Cited 107 times in
Burn-wound healing effect of gelatin/polyurethane nanofiber scaffold containing silver-sulfadiazine.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 문성환 | - |
dc.date.accessioned | 2014-12-18T08:53:00Z | - |
dc.date.available | 2014-12-18T08:53:00Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1550-7033 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/87126 | - |
dc.description.abstract | Despite the fact that advances of burn treatment have led to reduction in the morbidity caused by burns, burn infection is still a serious problem. In this study, we designed blended synthetic and natural polymers nanofiber scaffolds using polyurethane (PU) and gelatin, which were prepared by an electrospinning method. Silver-sulfadiazine (SSD) was co-mixed to the blended polymer solution for being incorporated into the nanofibers after the electrospinning, followed by examination of burn-wound healing effect. The nanofiber scaffolds containing SSD should not only serve as a substrate for skin regeneration, but may also deliver suitable drugs, within a controlled manner during healing. The SSD release was able to prevent the growth of a wide array of bacteria and accelerate the wound healing by preventing infection. Therefore it could accelerate the burn-wound closure rate. We confirmed that PU/gelatin nanofiber scaffolds containing SSD lead to enhanced regeneration of burn-wounds. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JOURNAL OF BIOMEDICAL NANOTECHNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Burns/drug therapy* | - |
dc.subject.MESH | Burns/enzymology | - |
dc.subject.MESH | Burns/pathology | - |
dc.subject.MESH | Cattle | - |
dc.subject.MESH | Gelatin/chemistry* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Matrix Metalloproteinase 2/metabolism | - |
dc.subject.MESH | Matrix Metalloproteinase 9/metabolism | - |
dc.subject.MESH | Nanofibers/chemistry* | - |
dc.subject.MESH | Polyurethanes/chemistry* | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Silver Sulfadiazine/pharmacology | - |
dc.subject.MESH | Silver Sulfadiazine/therapeutic use* | - |
dc.subject.MESH | Tissue Scaffolds/chemistry* | - |
dc.subject.MESH | Wound Healing*/drug effects | - |
dc.title | Burn-wound healing effect of gelatin/polyurethane nanofiber scaffold containing silver-sulfadiazine. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Orthopedic Surgery (정형외과학) | - |
dc.contributor.googleauthor | Heo, Dong Nyoung | - |
dc.contributor.googleauthor | Yang, Dae Hyeok | - |
dc.contributor.googleauthor | Lee, Jung Bok | - |
dc.contributor.googleauthor | Bae, Min Soo | - |
dc.contributor.googleauthor | Kim, Jung Ho | - |
dc.contributor.googleauthor | Moon, Seong Hwan | - |
dc.contributor.googleauthor | Chun, Heoung Jae | - |
dc.contributor.googleauthor | Kim, Chun Ho | - |
dc.contributor.googleauthor | Lim, Ho-Nam | - |
dc.contributor.googleauthor | Kwon, Il Keun | - |
dc.identifier.doi | 10.1166/jbn.2013.1509 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01365 | - |
dc.relation.journalcode | J01268 | - |
dc.identifier.eissn | 1550-7041 | - |
dc.identifier.pmid | 23621008 | - |
dc.identifier.url | http://www.ingentaconnect.com/content/asp/jbn/2013/00000009/00000003/art00022 | - |
dc.subject.keyword | BURN WOUND HEALING | - |
dc.subject.keyword | ELECTROSPINNING | - |
dc.subject.keyword | PU/GELATIN NANOFIBER SCAFFOLD | - |
dc.subject.keyword | SILVER-SULFADIAZINE | - |
dc.contributor.alternativeName | Moon, Seong Hwan | - |
dc.contributor.affiliatedAuthor | Moon, Seong Hwan | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 9 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 511 | - |
dc.citation.endPage | 515 | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, Vol.9(3) : 511-515, 2013 | - |
dc.identifier.rimsid | 32507 | - |
dc.type.rims | ART | - |
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