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Identification of genetic susceptibility loci for colorectal tumors in a genome-wide meta-analysis

DC Field Value Language
dc.contributor.author지선하-
dc.date.accessioned2014-12-18T08:54:57Z-
dc.date.available2014-12-18T08:54:57Z-
dc.date.issued2013-
dc.identifier.issn0016-5085-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87187-
dc.description.abstractBACKGROUND & AIMS: Heritable factors contribute to the development of colorectal cancer. Identifying the genetic loci associated with colorectal tumor formation could elucidate the mechanisms of pathogenesis. METHODS: We conducted a genome-wide association study that included 14 studies, 12,696 cases of colorectal tumors (11,870 cancer, 826 adenoma), and 15,113 controls of European descent. The 10 most statistically significant, previously unreported findings were followed up in 6 studies; these included 3056 colorectal tumor cases (2098 cancer, 958 adenoma) and 6658 controls of European and Asian descent. RESULTS: Based on the combined analysis, we identified a locus that reached the conventional genome-wide significance level at less than 5.0 × 10(-8): an intergenic region on chromosome 2q32.3, close to nucleic acid binding protein 1 (most significant single nucleotide polymorphism: rs11903757; odds ratio [OR], 1.15 per risk allele; P = 3.7 × 10(-8)). We also found evidence for 3 additional loci with P values less than 5.0 × 10(-7): a locus within the laminin gamma 1 gene on chromosome 1q25.3 (rs10911251; OR, 1.10 per risk allele; P = 9.5 × 10(-8)), a locus within the cyclin D2 gene on chromosome 12p13.32 (rs3217810 per risk allele; OR, 0.84; P = 5.9 × 10(-8)), and a locus in the T-box 3 gene on chromosome 12q24.21 (rs59336; OR, 0.91 per risk allele; P = 3.7 × 10(-7)). CONCLUSIONS: In a large genome-wide association study, we associated polymorphisms close to nucleic acid binding protein 1 (which encodes a DNA-binding protein involved in DNA repair) with colorectal tumor risk. We also provided evidence for an association between colorectal tumor risk and polymorphisms in laminin gamma 1 (this is the second gene in the laminin family to be associated with colorectal cancers), cyclin D2 (which encodes for cyclin D2), and T-box 3 (which encodes a T-box transcription factor and is a target of Wnt signaling to β-catenin). The roles of these genes and their products in cancer pathogenesis warrant further investigation.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfGASTROENTEROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAge Distribution-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHColorectal Neoplasms/epidemiology-
dc.subject.MESHColorectal Neoplasms/genetics*-
dc.subject.MESHCyclin D2/genetics*-
dc.subject.MESHDNA-Binding Proteins/genetics-
dc.subject.MESHFemale-
dc.subject.MESHGenetic Loci/genetics*-
dc.subject.MESHGenetic Predisposition to Disease/epidemiology*-
dc.subject.MESHGenome-Wide Association Study-
dc.subject.MESHHumans-
dc.subject.MESHIncidence-
dc.subject.MESHLaminin/genetics-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPolymorphism, Single Nucleotide-
dc.subject.MESHPrognosis-
dc.subject.MESHRisk Assessment-
dc.subject.MESHSex Distribution-
dc.subject.MESHT-Box Domain Proteins/genetics-
dc.titleIdentification of genetic susceptibility loci for colorectal tumors in a genome-wide meta-analysis-
dc.typeArticle-
dc.contributor.collegeGraduate School of Public Health (보건대학원)-
dc.contributor.departmentGraduate School of Public Health (보건대학원)-
dc.contributor.googleauthorUlrike Peters-
dc.contributor.googleauthorShuo Jiao-
dc.contributor.googleauthorFredrick R. Schumacher-
dc.contributor.googleauthorCarolyn M. Hutter-
dc.contributor.googleauthorAaron K. Aragaki-
dc.contributor.googleauthorJohn A. Baron-
