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Mizoribine Versus Mycophenolate Mofetil in Combination Therapy With Tacrolimus for De Novo Kidney Transplantation: Evaluation of Efficacy and Safety

DC FieldValueLanguage
dc.contributor.author김유선-
dc.contributor.author주동진-
dc.contributor.author주만기-
dc.contributor.author허규하-
dc.date.accessioned2014-12-18T08:49:32Z-
dc.date.available2014-12-18T08:49:32Z-
dc.date.issued2013-
dc.identifier.issn0041-1345-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87021-
dc.description.abstractThe present study compared the efficacy and safety of mizoribine (MZR) with mycophenolate mofetil (MMF) in kidney transplantation. This multicenter, randomized clinical trial. Employed doses of study drug tailored to the immunosuppressive need. The primary efficacy outcome was the incidence of biopsy-proven acute rejection episodes (BPAR). The safety of the study drug was assessed using the incidences of adverse events, drug discontinuations, and abnormal laboratory results. The 7 (6.4%) BPARs above grade II were observed in the MZR group noninferior to the 2 (1.8%) in the MMF group (95% confidence interval, -0.007-0.097 > noninferiority limit [-0.2]). BPAR was significantly decreased in the MZR group after the dose change (17/41 [41.4%] vs 8/69 [11.6%]; P < .0001) and the incidence of BPAR was similar between the MZR and MMF groups after the dose change (P = .592). The uric acid level was significantly elevated in the MZR group (P = .002). In conclusion, the efficacy and safety of MZR were similar and statistically noninferior to MMF in combination therapy with tacrolimus.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfTRANSPLANTATION PROCEEDINGS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHDrug Therapy, Combination-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunosuppressive Agents/administration & dosage*-
dc.subject.MESHImmunosuppressive Agents/adverse effects-
dc.subject.MESHKidney Transplantation*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMycophenolic Acid/administration & dosage-
dc.subject.MESHMycophenolic Acid/adverse effects-
dc.subject.MESHMycophenolic Acid/analogs & derivatives*-
dc.subject.MESHRibonucleosides/administration & dosage*-
dc.subject.MESHRibonucleosides/adverse effects-
dc.subject.MESHTacrolimus/administration & dosage*-
dc.subject.MESHTacrolimus/adverse effects-
dc.subject.MESHYoung Adult-
dc.titleMizoribine Versus Mycophenolate Mofetil in Combination Therapy With Tacrolimus for De Novo Kidney Transplantation: Evaluation of Efficacy and Safety-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthorM.K. Ju-
dc.contributor.googleauthorK.H. Huh-
dc.contributor.googleauthorK.T. Park-
dc.contributor.googleauthorS.J. Kim-
dc.contributor.googleauthorB.H. Cho-
dc.contributor.googleauthorC.D. Kim-
dc.contributor.googleauthorB.J. So-
dc.contributor.googleauthorC.M. Kang-
dc.contributor.googleauthorS. Lee-
dc.contributor.googleauthorD.J. Joo-
dc.contributor.googleauthorY.S. Kim-
dc.identifier.doi10.1016/j.transproceed.2012.12.028-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00785-
dc.contributor.localIdA03948-
dc.contributor.localIdA03949-
dc.contributor.localIdA04344-
dc.relation.journalcodeJ02755-
dc.identifier.eissn1873-2623-
dc.identifier.pmid23726602-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0041134513000857-
dc.subject.keywordAdult-
dc.subject.keywordAged-
dc.subject.keywordDrug Therapy, Combination-
dc.subject.keywordFemale-
dc.subject.keywordHumans-
dc.subject.keywordImmunosuppressive Agents/administration & dosage*-
dc.subject.keywordImmunosuppressive Agents/adverse effects-
dc.subject.keywordKidney Transplantation*-
dc.subject.keywordMale-
dc.subject.keywordMiddle Aged-
dc.subject.keywordMycophenolic Acid/administration & dosage-
dc.subject.keywordMycophenolic Acid/adverse effects-
dc.subject.keywordMycophenolic Acid/analogs & derivatives*-
dc.subject.keywordRibonucleosides/administration & dosage*-
dc.subject.keywordRibonucleosides/adverse effects-
dc.subject.keywordTacrolimus/administration & dosage*-
dc.subject.keywordTacrolimus/adverse effects-
dc.subject.keywordYoung Adult-
dc.contributor.alternativeNameKim, Yu Seun-
dc.contributor.alternativeNameJoo, Dong Jin-
dc.contributor.alternativeNameJoo, Man Ki-
dc.contributor.alternativeNameHuh, Kyu Ha-
dc.contributor.affiliatedAuthorKim, Yu Seun-
dc.contributor.affiliatedAuthorJoo, Dong Jin-
dc.contributor.affiliatedAuthorJoo, Man Ki-
dc.contributor.affiliatedAuthorHuh, Kyu Ha-
dc.rights.accessRightsnot free-
dc.citation.volume45-
dc.citation.number4-
dc.citation.startPage1481-
dc.citation.endPage1486-
dc.identifier.bibliographicCitationTRANSPLANTATION PROCEEDINGS, Vol.45(4) : 1481-1486, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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