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Cited 11 times in

Usefulness of Oxford Classification in Assessing Immunoglobulin A Nephropathy After Transplantation

DC FieldValueLanguage
dc.contributor.author김명수-
dc.contributor.author김순일-
dc.contributor.author김유선-
dc.contributor.author임범진-
dc.contributor.author정현주-
dc.contributor.author주동진-
dc.contributor.author허규하-
dc.date.accessioned2014-12-18T08:52:42Z-
dc.date.available2014-12-18T08:52:42Z-
dc.date.issued2013-
dc.identifier.issn0041-1337-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87117-
dc.description.abstractBACKGROUND: We explored the efficacy of the Oxford classification for assessing native immunoglobulin A nephropathy (IgAN) in posttransplantation patients compared with the glomerular injury score and Haas classification. METHODS: A total of 125 renal allograft biopsies obtained from 114 patients diagnosed with IgAN regardless of original disease were assessed. RESULTS: The average time to biopsy was 70.5±45.3 months after transplantation. Glomeruli showed normal histology in 18.4%. Mesangial hypercellularity (M1), endocapillary hypercellularity (E1), segmental glomerulosclerosis (S1), and tubulointerstitial fibrosis (T1-2) were present in 12.8%, 6.4%, 45.6%, and 20.8% of the samples, respectively. There was a significant correlation between Oxford-MEST scores and glomerular injury score or Haas subclass. S1 and T1-2 were correlated with elevated serum creatinine level, proteinuria, and decreased estimated glomerular filtration rate, and E1 was correlated with decreased estimated glomerular filtration rate at the time of biopsy. The 10- and 15-year graft survival rates were 62.9% and 34.3%, respectively. The graft survival rate was significantly lower in the presence of S1 and T1-2. Endocapillary hypercellularity, segmental sclerosis, and tubulointerstitial fibrosis predicted graft survival and endocapillary hypercellularity and tubulointerstitial fibrosis also predicted serum creatinine doubling. CONCLUSIONS: The Oxford classification scheme is useful for evaluating chronic graft dysfunction in patients with posttransplantation IgAN. In addition to tubulointerstitial fibrosis, the presence of endocapillary hypercellularity and segmental sclerosis should be included in the pathology report.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfTRANSPLANTATION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHBiopsy-
dc.subject.MESHCell Proliferation-
dc.subject.MESHFemale-
dc.subject.MESHFibrosis/pathology-
dc.subject.MESHGlomerular Filtration Rate-
dc.subject.MESHGlomerulonephritis, IGA/classification*-
dc.subject.MESHGlomerulonephritis, IGA/diagnosis*-
dc.subject.MESHGlomerulosclerosis, Focal Segmental/diagnosis-
dc.subject.MESHGraft Survival-
dc.subject.MESHHumans-
dc.subject.MESHKidney Glomerulus/pathology-
dc.subject.MESHKidney Transplantation/adverse effects*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPostoperative Complications-
dc.subject.MESHRenal Insufficiency/complications-
dc.subject.MESHRenal Insufficiency/surgery*-
dc.subject.MESHYoung Adult-
dc.titleUsefulness of Oxford Classification in Assessing Immunoglobulin A Nephropathy After Transplantation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorBeom Jin Lim-
dc.contributor.googleauthorDong Jin Joo-
dc.contributor.googleauthorMyoung Soo Kim-
dc.contributor.googleauthorYu Seun Kim-
dc.contributor.googleauthorSoon Il Kim-
dc.contributor.googleauthorYeonhee Kim-
dc.contributor.googleauthorKyu Ha Huh-
dc.contributor.googleauthorMyung Ju Koh-
dc.contributor.googleauthorHyeon Joo Jeong-
dc.identifier.doi10.1097/TP.0b013e318291de65-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00649-
dc.contributor.localIdA00785-
dc.contributor.localIdA03363-
dc.contributor.localIdA03771-
dc.contributor.localIdA03948-
dc.contributor.localIdA04344-
dc.contributor.localIdA00424-
dc.relation.journalcodeJ02754-
dc.identifier.eissn1534-6080-
dc.identifier.pmid23677050-
dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00007890-201306270-00011&LSLINK=80&D=ovft-
dc.subject.keywordIgA nephropathy-
dc.subject.keywordOxford classification-
dc.subject.keywordEndocapillary proliferation-
dc.subject.keywordSegmental glomerulosclerosis-
dc.subject.keywordTransplantation-
dc.contributor.alternativeNameKim, Myoung Soo-
dc.contributor.alternativeNameKim, Soon Il-
dc.contributor.alternativeNameKim, Yu Seun-
dc.contributor.alternativeNameLim, Beom Jin-
dc.contributor.alternativeNameJeong, Hyeon Joo-
dc.contributor.alternativeNameJoo, Dong Jin-
dc.contributor.alternativeNameHuh, Kyu Ha-
dc.contributor.affiliatedAuthorKim, Soon Il-
dc.contributor.affiliatedAuthorKim, Yu Seun-
dc.contributor.affiliatedAuthorLim, Beom Jin-
dc.contributor.affiliatedAuthorJeong, Hyeon Joo-
dc.contributor.affiliatedAuthorJoo, Dong Jin-
dc.contributor.affiliatedAuthorHuh, Kyu Ha-
dc.contributor.affiliatedAuthorKim, Myoung Soo-
dc.rights.accessRightsnot free-
dc.citation.volume95-
dc.citation.number12-
dc.citation.startPage1491-
dc.citation.endPage1497-
dc.identifier.bibliographicCitationTRANSPLANTATION, Vol.95(12) : 1491-1497, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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