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Comparison of serum and urinary nephrin levels between normal pregnancies and severe preeclampsia

Authors
 Ga Hyun Son ; Ja Young Kwon ; Jung Hwa Park ; Bohyon Yun ; Young-Jin Kim ; Jimyeong Park ; Sanghoo Lee 
Citation
 European Journal of Obstetrics & Gynecology and Reproductive Biology, Vol.166(2) : 139~144, 2013 
Journal Title
 European Journal of Obstetrics & Gynecology and Reproductive Biology 
ISSN
 0301-2115 
Issue Date
2013
Abstract
OBJECTIVE: To compare the levels of urinary excretion of nephrin in women experiencing either normotensive or severe preeclamptic pregnancies, and to examine the relationship between urinary nephrin levels and clinical parameters of preeclampsia. STUDY DESIGN: In a case control study we collected serum and urine specimens from women with normal pregnancy (n=30) and from women with severe preeclampsia (n=43). Serum nephrin levels and urinary nephrin concentrations were measured in all patients. RESULTS: Both serum and urine concentrations of nephrin were significantly higher in the severe preeclamptic group than in the normal pregnancy group. In addition, we identified a significant relationship between urinary nephrin levels and urine protein concentrations in the severe preeclamptic group. Urine nephrin concentrations were also correlated with serum creatinine levels and with diastolic blood pressure in the severe preeclamptic group. CONCLUSION: The positive correlations observed in this study suggest that urinary nephrin excretion might play an important role in the pathogenesis of proteinuria during preeclampsia and could be a good indicator of renal damage.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/87010
DOI
10.1016/j.ejogrb.2012.10.011
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Obstetrics & Gynecology
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0301211512004629
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