Cited 3 times in
A Randomized, Double Blinded, Clinical Trial to Assess the Efficacy and Cost Effectiveness of Omeprazole Compared to Rabeprazole in the Maintenance Therapy of Patients With Gastroesophageal Reflux Disease
DC Field | Value | Language |
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dc.contributor.author | 박효진 | - |
dc.date.accessioned | 2014-12-18T08:44:26Z | - |
dc.date.available | 2014-12-18T08:44:26Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 2093-0879 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/86865 | - |
dc.description.abstract | Background/Aims The aim of this study was to evaluate the efficacy and cost efficiency of omeprazole 10 mg and rabeprazole 10 mg once daily for 24 weeks in the maintenance therapy. Methods This was a randomized, open-label study enrolling 279 patients with erosive esophagitis A or B (Los Angeles classification) and typical gastroesophageal reflux disease symptoms. Patients who showed complete endoscopic and symptomatic healing after 8 weeks of proton pump inhibitor treatment were randomly allocated to maintenance treatment with omeprazole 10 mg once daily or rabeprazole 10 mg once daily for 42 weeks. The primary efficacy endpoint was the proportion of patients with symptomatic remission at 42 weeks. Results At the end of 42 weeks of maintenance therapy, 96.4% of omeprazole and 95.1% of rabeprazole treated patients remained symptom free ( > 0.05). Two drugs were also comparable with regard to the severity and frequency of reflux symptoms during the maintenance phase ( > 0.05). By the cost-minimization analysis, the mean total costs per patient for remaining symptom-free for 6 months were 241,775 won for omeprazole and 287,115 won for rabeprazole, respectively. Conclusions Omeprazole 10 mg appeared to have similar efficacy in maintaining symptomatic remission as rabeprazole 10 mg, but was superior to rabeprazole 10 mg in terms of cost efficiency in the maintenance therapy of gastroesophageal reflux disease symptoms. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | A Randomized, Double Blinded, Clinical Trial to Assess the Efficacy and Cost Effectiveness of Omeprazole Compared to Rabeprazole in the Maintenance Therapy of Patients With Gastroesophageal Reflux Disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Jung Ho Park | - |
dc.contributor.googleauthor | Hyojin Park | - |
dc.contributor.googleauthor | Dong Ho Lee | - |
dc.contributor.googleauthor | In Kyung Sung | - |
dc.identifier.doi | 10.5056/jnm.2013.19.2.219 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01774 | - |
dc.relation.journalcode | J01623 | - |
dc.identifier.eissn | 2093-0887 | - |
dc.identifier.pmid | 23667753 | - |
dc.subject.keyword | Cost-benefit analysis | - |
dc.subject.keyword | Gastroesophageal reflux | - |
dc.subject.keyword | Maintenance | - |
dc.contributor.alternativeName | Park, Hyo Jin | - |
dc.contributor.affiliatedAuthor | Park, Hyo Jin | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 19 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 219 | - |
dc.citation.endPage | 226 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY, Vol.19(2) : 219-226, 2013 | - |
dc.identifier.rimsid | 32034 | - |
dc.type.rims | ART | - |
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