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Effects of ulinastatin on coagulation in high-risk patients undergoing off-pump coronary artery bypass graft surgery

DC FieldValueLanguage
dc.contributor.author김나영-
dc.contributor.author방서욱-
dc.contributor.author송종욱-
dc.contributor.author심재광-
dc.date.accessioned2014-12-18T08:47:15Z-
dc.date.available2014-12-18T08:47:15Z-
dc.date.issued2013-
dc.identifier.issn2005-6419-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/86951-
dc.description.abstractBACKGROUND: Both systemic inflammatory reaction and regional myocardial ischemia/reperfusion injury may elicit hypercoagulability after off-pump coronary artery bypass grafting (OPCAB). We investigated the influence of ulinastatin, which suppresses the activity of polymorphonuclear leukocyte elastase and production of pro-inflammatory cytokines, on coagulation in patients with elevated high-sensitivity C-reactive protein (hsCRP) undergoing OPCAB. METHODS: Fifty patients whose preoperative hsCRP > 3.0 mg/L were randomly allocated into the ulinastatin (600,000 U) or control group. Serum concentrations of thrombin-antithrombin complex (TAT) and prothrombin fragment 1+2 (F1+2) were measured preoperatively, immediately after surgery, and at 24 h after surgery, respectively. Secondary endpoints included platelet factor (PF)-4, amount of blood loss, and transfusion requirement. RESULTS: All baseline values of TAT, F1+2, and PF-4 were higher than the normal range in both groups. F1+2 was elevated in both groups at immediate, and at 24 h after surgery as compared to baseline value, without any significant intergroup differences. Remaining coagulation parameters, transfusion requirement and blood loss during operation and postoperative 24 h were not different between the two groups. CONCLUSIONS: Intraoperative administration of ulinastatin did not convey beneficial influence in terms of coagulation and blood loss in high-risk patients with elevated hsCRP undergoing multivessel OPCAB, who already exhibited hypercoagulability before surgery.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfKOREAN JOURNAL OF ANESTHESIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleEffects of ulinastatin on coagulation in high-risk patients undergoing off-pump coronary artery bypass graft surgery-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology (마취통증의학)-
dc.contributor.googleauthorNa-Young Kim-
dc.contributor.googleauthorJae-Kwang Shim-
dc.contributor.googleauthorSeo-Ouk Bang-
dc.contributor.googleauthorJee-Suk Sim-
dc.contributor.googleauthorJong-Wook Song-
dc.contributor.googleauthorYoung-Lan Kwak-
dc.identifier.doi10.4097/kjae.2013.64.2.105-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01785-
dc.contributor.localIdA02060-
dc.contributor.localIdA02205-
dc.contributor.localIdA00348-
dc.relation.journalcodeJ01963-
dc.identifier.eissn2005-7563-
dc.identifier.pmid23459312-
dc.subject.keywordCoagulability-
dc.subject.keywordOPCAB-
dc.subject.keywordUlinastatin-
dc.subject.keywordhsCRP-
dc.contributor.alternativeNameKim, Na Young-
dc.contributor.alternativeNameBang, Sou Ouk-
dc.contributor.alternativeNameSong, Jong Wook-
dc.contributor.alternativeNameShim, Jae Kwang-
dc.contributor.affiliatedAuthorBang, Sou Ouk-
dc.contributor.affiliatedAuthorSong, Jong Wook-
dc.contributor.affiliatedAuthorShim, Jae Kwang-
dc.contributor.affiliatedAuthorKim, Na Young-
dc.rights.accessRightsfree-
dc.citation.volume64-
dc.citation.number2-
dc.citation.startPage105-
dc.citation.endPage111-
dc.identifier.bibliographicCitationKOREAN JOURNAL OF ANESTHESIOLOGY, Vol.64(2) : 105-111, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers

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