Cited 7 times in
Mizoribine Versus Mycophenolate Mofetil in Combination Therapy With Tacrolimus for De Novo Kidney Transplantation: Evaluation of Efficacy and Safety
DC Field | Value | Language |
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dc.contributor.author | 김유선 | - |
dc.contributor.author | 주동진 | - |
dc.contributor.author | 주만기 | - |
dc.contributor.author | 허규하 | - |
dc.date.accessioned | 2014-12-18T08:49:32Z | - |
dc.date.available | 2014-12-18T08:49:32Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0041-1345 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/87021 | - |
dc.description.abstract | The present study compared the efficacy and safety of mizoribine (MZR) with mycophenolate mofetil (MMF) in kidney transplantation. This multicenter, randomized clinical trial. Employed doses of study drug tailored to the immunosuppressive need. The primary efficacy outcome was the incidence of biopsy-proven acute rejection episodes (BPAR). The safety of the study drug was assessed using the incidences of adverse events, drug discontinuations, and abnormal laboratory results. The 7 (6.4%) BPARs above grade II were observed in the MZR group noninferior to the 2 (1.8%) in the MMF group (95% confidence interval, -0.007-0.097 > noninferiority limit [-0.2]). BPAR was significantly decreased in the MZR group after the dose change (17/41 [41.4%] vs 8/69 [11.6%]; P < .0001) and the incidence of BPAR was similar between the MZR and MMF groups after the dose change (P = .592). The uric acid level was significantly elevated in the MZR group (P = .002). In conclusion, the efficacy and safety of MZR were similar and statistically noninferior to MMF in combination therapy with tacrolimus. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | TRANSPLANTATION PROCEEDINGS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Drug Therapy, Combination | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunosuppressive Agents/administration & dosage* | - |
dc.subject.MESH | Immunosuppressive Agents/adverse effects | - |
dc.subject.MESH | Kidney Transplantation* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mycophenolic Acid/administration & dosage | - |
dc.subject.MESH | Mycophenolic Acid/adverse effects | - |
dc.subject.MESH | Mycophenolic Acid/analogs & derivatives* | - |
dc.subject.MESH | Ribonucleosides/administration & dosage* | - |
dc.subject.MESH | Ribonucleosides/adverse effects | - |
dc.subject.MESH | Tacrolimus/administration & dosage* | - |
dc.subject.MESH | Tacrolimus/adverse effects | - |
dc.subject.MESH | Young Adult | - |
dc.title | Mizoribine Versus Mycophenolate Mofetil in Combination Therapy With Tacrolimus for De Novo Kidney Transplantation: Evaluation of Efficacy and Safety | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | M.K. Ju | - |
dc.contributor.googleauthor | K.H. Huh | - |
dc.contributor.googleauthor | K.T. Park | - |
dc.contributor.googleauthor | S.J. Kim | - |
dc.contributor.googleauthor | B.H. Cho | - |
dc.contributor.googleauthor | C.D. Kim | - |
dc.contributor.googleauthor | B.J. So | - |
dc.contributor.googleauthor | C.M. Kang | - |
dc.contributor.googleauthor | S. Lee | - |
dc.contributor.googleauthor | D.J. Joo | - |
dc.contributor.googleauthor | Y.S. Kim | - |
dc.identifier.doi | 10.1016/j.transproceed.2012.12.028 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00785 | - |
dc.contributor.localId | A03948 | - |
dc.contributor.localId | A03949 | - |
dc.contributor.localId | A04344 | - |
dc.relation.journalcode | J02755 | - |
dc.identifier.eissn | 1873-2623 | - |
dc.identifier.pmid | 23726602 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0041134513000857 | - |
dc.subject.keyword | Adult | - |
dc.subject.keyword | Aged | - |
dc.subject.keyword | Drug Therapy, Combination | - |
dc.subject.keyword | Female | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Immunosuppressive Agents/administration & dosage* | - |
dc.subject.keyword | Immunosuppressive Agents/adverse effects | - |
dc.subject.keyword | Kidney Transplantation* | - |
dc.subject.keyword | Male | - |
dc.subject.keyword | Middle Aged | - |
dc.subject.keyword | Mycophenolic Acid/administration & dosage | - |
dc.subject.keyword | Mycophenolic Acid/adverse effects | - |
dc.subject.keyword | Mycophenolic Acid/analogs & derivatives* | - |
dc.subject.keyword | Ribonucleosides/administration & dosage* | - |
dc.subject.keyword | Ribonucleosides/adverse effects | - |
dc.subject.keyword | Tacrolimus/administration & dosage* | - |
dc.subject.keyword | Tacrolimus/adverse effects | - |
dc.subject.keyword | Young Adult | - |
dc.contributor.alternativeName | Kim, Yu Seun | - |
dc.contributor.alternativeName | Joo, Dong Jin | - |
dc.contributor.alternativeName | Joo, Man Ki | - |
dc.contributor.alternativeName | Huh, Kyu Ha | - |
dc.contributor.affiliatedAuthor | Kim, Yu Seun | - |
dc.contributor.affiliatedAuthor | Joo, Dong Jin | - |
dc.contributor.affiliatedAuthor | Joo, Man Ki | - |
dc.contributor.affiliatedAuthor | Huh, Kyu Ha | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 45 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1481 | - |
dc.citation.endPage | 1486 | - |
dc.identifier.bibliographicCitation | TRANSPLANTATION PROCEEDINGS, Vol.45(4) : 1481-1486, 2013 | - |
dc.identifier.rimsid | 32102 | - |
dc.type.rims | ART | - |
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