Cited 50 times in
Metabolic phenotypes in triple-negative breast cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 구자승 | - |
dc.contributor.author | 정우희 | - |
dc.date.accessioned | 2014-12-18T08:47:28Z | - |
dc.date.available | 2014-12-18T08:47:28Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1010-4283 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/86958 | - |
dc.description.abstract | The aim of study was to investigate the metabolism of tumor and stromal cells necessary to determine differential tumor–stroma metabolic interactions according to the molecular subtypes of triple-negative breast cancer (TNBC). Tissues from 132 patients of TNBC were prepared for use as tissue microarrays (TMA). Expression of CK5/6, EGFR, claudin 3, claudin 4, claudin7, E-cadherin, AR, GGT1, STAT1, and interleukin-8 was evaluated by immunohistochemical staining using TMA to classify molecular subtypes of TNBC. In addition, immunohistochemical staining for Glut1, CAIX, BNIP3, MCT4, Beclin-1, LC3A, LC3B, and p62 was performed. According to glycolytic status determined by the immunohistochemical expression of Glut-1 and CAIX in tumor and stroma, the metabolic phenotypes of the TNBCs were defined as follows: Warburg type (tumor: glycolysis, stroma: non-glycolysis), reverse Warburg type (tumor: non-glycolysis, stroma: glycolysis), mixed metabolic type (tumor: glycolysis, stroma: glycolysis), and metabolic null type (tumor: non-glycolysis, stroma: non-glycolysis). TNBCs were classified as follows: 79 Warburg type (59.8 %), 7 reverse Warburg type (5.3 %), 24 mixed metabolic type (18.2 %), and 22 metabolic null type (16.7 %). There was no statistical significance between the metabolic phenotypes and molecular subtypes (P = 0.706). Reverse Warburg type showed the most dysfunctional mitochondrial status for stromal cells, while Warburg type showed the most functional mitochondrial status (P = 0.036). Regarding stromal autophagy status, reverse Warburg type showed the most activated status, while all of the Warburg and metabolic null types showed a non-activated status (P < 0.001). In conclusion, Warburg type was the most common metabolic phenotype in TNBC, while reverse Warburg type was the most unusual. Metabolic phenotypes did not differ among the molecular subtypes of TNBCs. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | TUMOR BIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Autophagy | - |
dc.subject.MESH | Biomarkers, Tumor/metabolism* | - |
dc.subject.MESH | Breast Neoplasms/classification* | - |
dc.subject.MESH | Breast Neoplasms/metabolism | - |
dc.subject.MESH | Breast Neoplasms/mortality | - |
dc.subject.MESH | Breast Neoplasms/pathology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fibroblasts/metabolism* | - |
dc.subject.MESH | Fibroblasts/pathology | - |
dc.subject.MESH | Glycolysis* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunoenzyme Techniques | - |
dc.subject.MESH | Lymphatic Metastasis | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mitochondria/metabolism* | - |
dc.subject.MESH | Mitochondria/pathology | - |
dc.subject.MESH | Neoplasm Grading | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Phenotype | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Receptor, ErbB-2/metabolism | - |
dc.subject.MESH | Receptors, Estrogen/metabolism | - |
dc.subject.MESH | Receptors, Progesterone/metabolism | - |
dc.subject.MESH | Stromal Cells/metabolism* | - |
dc.subject.MESH | Stromal Cells/pathology | - |
dc.subject.MESH | Survival Rate | - |
dc.subject.MESH | Tissue Array Analysis | - |
dc.title | Metabolic phenotypes in triple-negative breast cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Sewha Kim | - |
dc.contributor.googleauthor | Do Hee Kim | - |
dc.contributor.googleauthor | Woo-Hee Jung | - |
dc.contributor.googleauthor | Ja Seung Koo | - |
dc.identifier.doi | 10.1007/s13277-013-0707-1 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00198 | - |
dc.contributor.localId | A03671 | - |
dc.relation.journalcode | J02763 | - |
dc.identifier.eissn | 1423-0380 | - |
dc.identifier.pmid | 23443971 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs13277-013-0707-1 | - |
dc.subject.keyword | Breast cancer | - |
dc.subject.keyword | Reverse Warburg effect | - |
dc.subject.keyword | Triple negative | - |
dc.subject.keyword | Warburg effect | - |
dc.contributor.alternativeName | Koo, Ja Seung | - |
dc.contributor.alternativeName | Jung, Woo Hee | - |
dc.contributor.affiliatedAuthor | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | Jung, Woo Hee | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 34 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 1699 | - |
dc.citation.endPage | 1712 | - |
dc.identifier.bibliographicCitation | TUMOR BIOLOGY, Vol.34(3) : 1699-1712, 2013 | - |
dc.identifier.rimsid | 32059 | - |
dc.type.rims | ART | - |
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