moo Suk Park | - |
dc.identifier.doi | 10.1007/s00408-012-9447-z | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03472 | - |
dc.contributor.localId | A03735 | - |
dc.contributor.localId | A00057 | - |
dc.contributor.localId | A00602 | - |
dc.contributor.localId | A00626 | - |
dc.contributor.localId | A00707 | - |
dc.contributor.localId | A01457 | - |
dc.contributor.localId | A01478 | - |
dc.contributor.localId | A01996 | - |
dc.contributor.localId | A02219 | - |
dc.contributor.localId | A03407 | - |
dc.contributor.localId | A00811 | - |
dc.relation.journalcode | J02173 | - |
dc.identifier.eissn | 1432-1750 | - |
dc.identifier.pmid | 23344525 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs00408-012-9447-z | - |
dc.subject.keyword | Pulmonary fibrosis | - |
dc.subject.keyword | Idiopathic | - |
dc.subject.keyword | Transforming growth factor-β1 | - |
dc.subject.keyword | Polymorphism | - |
dc.contributor.alternativeName | Chang, Joon | - |
dc.contributor.alternativeName | Jung, Ji Ye | - |
dc.contributor.alternativeName | Kang, Young Ae | - |
dc.contributor.alternativeName | Kim, Se Kyu | - |
dc.contributor.alternativeName | Kim, Song Yi | - |
dc.contributor.alternativeName | Kim, Young Sam | - |
dc.contributor.alternativeName | Kim, Eun Young | - |
dc.contributor.alternativeName | Park, Moo Suk | - |
dc.contributor.alternativeName | Park, Byung Hoon | - |
dc.contributor.alternativeName | Son, Ji Young | - |
dc.contributor.alternativeName | Shim, Hyo Sup | - |
dc.contributor.alternativeName | Lim, Ju Eun | - |
dc.contributor.affiliatedAuthor | Chang, Joon | - |
dc.contributor.affiliatedAuthor | Jung, Ji Ye | - |
dc.contributor.affiliatedAuthor | Kang, Young Ae | - |
dc.contributor.affiliatedAuthor | Kim, Se Kyu | - |
dc.contributor.affiliatedAuthor | Kim, Song Yi | - |
dc.contributor.affiliatedAuthor | Kim, Young Sam | - |
dc.contributor.affiliatedAuthor | Park, Moo Suk | - |
dc.contributor.affiliatedAuthor | Park, Byung Hoon | - |
dc.contributor.affiliatedAuthor | Son, Ji Young | - |
dc.contributor.affiliatedAuthor | Shim, Hyo Sup | - |
dc.contributor.affiliatedAuthor | Lim, Ju Eun | - |
dc.contributor.affiliatedAuthor | Kim, Eun Young | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 191 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 199 | - |
dc.citation.endPage | 205 | - |
dc.identifier.bibliographicCitation | LUNG, Vol.191(2) : 199-205, 2013 | - |
dc.identifier.rimsid | 33002 | - |
dc.type.rims | ART | - |
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