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Partial Virological Response to Adefovir Add-On Lamivudine Rescue Therapy in Patients with Lamivudine-Resistant Chronic Hepatitis B

DC FieldValueLanguage
dc.contributor.author김도영-
dc.contributor.author김승업-
dc.contributor.author박준용-
dc.contributor.author안상훈-
dc.contributor.author전영은-
dc.contributor.author전재윤-
dc.contributor.author최아라-
dc.contributor.author한광협-
dc.date.accessioned2014-12-18T08:48:49Z-
dc.date.available2014-12-18T08:48:49Z-
dc.date.issued2013-
dc.identifier.issn0012-2823-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87000-
dc.description.abstractBACKGROUND/AIMS: In patients with lamivudine (LAM)-resistant chronic hepatitis B (CHB) receiving adefovir (ADV) add-on LAM therapy, insufficient viral suppression or the appearance of additional ADV resistance has remained unresolved. This study determined the partial virological response (PVR) criteria to predict a virological response (VR) at week 96 in these patients. METHODS: 96 patients with LAM-resistant CHB (ADV add-on LAM therapy >2 years) were analyzed. For predicting VR at week 96, the area under the receiver operating characteristic curve values at different time points were compared to establish the optimal time point, and the maximal Youden index was calculated to determine the optimal cut-off hepatitis B virus (HBV) DNA level. RESULTS: 50 (52.1%) patients achieved VR at 2 years after ADV add-on LAM therapy. The optimal PVR criteria were determined to be HBV DNA 500 IU/ml at week 48. 44 (45.8%) patients who met optimal PVR criteria showed a significantly higher risk for detectable HBV DNA levels at week 96 than those with a favorable VR (HBV DNA <500 IU/ml) at week 48. CONCLUSIONS: This study suggested optimal PVR criteria in patients with LAM-resistant CHB receiving ADV add-on LAM therapy. Modification of the antiviral agent regimen should be considered if the serum HBV DNA level exceeds 500 IU/ml at week 48.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfDIGESTION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenine/administration & dosage-
dc.subject.MESHAdenine/analogs & derivatives*-
dc.subject.MESHAdult-
dc.subject.MESHArea Under Curve-
dc.subject.MESHDNA, Viral/blood*-
dc.subject.MESHDrug Resistance, Viral*-
dc.subject.MESHDrug Therapy, Combination-
dc.subject.MESHFemale-
dc.subject.MESHHepatitis B, Chronic/blood-
dc.subject.MESHHepatitis B, Chronic/drug therapy*-
dc.subject.MESHHepatitis B, Chronic/virology-
dc.subject.MESHHumans-
dc.subject.MESHLamivudine/administration & dosage*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOrganophosphonates/administration & dosage*-
dc.subject.MESHROC Curve-
dc.subject.MESHReverse Transcriptase Inhibitors/administration & dosage*-
dc.subject.MESHTreatment Outcome-
dc.titlePartial Virological Response to Adefovir Add-On Lamivudine Rescue Therapy in Patients with Lamivudine-Resistant Chronic Hepatitis B-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Obstetrics & Gynecology (산부인과학)-
dc.contributor.googleauthorChon Y.E.-
dc.contributor.googleauthorPark J.Y.-
dc.contributor.googleauthorAhn S.H.-
dc.contributor.googleauthorKim D.Y.-
dc.contributor.googleauthorHan K.-H.-
dc.contributor.googleauthorChon C.Y.-
dc.contributor.googleauthorChoi A.-
dc.contributor.googleauthorKim S.U-
dc.identifier.doi10.1159/000348853-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00654-
dc.contributor.localIdA01675-
dc.contributor.localIdA02226-
dc.contributor.localIdA03533-
dc.contributor.localIdA04104-
dc.contributor.localIdA04268-
dc.contributor.localIdA03544-
dc.contributor.localIdA00385-
dc.relation.journalcodeJ00734-
dc.identifier.eissn1421-9867-
dc.identifier.pmid23689059-
dc.identifier.urlhttp://www.karger.com/Article/FullText/348853-
dc.subject.keywordAdd-on therapy-
dc.subject.keywordAdefovir-
dc.subject.keywordChronic hepatitis B-
dc.subject.keywordHepatitis B virus DNA-
dc.subject.keywordHepatitis B virus-
dc.subject.keywordLamivudine-
dc.subject.keywordNucleos(t)ide analogue-
dc.subject.keywordPartial virological response-
dc.subject.keywordVirological response-
dc.contributor.alternativeNameKim, Do Young-
dc.contributor.alternativeNameKim, Seung Up-
dc.contributor.alternativeNamePark, Jun Yong-
dc.contributor.alternativeNameAhn, Sang Hoon-
dc.contributor.alternativeNameJeon, Young Eun-
dc.contributor.alternativeNameChon, Chae Yoon-
dc.contributor.alternativeNameChoi, A Ra-
dc.contributor.alternativeNameHan, Kwang Hyup-
dc.contributor.affiliatedAuthorKim, Seung Up-
dc.contributor.affiliatedAuthorPark, Jun Yong-
dc.contributor.affiliatedAuthorAhn, Sang Hoon-
dc.contributor.affiliatedAuthorJeon, Young Eun-
dc.contributor.affiliatedAuthorChoi, A Ra-
dc.contributor.affiliatedAuthorHan, Kwang Hyup-
dc.contributor.affiliatedAuthorChon, Chae Yoon-
dc.contributor.affiliatedAuthorKim, Do Young-
dc.rights.accessRightsnot free-
dc.citation.volume87-
dc.citation.number3-
dc.citation.startPage196-
dc.citation.endPage203-
dc.identifier.bibliographicCitationDIGESTION, Vol.87(3) : 196-203, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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