dc.contributor.googleauthorSonja I. Berndt-
dc.contributor.googleauthorStéphane Bézieau-
dc.contributor.googleauthorHermann Brenner-
dc.contributor.googleauthorKatja Butterbach-
dc.contributor.googleauthorBette J. Caan-
dc.contributor.googleauthorPeter T. Campbell-
dc.contributor.googleauthorChristopher S. Carlson-
dc.contributor.googleauthorGraham Casey-
dc.contributor.googleauthorAndrew T. Chan-
dc.contributor.googleauthorJenny Chang-Claude-
dc.contributor.googleauthorStephen J. Chanock-
dc.contributor.googleauthorLin S. Chen-
dc.contributor.googleauthorGerhard A. Coetzee-
dc.contributor.googleauthorSimon G. Coetzee-
dc.contributor.googleauthorDavid V. Conti-
dc.contributor.googleauthorKeith R. Curtis-
dc.contributor.googleauthorDavid Duggan-
dc.contributor.googleauthorTodd Edwards-
dc.contributor.googleauthorCharles S. Fuchs-
dc.contributor.googleauthorSteven Gallinger-
dc.contributor.googleauthorEdward L. Giovannucci-
dc.contributor.googleauthorStephanie M. Gogarten-
dc.contributor.googleauthorStephen B. Gruber-
dc.contributor.googleauthorRobert W. Haile-
dc.contributor.googleauthorTabitha A. Harrison-
dc.contributor.googleauthorRichard B. Hayes-
dc.contributor.googleauthorBrian E. Henderson-
dc.contributor.googleauthorMichael Hoffmeister-
dc.contributor.googleauthorJohn L. Hopper-
dc.contributor.googleauthorThomas J. Hudson-
dc.contributor.googleauthorDavid J. Hunter-
dc.contributor.googleauthorRebecca D. Jackson-
dc.contributor.googleauthorSun Ha Jee-
dc.contributor.googleauthorMark A. Jenkins-
dc.contributor.googleauthorWei-Hua Jia-
dc.contributor.googleauthorLaurence N. Kolonel-
dc.contributor.googleauthorCharles Kooperberg-
dc.contributor.googleauthorSébastien Küry-
dc.contributor.googleauthorAndrea Z. Lacroix-
dc.contributor.googleauthorCathy C. Laurie-
dc.contributor.googleauthorCecelia A. Laurie-
dc.contributor.googleauthorLoic Le Marchand-
dc.contributor.googleauthorMathieu Lemire-
dc.contributor.googleauthorDavid Levine-
dc.contributor.googleauthorNoralane M. Lindor-
dc.contributor.googleauthorYan Liu-
dc.contributor.googleauthorJing Ma-
dc.contributor.googleauthorKaren W. Makar-
dc.contributor.googleauthorKeitaro Matsuo-
dc.contributor.googleauthorPolly A. Newcomb-
dc.contributor.googleauthorJohn D. Potter-
dc.contributor.googleauthorRoss L. Prentice-
dc.contributor.googleauthorConghui Qu-
dc.contributor.googleauthorThomas Rohan-
dc.contributor.googleauthorStephanie A. Rosse-
dc.contributor.googleauthorRobert E. Schoen-
dc.contributor.googleauthorDaniela Seminara-
dc.contributor.googleauthorMartha Shrubsole-
dc.contributor.googleauthorXiao-Ou Shu-
dc.contributor.googleauthorMartha L. Slattery-
dc.contributor.googleauthorDarin Taverna-
dc.contributor.googleauthorStephen N. Thibodeau-
dc.contributor.googleauthorCornelia M. Ulrich-
dc.contributor.googleauthorEmily White-
dc.contributor.googleauthorYongbing Xiang-
dc.contributor.googleauthorBrent W. Zanke-
dc.contributor.googleauthorYi-Xin Zeng-
dc.contributor.googleauthorBen Zhang-
dc.contributor.googleauthorWei Zheng-
dc.contributor.googleauthorLi Hsu-
dc.identifier.doi10.1053/j.gastro.2012.12.020-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03965-
dc.relation.journalcodeJ00917-
dc.identifier.eissn1528-0012-
dc.identifier.pmid23266556-
dc.subject.keywordColon Cancer-
dc.subject.keywordGenetics-
dc.subject.keywordRisk Factors-
dc.subject.keywordSNP-
dc.contributor.alternativeNameJee, Sun Ha-
dc.contributor.affiliatedAuthorJee, Sun Ha-
dc.rights.accessRightsfree-
dc.citation.volume144-
dc.citation.number4-
dc.citation.startPage799-
dc.citation.endPage807-
dc.identifier.bibliographicCitationGASTROENTEROLOGY, Vol.144(4) : 799-807, 2013-
dc.identifier.rimsid32544-
dc.type.rimsART-
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers

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