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Preconditioning effects of the anesthetic administered to the donor on grafted kidney function in living donor kidney transplantation recipients

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dc.contributor.author구본녀-
dc.contributor.author김소연-
dc.contributor.author김정민-
dc.contributor.author박진하-
dc.contributor.author이재훈-
dc.contributor.author주동진-
dc.date.accessioned2014-12-18T08:53:28Z-
dc.date.available2014-12-18T08:53:28Z-
dc.date.issued2013-
dc.identifier.issn0375-9393-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87140-
dc.description.abstractBACKGROUND: In living donor kidney transplantation (LDKT), we evaluated if there was any difference in grafted kidney function according to the type of anesthetic used in the donor because some laboratory studies have demonstrated that volatile anesthetics at clinically relevant concentrations protect the kidneys against renal ischemia-reperfusion injury. METHODS: In part I of the study, we retrospectively compared grafted kidney function [serum creatinine levels (Cr) and estimated glomerular filtration rates (eGFR) in recipients of LDKT] according to the type of donors' volatile anesthetic (sevoflurane [group Sevo, 166 patients], isoflurane [group Iso, 55] or desflurane [group Des, 61]). In part II, we prospectively compared grafted kidney function and neutrophil gelatinase-associated lipocalin (NGAL) levels in the serum and urine of recipients according to the anesthetic used in the donor (desflurane [group Des, N.=50] vs. propofol [group Pro, N.=50]). RESULTS: In part I, the eGFR of the Des group was greater than that of the Sevo or Iso groups (P=0.017) until POD 7. However, in part II, there were no significant changes in Cr and eGFR by POD 7, no differences in the levels of NGAL in the serum and urine on POD 1 and 2, or in Cr and eGFR on the day of discharge between the Des and Pro groups. CONCLUSIONS: The inhalational anesthetic administered to donors does not improve grafted kidney function in recipients undergoing LDKT to a greater extent than propofol.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfMINERVA ANESTESIOLOGICA-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAnesthetics/therapeutic use*-
dc.subject.MESHCreatinine/blood-
dc.subject.MESHElectrocardiography-
dc.subject.MESHFemale-
dc.subject.MESHGlomerular Filtration Rate/drug effects-
dc.subject.MESHGlomerular Filtration Rate/physiology-
dc.subject.MESHHumans-
dc.subject.MESHKidney/physiology*-
dc.subject.MESHKidney Transplantation/methods*-
dc.subject.MESHLipocalins/blood-
dc.subject.MESHLipocalins/urine-
dc.subject.MESHLiving Donors*-
dc.subject.MESHMale-
dc.subject.MESHProspective Studies-
dc.subject.MESHReperfusion Injury/prevention & control*-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTreatment Outcome-
dc.titlePreconditioning effects of the anesthetic administered to the donor on grafted kidney function in living donor kidney transplantation recipients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology (마취통증의학)-
dc.contributor.googleauthorLee JH-
dc.contributor.googleauthorJoo DJ-
dc.contributor.googleauthorKim JM-
dc.contributor.googleauthorPark JH-
dc.contributor.googleauthorKim YS-
dc.contributor.googleauthorKoo BN-
dc.identifier.doi23419340-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00193-
dc.contributor.localIdA00884-
dc.contributor.localIdA01704-
dc.contributor.localIdA03948-
dc.contributor.localIdA00616-
dc.contributor.localIdA03092-
dc.relation.journalcodeJ02235-
dc.identifier.eissn1827-1596-
dc.identifier.pmid23419340-
dc.identifier.urlhttp://www.minervamedica.it/en/journals/minerva-anestesiologica/article.php?cod=R02Y2013N05A0504-
dc.subject.keywordAnesthetics-
dc.subject.keywordgeneral - Kidney transplantation- Living donors - Ischemic preconditioning-
dc.contributor.alternativeNameKu, Bon Nyo-
dc.contributor.alternativeNameKim, So Yeon-
dc.contributor.alternativeNameKim, Jeongmin-
dc.contributor.alternativeNamePark, Jin Ha-
dc.contributor.alternativeNameLee, Jae Hoon-
dc.contributor.alternativeNameJoo, Dong Jin-
dc.contributor.affiliatedAuthorKu, Bon Nyo-
dc.contributor.affiliatedAuthorKim, Jeongmin-
dc.contributor.affiliatedAuthorPark, Jin Ha-
dc.contributor.affiliatedAuthorJoo, Dong Jin-
dc.contributor.affiliatedAuthorKim, So Yeon-
dc.contributor.affiliatedAuthorLee, Jae Hoon-
dc.rights.accessRightsnot free-
dc.citation.volume79-
dc.citation.number5-
dc.citation.startPage504-
dc.citation.endPage514-
dc.identifier.bibliographicCitationMINERVA ANESTESIOLOGICA, Vol.79(5) : 504-514, 2013-
dc.identifier.rimsid32516-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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