4 251

Cited 25 times in

Comparison of serum and urinary nephrin levels between normal pregnancies and severe preeclampsia

 Ga Hyun Son  ;  Ja Young Kwon  ;  Sanghoo Lee  ;  Jimyeong Park  ;  Young-Jin Kim  ;  Bohyon Yun  ;  Jung Hwa Park 
 European Journal of Obstetrics & Gynecology and Reproductive Biology, Vol.166(2) : 139-144, 2013 
Journal Title
 European Journal of Obstetrics & Gynecology and Reproductive Biology 
Issue Date
Adult ; Biomarkers/blood ; Biomarkers/urine ; Case-Control Studies ; Female ; Humans ; Membrane Proteins/blood* ; Membrane Proteins/urine* ; Pre-Eclampsia/blood* ; Pre-Eclampsia/urine* ; Pregnancy ; Vascular Endothelial Growth Factor Receptor-1/blood
Kidney ; Severe preeclampsia ; Urinary nephrin
OBJECTIVE: To compare the levels of urinary excretion of nephrin in women experiencing either normotensive or severe preeclamptic pregnancies, and to examine the relationship between urinary nephrin levels and clinical parameters of preeclampsia. STUDY DESIGN: In a case control study we collected serum and urine specimens from women with normal pregnancy (n=30) and from women with severe preeclampsia (n=43). Serum nephrin levels and urinary nephrin concentrations were measured in all patients. RESULTS: Both serum and urine concentrations of nephrin were significantly higher in the severe preeclamptic group than in the normal pregnancy group. In addition, we identified a significant relationship between urinary nephrin levels and urine protein concentrations in the severe preeclamptic group. Urine nephrin concentrations were also correlated with serum creatinine levels and with diastolic blood pressure in the severe preeclamptic group. CONCLUSION: The positive correlations observed in this study suggest that urinary nephrin excretion might play an important role in the pathogenesis of proteinuria during preeclampsia and could be a good indicator of renal damage.
Full Text
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Ja Young(권자영) ORCID logo https://orcid.org/0000-0003-3009-6325
Son, Ga Hyun(손가현)
Yun, Bo Hyon(윤보현) ORCID logo https://orcid.org/0000-0001-5703-797X
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.