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A Randomized, Double Blinded, Clinical Trial to Assess the Efficacy and Cost Effectiveness of Omeprazole Compared to Rabeprazole in the Maintenance Therapy of Patients With Gastroesophageal Reflux Disease

DC FieldValueLanguage
dc.contributor.author박효진-
dc.date.accessioned2014-12-18T08:44:26Z-
dc.date.available2014-12-18T08:44:26Z-
dc.date.issued2013-
dc.identifier.issn2093-0879-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/86865-
dc.description.abstractBackground/Aims The aim of this study was to evaluate the efficacy and cost efficiency of omeprazole 10 mg and rabeprazole 10 mg once daily for 24 weeks in the maintenance therapy. Methods This was a randomized, open-label study enrolling 279 patients with erosive esophagitis A or B (Los Angeles classification) and typical gastroesophageal reflux disease symptoms. Patients who showed complete endoscopic and symptomatic healing after 8 weeks of proton pump inhibitor treatment were randomly allocated to maintenance treatment with omeprazole 10 mg once daily or rabeprazole 10 mg once daily for 42 weeks. The primary efficacy endpoint was the proportion of patients with symptomatic remission at 42 weeks. Results At the end of 42 weeks of maintenance therapy, 96.4% of omeprazole and 95.1% of rabeprazole treated patients remained symptom free ( > 0.05). Two drugs were also comparable with regard to the severity and frequency of reflux symptoms during the maintenance phase ( > 0.05). By the cost-minimization analysis, the mean total costs per patient for remaining symptom-free for 6 months were 241,775 won for omeprazole and 287,115 won for rabeprazole, respectively. Conclusions Omeprazole 10 mg appeared to have similar efficacy in maintaining symptomatic remission as rabeprazole 10 mg, but was superior to rabeprazole 10 mg in terms of cost efficiency in the maintenance therapy of gastroesophageal reflux disease symptoms.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfJournal of Neurogastroenterology and Motility-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleA Randomized, Double Blinded, Clinical Trial to Assess the Efficacy and Cost Effectiveness of Omeprazole Compared to Rabeprazole in the Maintenance Therapy of Patients With Gastroesophageal Reflux Disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorJung Ho Park-
dc.contributor.googleauthorHyojin Park-
dc.contributor.googleauthorDong Ho Lee-
dc.contributor.googleauthorIn Kyung Sung-
dc.identifier.doi10.5056/jnm.2013.19.2.219-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01774-
dc.relation.journalcodeJ01623-
dc.contributor.alternativeNamePark, Hyo Jin-
dc.contributor.affiliatedAuthorPark, Hyo Jin-
dc.rights.accessRightsfree-
dc.citation.volume19-
dc.citation.number2-
dc.citation.startPage219-
dc.citation.endPage226-
dc.identifier.bibliographicCitationJournal of Neurogastroenterology and Motility, Vol.19(2) : 219-226, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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