Cited 10 times in
Stepwise Treatment Using Corticosteroids Alone and in Combination with Cyclosporine in Korean Patients with Idiopathic Membranous Nephropathy
DC Field | Value | Language |
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dc.contributor.author | 박정탁 | - |
dc.contributor.author | 오형중 | - |
dc.contributor.author | 유태현 | - |
dc.contributor.author | 이미정 | - |
dc.contributor.author | 최규헌 | - |
dc.contributor.author | 한승혁 | - |
dc.contributor.author | 한재현 | - |
dc.contributor.author | 강신욱 | - |
dc.contributor.author | 구향모 | - |
dc.contributor.author | 김형래 | - |
dc.contributor.author | 도화미 | - |
dc.date.accessioned | 2014-12-18T08:55:17Z | - |
dc.date.available | 2014-12-18T08:55:17Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/87197 | - |
dc.description.abstract | PURPOSE: We undertook an observational study to investigate the effects of immunosuppressive treatment on proteinuria and renal function in 179 Korean idiopathic membranous nephropathy patients with nephrotic syndrome. MATERIALS AND METHODS: The primary outcome was regarded as the first appearance of remission and the secondary outcomes as a decline in estimated glomerular filtration rate (eGFR) >50% or initiation of dialysis, and all-cause mortality. Seventy-two (40.2%) and 50 (27.9%) patients were treated with corticosteroids alone (C) and corticosteroids plus cyclosporine (C+C), respectively, whereas 57 (31.8%) did not receive immunosuppressants (NTx). Cyclosporine was added if there was no reduction in proteinuria of >50% from baseline by corticosteroids alone within 3 months. RESULTS: There were no differences in baseline renal function and the amount of proteinuria among the three groups. Overall, complete remission (CR) was achieved in 88 (72.1%) patients by immunosuppressants. In a multivariate analysis adjusted for covariates associated with adverse renal outcome, the probability of reaching CR was significantly higher in the C [hazard ratio (HR), 4.09; p<0.001] and C+C groups (HR, 2.57; p=0.003) than in the NTx group. Kaplan-Meier analysis revealed that 5-year CR rates of C, C+C, and NTx groups were 88.5%, 86.2%, and 56.7% (p<0.001). Ten-year event-free rates for the secondary endpoints in these three groups were 91.7%, 79.9%, and 57.2% (p=0.01). CONCLUSION: Immunosuppressive treatment was effective in inducing remission and preserving renal function in these patients. Therefore, stepwise treatment using corticosteroids alone and in combination with cyclosporine is warranted in these patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adrenal Cortex Hormones/adverse effects | - |
dc.subject.MESH | Adrenal Cortex Hormones/therapeutic use* | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Cyclosporine/adverse effects | - |
dc.subject.MESH | Cyclosporine/therapeutic use* | - |
dc.subject.MESH | Drug Administration Schedule | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glomerular Filtration Rate/drug effects | - |
dc.subject.MESH | Glomerulonephritis, Membranous/drug therapy* | - |
dc.subject.MESH | Glomerulonephritis, Membranous/mortality | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunosuppressive Agents/adverse effects | - |
dc.subject.MESH | Immunosuppressive Agents/therapeutic use* | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Kidney/drug effects | - |
dc.subject.MESH | Kidney/physiology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Proteinuria/chemically induced | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Stepwise Treatment Using Corticosteroids Alone and in Combination with Cyclosporine in Korean Patients with Idiopathic Membranous Nephropathy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Dong Ho Shin | - |
dc.contributor.googleauthor | Mi Jung Lee | - |
dc.contributor.googleauthor | Hyung Jung Oh | - |
dc.contributor.googleauthor | Hyang Mo Koo | - |
dc.contributor.googleauthor | Fa Mee Doh | - |
dc.contributor.googleauthor | Hyoung Rae Kim | - |
dc.contributor.googleauthor | Jae Hyun Han | - |
dc.contributor.googleauthor | Jung Tak Park | - |
dc.contributor.googleauthor | Seung Hyeok Han | - |
dc.contributor.googleauthor | Kyu Hun Choi | - |
dc.contributor.googleauthor | Tae-Hyun Yoo | - |
dc.contributor.googleauthor | Shin-Wook Kang | - |
dc.identifier.doi | 10.3349/ymj.2013.54.4.973 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01654 | - |
dc.contributor.localId | A02097 | - |
dc.contributor.localId | A02417 | - |
dc.contributor.localId | A02526 | - |
dc.contributor.localId | A04043 | - |
dc.contributor.localId | A04304 | - |
dc.contributor.localId | A04320 | - |
dc.contributor.localId | A00053 | - |
dc.contributor.localId | A00203 | - |
dc.contributor.localId | A01147 | - |
dc.contributor.localId | A01315 | - |
dc.contributor.localId | A02773 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 23709434 | - |
dc.subject.keyword | Corticosteroids | - |
dc.subject.keyword | cyclosporine | - |
dc.subject.keyword | idiopathic membranous nephropathy | - |
dc.subject.keyword | nephrotic syndrome | - |
dc.subject.keyword | remission | - |
dc.contributor.alternativeName | Park, Jung Tak | - |
dc.contributor.alternativeName | Shin, Dong Ho | - |
dc.contributor.alternativeName | Oh, Hyung Jung | - |
dc.contributor.alternativeName | Yoo, Tae Hyun | - |
dc.contributor.alternativeName | Lee, Mi Jung | - |
dc.contributor.alternativeName | Choi, Kyu Hun | - |
dc.contributor.alternativeName | Han, Seung Hyeok | - |
dc.contributor.alternativeName | Han, Jae Hyun | - |
dc.contributor.alternativeName | Kang, Shin Wook | - |
dc.contributor.alternativeName | Koo, Hyang Mo | - |
dc.contributor.alternativeName | Kim, Hyoung Rae | - |
dc.contributor.alternativeName | Doh, Fa Mee | - |
dc.contributor.affiliatedAuthor | Park, Jung Tak | - |
dc.contributor.affiliatedAuthor | Shin, Dong Ho | - |
dc.contributor.affiliatedAuthor | Oh, Hyung Jung | - |
dc.contributor.affiliatedAuthor | Yoo, Tae Hyun | - |
dc.contributor.affiliatedAuthor | Choi, Kyu Hun | - |
dc.contributor.affiliatedAuthor | Han, Seung Hyeok | - |
dc.contributor.affiliatedAuthor | Han, Jae Hyun | - |
dc.contributor.affiliatedAuthor | Kang, Shin Wook | - |
dc.contributor.affiliatedAuthor | Koo, Hyang Mo | - |
dc.contributor.affiliatedAuthor | Kim, Hyoung Rae | - |
dc.contributor.affiliatedAuthor | Doh, Fa Mee | - |
dc.contributor.affiliatedAuthor | Lee, Mi Jung | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 54 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 973 | - |
dc.citation.endPage | 982 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.54(4) : 973-982, 2013 | - |
dc.identifier.rimsid | 32893 | - |
dc.type.rims | ART | - |
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