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Efficacy of intraoperative dexmedetomidine infusion on emergence agitation and quality of recovery after nasal surgery

DC Field Value Language
dc.contributor.author구본녀-
dc.contributor.author김소연-
dc.contributor.author김정민-
dc.contributor.author이재훈-
dc.date.accessioned2014-12-18T08:54:30Z-
dc.date.available2014-12-18T08:54:30Z-
dc.date.issued2013-
dc.identifier.issn0007-0912-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87173-
dc.description.abstractBackground Emergence agitation is common after nasal surgery. We investigated the effects of intraoperative dexmedetomidine infusion on emergence agitation and quality of recovery after nasal surgery in adult patients. Methods One hundred patients undergoing nasal surgery were randomized into two groups. The dexmedetomidine group (Group D, n=50) received dexmedetomidine infusion at a rate of 0.4 μg kg−1 h−1 from induction of anaesthesia until extubation, while the control group (Group C, n=50) received volume-matched normal saline infusion as placebo. Propofol (1.5–2 mg kg−1) and fentanyl (1 μg kg−1) were used for induction of anaesthesia, and desflurane was used for maintenance of anaesthesia. The incidence of agitation, haemodynamic parameters, and recovery characteristics were evaluated during emergence. A 40-item quality-of-recovery questionnaire (QoR-40) was provided to patients 24 h after surgery. Results The incidence of agitation was lower in Group D than Group C (28 vs 52%, P=0.014). Mean arterial pressure and heart rate were more stable in Group D than in Group C during emergence (P<0.05). Time to extubation, bispectral index, and respiratory rate at extubation were similar between the groups. Global QoR-40 score at 24 h after surgery was higher in Group D (median [range], 183 [146 –198]) compared with Group C (178 [133–196]) (P=0.041). Conclusions Intraoperative infusion of dexmedetomidine provided smooth and haemodynamically stable emergence. It also improved quality of recovery after nasal surgery.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfBRITISH JOURNAL OF ANAESTHESIA-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAnesthesia Recovery Period*-
dc.subject.MESHBlood Pressure/drug effects-
dc.subject.MESHDexmedetomidine/pharmacology*-
dc.subject.MESHDouble-Blind Method-
dc.subject.MESHFemale-
dc.subject.MESHHeart Rate/drug effects-
dc.subject.MESHHumans-
dc.subject.MESHHypnotics and Sedatives/pharmacology*-
dc.subject.MESHIncidence-
dc.subject.MESHIntraoperative Care/methods*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNasal Surgical Procedures*-
dc.subject.MESHPsychomotor Agitation/epidemiology*-
dc.subject.MESHSodium Chloride/administration & dosage-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHYoung Adult-
dc.titleEfficacy of intraoperative dexmedetomidine infusion on emergence agitation and quality of recovery after nasal surgery-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology (마취통증의학)-
dc.contributor.googleauthorS. Y. Kim-
dc.contributor.googleauthorJ. M. Kim-
dc.contributor.googleauthorJ. H. Lee-
dc.contributor.googleauthorB. M. Song-
dc.contributor.googleauthorB. N. Koo-
dc.identifier.doi10.1093/bja/aet056-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00193-
dc.contributor.localIdA00884-
dc.contributor.localIdA00616-
dc.contributor.localIdA03092-
dc.relation.journalcodeJ00405-
dc.identifier.eissn1471-6771-
dc.identifier.pmid23524149-
dc.identifier.urlhttp://bja.oxfordjournals.org/content/111/2/222.long-
dc.subject.keywordanaesthesia-
dc.subject.keywordgeneral-
dc.subject.keywordcomplications-
dc.subject.keywordextubation trachea-
dc.subject.keywordpharmacology-
dc.subject.keyworddexmedetomidine-
dc.subject.keywordrecovery-
dc.subject.keywordpostoperative-
dc.contributor.alternativeNameKu, Bon Nyo-
dc.contributor.alternativeNameKim, So Yeon-
dc.contributor.alternativeNameKim, Jeongmin-
dc.contributor.alternativeNameLee, Jae Hoon-
dc.contributor.affiliatedAuthorKu, Bon Nyo-
dc.contributor.affiliatedAuthorKim, Jeongmin-
dc.contributor.affiliatedAuthorKim, So Yeon-
dc.contributor.affiliatedAuthorLee, Jae Hoon-
dc.rights.accessRightsnot free-
dc.citation.volume111-
dc.citation.number2-
dc.citation.startPage222-
dc.citation.endPage228-
dc.identifier.bibliographicCitationBRITISH JOURNAL OF ANAESTHESIA, Vol.111(2) : 222-228, 2013-
dc.identifier.rimsid32536-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers

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