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Three-dimensional shear-wave elastography for differentiating benign and malignant breast lesions: comparison with two-dimensional shear-wave elastography

 Ji Hyun Youk  ;  Hye Mi Gweon  ;  Eun Ju Son  ;  Jin Chung  ;  Jeong-Ah Kim  ;  Eun-kyung Kim 
 EUROPEAN RADIOLOGY, Vol.23(6) : 1519-1527, 2013 
Journal Title
Issue Date
Adult ; Aged ; Area Under Curve ; Biopsy ; Breast/pathology* ; Breast Neoplasms/diagnosis* ; Breast Neoplasms/pathology* ; Diagnosis, Differential ; Elasticity Imaging Techniques/methods* ; Female ; Humans ; Image Processing, Computer-Assisted ; Imaging, Three-Dimensional ; Middle Aged ; Observer Variation ; ROC Curve ; Reproducibility of Results ; Retrospective Studies ; Stress, Mechanical ; Ultrasonography, Mammary/methods* ; Young Adult
Breast ; Ultrasound ; Elastography ; Shear wave ; Three-dimensional
OBJECTIVES: To evaluate the interobserver agreement and the diagnostic performance of 3D shear-wave elastography (SWE) for breast lesions in comparison with 2D SWE. METHODS: A total of 163 breast lesions (malignant 48, benign 115) in 146 women who underwent B-mode ultrasound and SWE before biopsy were included. Two radiologists reviewed six data sets (B-mode, SWE, and a combination of both for 2D and 3D ultrasound). B-mode and SWE features were recorded. BI-RADS category was assigned for B-mode and combined sets. Interobserver variability was assessed using the κ statistic. Diagnostic performance of each data set was evaluated using the area under the ROC curve (AUC). RESULTS: SWE showed substantial to almost perfect agreement, with Ehomo in 2D SWE being higher than in 3D SWE. The AUC of 2D SWE was higher than 3D SWE for all SWE features, significantly so for Ecol (0.933 vs. 0.867, P = 0.002) and Emax (0.961 vs. 0.874, P = 0.006). After adding SWE to B-mode ultrasound, the AUC in 2D ultrasound increased significantly (0.968 vs. 0.912, P = 0.008), but 3D ultrasound showed no significant difference (0.966 vs. 0.935; P = 0.07). CONCLUSION: For 3D SWE, interobserver agreement was good, but the diagnostic performance was inferior to 2D SWE even after adding to B-mode ultrasound. KEY POINTS : • Shear-wave elastography (SWE) provides further diagnostic information during breast ultrasound. • 3D SWE diagnostic performance is inferior to 2D SWE. • In 3D SWE, interobserver agreement was good. • 2D B-mode ultrasound showed significant diagnostic improvement when combined with 2D SWE. • 3D B-mode ultrasound performance was not significantly improved when combined with 3D SWE.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Gweon, Hye Mi(권혜미) ORCID logo https://orcid.org/0000-0002-3054-1532
Kim, Eun-Kyung(김은경) ORCID logo https://orcid.org/0000-0002-3368-5013
Kim, Jeong Ah(김정아) ORCID logo https://orcid.org/0000-0003-4949-4913
Son, Eun Ju(손은주) ORCID logo https://orcid.org/0000-0002-7895-0335
Youk, Ji Hyun(육지현) ORCID logo https://orcid.org/0000-0002-7787-780X
Chung, Jin(정진)
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