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Immunogenicity and Safety of 13-Valent Pneumococcal Conjugate Vaccine Given to Korean Children Receiving Routine Pediatric Vaccines

DC Field Value Language
dc.contributor.author김동수-
dc.contributor.author김기환-
dc.date.accessioned2014-12-18T08:56:25Z-
dc.date.available2014-12-18T08:56:25Z-
dc.date.issued2013-
dc.identifier.issn0891-3668-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87233-
dc.description.abstractBACKGROUND: The immunogenicity and safety of 13-valent and 7-valent pneumococcal conjugate vaccines (PCV13 and PCV7) were compared when administered with routine vaccines in Korea. METHODS: Healthy infants (n = 180) were randomly assigned (1:1) to receive PCV13 or PCV7 at 2, 4, 6 (infant series) and 12 months (toddler dose). Immune responses 1 month after the infant series and toddler dose were measured by enzyme-linked immunosorbent assay and opsonophagocytic activity (OPA) assay. IgG antibody geometric mean concentrations and OPA functional antibody geometric mean titers were calculated. Safety was assessed. RESULTS: After the infant series, for the 7 common serotypes, proportions of responders with IgG concentrations ≥0.35 µg/mL were comparable (≥97.6%) between groups; IgG geometric mean concentrations and OPA geometric mean titers were generally similar, but tended to be lower in the PCV13 group for some serotypes. For the 6 serotypes unique to PCV13, IgG geometric mean concentrations and OPA geometric mean titers were notably higher in the PCV13 group. Importantly, although PCV7 elicited IgG antibodies to PCV13 serotypes 5 and 19A, OPA responses were minimal, whereas serotype 6A elicited both IgG and OPA responses. These observations are consistent with at least some protection by PCV7 against 6A-mediated invasive pneumococcal disease, but no cross-protection for serotypes 5 and 19A. The toddler dose elicited higher IgG and OPA responses than postinfant series responses for most serotypes; however, for serotypes 3 and 14 only OPA responses were increased posttoddler dose. Vaccine safety profiles were similar. CONCLUSIONS: PCV13 is safe and immunogenic in Korean children. PCV13 should provide broader protection than PCV7.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfPEDIATRIC INFECTIOUS DISEASE JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAntibodies, Bacterial/blood-
dc.subject.MESHAsian Continental Ancestry Group-
dc.subject.MESHDouble-Blind Method-
dc.subject.MESHDrug-Related Side Effects and Adverse Reactions/epidemiology-
dc.subject.MESHDrug-Related Side Effects and Adverse Reactions/pathology-
dc.subject.MESHEnzyme-Linked Immunosorbent Assay-
dc.subject.MESHFemale-
dc.subject.MESHHeptavalent Pneumococcal Conjugate Vaccine-
dc.subject.MESHHumans-
dc.subject.MESHImmunoglobulin G/blood-
dc.subject.MESHInfant-
dc.subject.MESHInfant, Newborn-
dc.subject.MESHKorea-
dc.subject.MESHMale-
dc.subject.MESHOpsonin Proteins/blood-
dc.subject.MESHPhagocytosis-
dc.subject.MESHPneumococcal Infections/immunology-
dc.subject.MESHPneumococcal Infections/prevention & control*-
dc.subject.MESHPneumococcal Vaccines/administration & dosage-
dc.subject.MESHPneumococcal Vaccines/adverse effects*-
dc.subject.MESHPneumococcal Vaccines/immunology*-
dc.titleImmunogenicity and Safety of 13-Valent Pneumococcal Conjugate Vaccine Given to Korean Children Receiving Routine Pediatric Vaccines-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학)-
dc.contributor.googleauthorDong Soo Kim-
dc.contributor.googleauthorSeon Hee Shin-
dc.contributor.googleauthorHoan Jong Lee-
dc.contributor.googleauthorYoung Jin Hong-
dc.contributor.googleauthorSoo Young Lee-
dc.contributor.googleauthorKyong Min Choi-
dc.contributor.googleauthorChi Eun Oh-
dc.contributor.googleauthorKi Hwan Kim-
dc.contributor.googleauthorChristine Juergens-
dc.contributor.googleauthorScott Patterson-
dc.contributor.googleauthorPeter C. Giardina-
dc.contributor.googleauthorWilliam C. Gruber-
dc.contributor.googleauthorEmilio A. Emini-
dc.contributor.googleauthorDaniel A. Scott-
dc.identifier.doi10.1097/INF.0b013e3182748bb6-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00344-
dc.contributor.localIdA00405-
dc.relation.journalcodeJ02487-
dc.identifier.eissn1532-0987-
dc.identifier.pmid23011012-
dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00006454-201303000-00017&LSLINK=80&D=ovft-
dc.subject.keyword13-valent pneumococcal conjugate vaccine-
dc.subject.keywordKorea-
dc.subject.keywordimmunogenicity-
dc.subject.keywordsafety-
dc.subject.keywordpediatric-
dc.contributor.alternativeNameKim, Dong Soo-
dc.contributor.alternativeNameKim, Ki Hwan-
dc.contributor.affiliatedAuthorKim, Ki Hwan-
dc.contributor.affiliatedAuthorKim, Dong Soo-
dc.rights.accessRightsnot free-
dc.citation.volume32-
dc.citation.number3-
dc.citation.startPage266-
dc.citation.endPage273-
dc.identifier.bibliographicCitationPEDIATRIC INFECTIOUS DISEASE JOURNAL, Vol.32(3) : 266-273, 2013-
dc.identifier.rimsid32916-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

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