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Undifferentiated early gastric cancer diagnosed as differentiated histology based on forceps biopsy

DC FieldValueLanguage
dc.contributor.author김지현-
dc.contributor.author박효진-
dc.contributor.author윤선옥-
dc.contributor.author윤영훈-
dc.contributor.author이광원-
dc.contributor.author이용찬-
dc.contributor.author이정호-
dc.date.accessioned2014-12-18T08:47:31Z-
dc.date.available2014-12-18T08:47:31Z-
dc.date.issued2013-
dc.identifier.issn0344-0338-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/86960-
dc.description.abstractHistological diagnosis before endoscopic resection (ER) is important to determine whether ER should be performed; indeed, the use of ER for undifferentiated early gastric cancer (UD-EGC) remains controversial. The aim was to investigate the clinicopathological features of UD-EGC in ER specimens, diagnosed as differentiated histology based on biopsy. 289 patients with EGC were treated by ER. Among them, 13.1% were diagnosed as UD-EGC after ER, and 18.4% of them showed differentiated histology based on biopsy before ER. We analyzed UD-EGC with differentiated histology (D-group) compared to undifferentiated histology (UD-group) on biopsy. The D-group showed moderately differentiated adenocarcinoma on biopsy and poorly differentiated adenocarcinoma in ER specimens. The D-group was significantly associated with older age, intestinal metaplasia in the surrounding mucosa, and larger size than the UD-group. Gland portion of tumor, mixed-type Lauren classification, submucosal invasion, lymphovascular invasion, and perineural invasion were more common in the D-group than in the UD-group. The number of biopsies was not different between the groups. When comparing the histopathological mapping findings and endoscopic appearances of the D-group, the zone of transition from differentiated to undifferentiated histology was frequently found on one or two peripheral sides of the lesion. In conclusion, areas of EGC greater than 20mm with moderately differentiated histology on biopsy may contain an undifferentiated component. UD-EGC with differentiated histology on biopsy may show more aggressive behavior than UD-EGC, consistent with the biopsy pathology. Biopsy at several peripheral sides of the lesion may be helpful for diagnosis of UD histology before treatment.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfPathology Research and Practice-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleUndifferentiated early gastric cancer diagnosed as differentiated histology based on forceps biopsy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorJung Ho Lee-
dc.contributor.googleauthorJie-Hyun Kim-
dc.contributor.googleauthorKwangwon Rhee-
dc.contributor.googleauthorCheal Wung Huh-
dc.contributor.googleauthorYong Chan Lee-
dc.contributor.googleauthorSun Och Yoon-
dc.contributor.googleauthorYoung Hoon Youn-
dc.contributor.googleauthorHyojin Park-
dc.contributor.googleauthorSang In Lee-
dc.identifier.doi10.1016/j.prp.2013.02.014-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01774-
dc.contributor.localIdA02566-
dc.contributor.localIdA02583-
dc.contributor.localIdA02671-
dc.contributor.localIdA02988-
dc.contributor.localIdA03128-
dc.contributor.localIdA00996-
dc.relation.journalcodeJ02474-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0344033813000575-
dc.contributor.alternativeNameKim, Ji Hyun-
dc.contributor.alternativeNamePark, Hyo Jin-
dc.contributor.alternativeNameYoon, Sun Och-
dc.contributor.alternativeNameYoun, Young Hoon-
dc.contributor.alternativeNameRhee, Kwang Won-
dc.contributor.alternativeNameLee, Yong Chan-
dc.contributor.alternativeNameLee, Jung Ho-
dc.contributor.affiliatedAuthorPark, Hyo Jin-
dc.contributor.affiliatedAuthorYoon, Sun Och-
dc.contributor.affiliatedAuthorYoun, Young Hoon-
dc.contributor.affiliatedAuthorRhee, Kwang Won-
dc.contributor.affiliatedAuthorLee, Yong Chan-
dc.contributor.affiliatedAuthorLee, Jung Ho-
dc.contributor.affiliatedAuthorKim, Ji Hyun-
dc.rights.accessRightsnot free-
dc.citation.volume209-
dc.citation.number5-
dc.citation.startPage314-
dc.citation.endPage318-
dc.identifier.bibliographicCitationPathology Research and Practice, Vol.209(5) : 314-318, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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