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Burn-wound healing effect of gelatin/polyurethane nanofiber scaffold containing silver-sulfadiazine.

Authors
 Heo, Dong Nyoung  ;  Yang, Dae Hyeok  ;  Lee, Jung Bok  ;  Bae, Min Soo  ;  Kim, Jung Ho  ;  Moon, Seong Hwan  ;  Chun, Heoung Jae  ;  Kim, Chun Ho  ;  Lim, Ho-Nam  ;  Kwon, Il Keun 
Citation
 JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, Vol.9(3) : 511-515, 2013 
Journal Title
 JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 
ISSN
 1550-7033 
Issue Date
2013
MeSH
Animals ; Burns/drug therapy* ; Burns/enzymology ; Burns/pathology ; Cattle ; Gelatin/chemistry* ; Male ; Matrix Metalloproteinase 2/metabolism ; Matrix Metalloproteinase 9/metabolism ; Nanofibers/chemistry* ; Polyurethanes/chemistry* ; Rats ; Rats, Sprague-Dawley ; Silver Sulfadiazine/pharmacology ; Silver Sulfadiazine/therapeutic use* ; Tissue Scaffolds/chemistry* ; Wound Healing*/drug effects
Keywords
BURN WOUND HEALING ; ELECTROSPINNING ; PU/GELATIN NANOFIBER SCAFFOLD ; SILVER-SULFADIAZINE
Abstract
Despite the fact that advances of burn treatment have led to reduction in the morbidity caused by burns, burn infection is still a serious problem. In this study, we designed blended synthetic and natural polymers nanofiber scaffolds using polyurethane (PU) and gelatin, which were prepared by an electrospinning method. Silver-sulfadiazine (SSD) was co-mixed to the blended polymer solution for being incorporated into the nanofibers after the electrospinning, followed by examination of burn-wound healing effect. The nanofiber scaffolds containing SSD should not only serve as a substrate for skin regeneration, but may also deliver suitable drugs, within a controlled manner during healing. The SSD release was able to prevent the growth of a wide array of bacteria and accelerate the wound healing by preventing infection. Therefore it could accelerate the burn-wound closure rate. We confirmed that PU/gelatin nanofiber scaffolds containing SSD lead to enhanced regeneration of burn-wounds.
Full Text
http://www.ingentaconnect.com/content/asp/jbn/2013/00000009/00000003/art00022
DOI
10.1166/jbn.2013.1509
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
Yonsei Authors
Moon, Seong Hwan(문성환)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87126
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