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Comparison Between a β-Tricalcium Phosphate and an Absorbable Collagen Sponge Carrier Technology for rhGDF-5–Stimulated Periodontal Wound Healing/Regeneration

Authors
 Young-Taek Kim  ;  Ulf M.E. Wikesjö  ;  Ui-Won Jung  ;  Jung-Seok Lee  ;  Tae-Gyun Kim  ;  Chong-Kwan Kim 
Citation
 JOURNAL OF PERIODONTOLOGY, Vol.84(6) : 812-820, 2013 
Journal Title
 JOURNAL OF PERIODONTOLOGY 
ISSN
 0022-3492 
Issue Date
2013
MeSH
Alveolar Bone Loss/pathology ; Alveolar Bone Loss/surgery* ; Animals ; Bone Marrow/drug effects ; Bone Marrow/pathology ; Bone Regeneration/drug effects ; Calcium Phosphates/chemistry* ; Cementogenesis/drug effects ; Collagen/chemistry* ; Disease Models, Animal ; Dogs ; Growth Differentiation Factor 5/therapeutic use* ; Guided Tissue Regeneration, Periodontal/methods* ; Humans ; Male ; Mandible/pathology ; Mandible/surgery ; Osteogenesis/drug effects ; Periodontal Ligament/drug effects ; Periodontal Ligament/pathology ; Recombinant Proteins ; Surgical Flaps ; Time Factors ; Tissue Engineering/methods ; Tissue Scaffolds/chemistry*
Keywords
Alveolar Bone Loss/pathology ; Alveolar Bone Loss/surgery* ; Animals ; Bone Marrow/drug effects ; Bone Marrow/pathology ; Bone Regeneration/drug effects ; Calcium Phosphates/chemistry* ; Cementogenesis/drug effects ; Collagen/chemistry* ; Disease Models, Animal ; Dogs ; Growth Differentiation Factor 5/therapeutic use* ; Guided Tissue Regeneration, Periodontal/methods* ; Humans ; Male ; Mandible/pathology ; Mandible/surgery ; Osteogenesis/drug effects ; Periodontal Ligament/drug effects ; Periodontal Ligament/pathology ; Recombinant Proteins ; Surgical Flaps ; Time Factors ; Tissue Engineering/methods ; Tissue Scaffolds/chemistry*
Abstract
Background: The objective of this study is to compare a candidate β-tricalcium phosphate (β-TCP) carrier technology with the absorbable collagen sponge (ACS) benchmark to support recombinant human growth/differentiation factor-5 (rhGDF-5)–stimulated periodontal wound healing/regeneration. Methods: Routine, bilateral, critical-size (5-mm), 1-wall, intrabony periodontal defects were surgically created in the mandibular premolar region in 10 beagle dogs. Five animals received rhGDF-5/β-TCP and five animals received rhGDF-5/ACS, with a total of 20 μg rhGDF-5 per defect. The animals were euthanized for histologic and histometric analyses at 8 weeks postsurgery. Results: Both rhGDF-5/ACS and rhGDF-5/β-TCP stimulated the formation of functionally oriented periodontal ligament, cellular mixed fiber cementum, and woven/lamellar bone. Bone regeneration (height and area) was significantly greater for the rhGDF-5/β-TCP construct than for the rhGDF-5/ACS (3.26 ± 0.30 mm versus 2.22 ± 0.82 mm, P <0.01; and 10.45 ± 2.26 mm2 versus 5.62 ± 2.39 mm2, P <0.01, respectively). Cementum formation ranged from 3.83 ± 0.73 mm to 3.03 ± 1.18 mm without significant differences between groups. Root resorption/ankylosis was not observed. Conclusions: The β-TCP carrier technology significantly enhanced rhGDF-5–stimulated bone formation compared with the ACS benchmark in this discriminating periodontal defect model. The structural integrity of the β-TCP carrier, preventing compression while providing a framework for bone ingrowth, may account for the observed results.
Full Text
http://www.joponline.org/doi/abs/10.1902/jop.2012.120307?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed&
DOI
10.1902/jop.2012.120307
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chong Kwan(김종관)
Lee, Jung Seok(이중석) ORCID logo https://orcid.org/0000-0003-1276-5978
Jung, Ui Won(정의원) ORCID logo https://orcid.org/0000-0001-6371-4172
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87252
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