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Comparison of serum and urinary nephrin levels between normal pregnancies and severe preeclampsia

DC FieldValueLanguage
dc.contributor.author권자영-
dc.contributor.author손가현-
dc.contributor.author윤보현-
dc.date.accessioned2014-12-18T08:49:10Z-
dc.date.available2014-12-18T08:49:10Z-
dc.date.issued2013-
dc.identifier.issn0301-2115-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87010-
dc.description.abstractOBJECTIVE: To compare the levels of urinary excretion of nephrin in women experiencing either normotensive or severe preeclamptic pregnancies, and to examine the relationship between urinary nephrin levels and clinical parameters of preeclampsia. STUDY DESIGN: In a case control study we collected serum and urine specimens from women with normal pregnancy (n=30) and from women with severe preeclampsia (n=43). Serum nephrin levels and urinary nephrin concentrations were measured in all patients. RESULTS: Both serum and urine concentrations of nephrin were significantly higher in the severe preeclamptic group than in the normal pregnancy group. In addition, we identified a significant relationship between urinary nephrin levels and urine protein concentrations in the severe preeclamptic group. Urine nephrin concentrations were also correlated with serum creatinine levels and with diastolic blood pressure in the severe preeclamptic group. CONCLUSION: The positive correlations observed in this study suggest that urinary nephrin excretion might play an important role in the pathogenesis of proteinuria during preeclampsia and could be a good indicator of renal damage.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfEUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHBiomarkers/blood-
dc.subject.MESHBiomarkers/urine-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMembrane Proteins/blood*-
dc.subject.MESHMembrane Proteins/urine*-
dc.subject.MESHPre-Eclampsia/blood*-
dc.subject.MESHPre-Eclampsia/urine*-
dc.subject.MESHPregnancy-
dc.subject.MESHVascular Endothelial Growth Factor Receptor-1/blood-
dc.titleComparison of serum and urinary nephrin levels between normal pregnancies and severe preeclampsia-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Obstetrics & Gynecology (산부인과학)-
dc.contributor.googleauthorGa Hyun Son-
dc.contributor.googleauthorJa Young Kwon-
dc.contributor.googleauthorSanghoo Lee-
dc.contributor.googleauthorJimyeong Park-
dc.contributor.googleauthorYoung-Jin Kim-
dc.contributor.googleauthorBohyon Yun-
dc.contributor.googleauthorJung Hwa Park-
dc.identifier.doi10.1016/j.ejogrb.2012.10.011-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00246-
dc.contributor.localIdA01963-
dc.contributor.localIdA02555-
dc.relation.journalcodeJ00834-
dc.identifier.eissn1872-7654-
dc.identifier.pmid23116596-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0301211512004629-
dc.subject.keywordKidney-
dc.subject.keywordSevere preeclampsia-
dc.subject.keywordUrinary nephrin-
dc.contributor.alternativeNameKwon, Ja Young-
dc.contributor.alternativeNameSon, Ga Hyun-
dc.contributor.alternativeNameYun, Bo Hyon-
dc.contributor.affiliatedAuthorKwon, Ja Young-
dc.contributor.affiliatedAuthorSon, Ga Hyun-
dc.contributor.affiliatedAuthorYun, Bo Hyon-
dc.rights.accessRightsnot free-
dc.citation.volume166-
dc.citation.number2-
dc.citation.startPage139-
dc.citation.endPage144-
dc.identifier.bibliographicCitationEUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, Vol.166(2) : 139-144, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers

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