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Cited 4 times in

Chemoradiotherapy in squamous cell carcinoma of the anal canal: a single institution experience

DC FieldValueLanguage
dc.contributor.author금기창-
dc.contributor.author금웅섭-
dc.contributor.author안중배-
dc.contributor.author이창걸-
dc.contributor.author장지석-
dc.date.accessioned2014-12-18T08:54:36Z-
dc.date.available2014-12-18T08:54:36Z-
dc.date.issued2013-
dc.identifier.issn2234-1900-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87176-
dc.description.abstractPURPOSE: We reviewed the treatment outcomes and prognostic factors for patients with anal canal carcinoma who were treated with curative intent chemoradiotherapy (CRT) at Severance Hospital from 2005 to 2011. MATERIALS AND METHODS: Data for 38 eligible patients treated during this period were reviewed. All patients were treated with curative intent using radiotherapy (RT) with (n = 35) or without concomitant chemotherapy (n = 3). Among 35 patients who received CRT, most of the chemotherapeutic regimens were either 5-fluorouracil (5-FU) plus mitomycin C (23 patients) or 5-FU plus cisplatin (10 patients). Recurrence-free survival (RFS), colostomy-free survival (CFS), overall survival (OS), and locoregional control (LRC) rates were calculated using the Kaplan-Meier method and survival between subgroups were compared using the log-rank test. Cox's proportional hazard model was used for multivariate analysis. RESULTS: Over a median follow-up period of 44 months (range, 11 to 96 months), 3-year RFS, CFS, OS, and LRC were 80%, 79%, 85%, and 92%, respectively. In multivariate analysis, tumor size >4 cm was an independent predicting factor for poorer RFS (hazard ratio [HR], 6.35; 95% confidence interval [CI], 1.42 to 28.5; p = 0.006) and CFS (HR, 6.25; 95% CI, 1.39-28.0; p = 0.017), while the presence of external iliac lymph node metastasis was an independent prognosticator for poorer OS (HR, 9.32; 95% CI, 1.24 to 70.3; p = 0.030). No treatment-related colostomies or deaths occurred during or after treatment. CONCLUSION: Curative intent CRT resulted in excellent outcomes that were comparable to outcomes in previous randomized trials. No severe treatment-related toxicities were observed.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfRADIATION ONCOLOGY JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleChemoradiotherapy in squamous cell carcinoma of the anal canal: a single institution experience-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorKyung Hwan Kim-
dc.contributor.googleauthorJee Suk Chang-
dc.contributor.googleauthorKi Chang Keum-
dc.contributor.googleauthorJoong Bae Ahn-
dc.contributor.googleauthorChang Geol Lee-
dc.contributor.googleauthorWoong Sub Koom-
dc.identifier.doi10.3857/roj.2013.31.1.25-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00272-
dc.contributor.localIdA00273-
dc.contributor.localIdA02262-
dc.contributor.localIdA03240-
dc.contributor.localIdA04658-
dc.relation.journalcodeJ02592-
dc.identifier.eissn2234-3164-
dc.identifier.pmid23620866-
dc.subject.keywordAnal canal-
dc.subject.keywordChemoradiotherapy-
dc.subject.keywordSquamous cell carcinoma-
dc.subject.keywordSurvival-
dc.contributor.alternativeNameKeum, Ki Chang-
dc.contributor.alternativeNameKoom, Woong Sub-
dc.contributor.alternativeNameAhn, Joong Bae-
dc.contributor.alternativeNameLee, Chang Geol-
dc.contributor.affiliatedAuthorKeum, Ki Chang-
dc.contributor.affiliatedAuthorKoom, Woong Sub-
dc.contributor.affiliatedAuthorAhn, Joong Bae-
dc.contributor.affiliatedAuthorLee, Chang Geol-
dc.rights.accessRightsfree-
dc.citation.volume31-
dc.citation.number1-
dc.citation.startPage25-
dc.citation.endPage33-
dc.identifier.bibliographicCitationRADIATION ONCOLOGY JOURNAL, Vol.31(1) : 25-33, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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