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Estimating the Adjuvant Chemotherapy Effect in Elderly Stage II and III Colon Cancer Patients in an Observational Study

DC FieldValueLanguage
dc.contributor.author김남규-
dc.contributor.author노재경-
dc.contributor.author라선영-
dc.contributor.author신상준-
dc.contributor.author안중배-
dc.contributor.author정현철-
dc.contributor.author차인호-
dc.contributor.author김기열-
dc.date.accessioned2014-12-18T08:43:58Z-
dc.date.available2014-12-18T08:43:58Z-
dc.date.issued2013-
dc.identifier.issn0022-4790-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/86851-
dc.description.abstractPURPOSE: Adjuvant chemotherapy has been known as a standard treatment for patients with resected colon cancer. However, in elderly colon cancer patients, the characteristics of patients are heterogeneous with regard to life expectancy and comorbidities. Thus, with regard to the effectiveness of adjuvant chemotherapy for colon cancer, it is difficult to extrapolate data of clinical trials from the younger into the older general population. METHODS: Data for 382 elderly colon cancer patients were analyzed: 217 in Stage II and 165 in Stage III. The efficacy of adjuvant chemotherapy was evaluated in elderly colon cancer patients after a match by the propensity score method. RESULTS: For matched patients with Stage II colon cancer, there was no significant efficacy of adjuvant chemotherapy in the risk of death during all follow-up periods (P-value, 0.06-0.37). Though there was a tendency that the adjuvant chemotherapy reduces the death rate during the follow-up periods, it was not statistically significant. In the case of Stage III, the adjuvant chemotherapy was significantly effective in matched patients for 5-year (hazard ratio [HR], 0.69; 95% confidence interval [CI], 0.30-0.90) and overall survival (HR, 0.56; 95% CI, 0.34-0.94). CONCLUSIONS: Adjuvant chemotherapy for elderly patients with Stage II colon cancer is not effective, whereas elderly patients with Stage III with adjuvant chemotherapy appear to have a better survival rate in the general population.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfJournal of Surgical Oncology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleEstimating the Adjuvant Chemotherapy Effect in Elderly Stage II and III Colon Cancer Patients in an Observational Study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorKi-Yeol Kim-
dc.contributor.googleauthorIn-Ho Cha-
dc.contributor.googleauthorJoong Bae Ahn-
dc.contributor.googleauthorNam Kyu Kim-
dc.contributor.googleauthorSun Young Rha-
dc.contributor.googleauthorHyun Cheol Chung-
dc.contributor.googleauthorJae Kyung Roh-
dc.contributor.googleauthorSang Joon Shin-
dc.identifier.doi10.1002/jso.23290-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00353-
dc.contributor.localIdA01290-
dc.contributor.localIdA02105-
dc.contributor.localIdA02262-
dc.contributor.localIdA03773-
dc.contributor.localIdA00337-
dc.contributor.localIdA04002-
dc.contributor.localIdA01316-
dc.relation.journalcodeJ01762-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1002/jso.23290/abstract-
dc.contributor.alternativeNameKim, Nam Kyu-
dc.contributor.alternativeNameRoh, Jae Kyung-
dc.contributor.alternativeNameRha, Sun Young-
dc.contributor.alternativeNameShin, Sang Joon-
dc.contributor.alternativeNameAhn, Joong Bae-
dc.contributor.alternativeNameChung, Hyun Cheol-
dc.contributor.alternativeNameCha, In Ho-
dc.contributor.alternativeNameKim, Ki Yeol-
dc.contributor.affiliatedAuthorKim, Nam Kyu-
dc.contributor.affiliatedAuthorRoh, Jae Kyung-
dc.contributor.affiliatedAuthorShin, Sang Joon-
dc.contributor.affiliatedAuthorAhn, Joong Bae-
dc.contributor.affiliatedAuthorChung, Hyun Cheol-
dc.contributor.affiliatedAuthorKim, Ki Yeol-
dc.contributor.affiliatedAuthorCha, In Ho-
dc.contributor.affiliatedAuthorRha, Sun Young-
dc.rights.accessRightsnot free-
dc.citation.volume107-
dc.citation.number6-
dc.citation.startPage613-
dc.citation.endPage618-
dc.identifier.bibliographicCitationJournal of Surgical Oncology, Vol.107(6) : 613-618, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Oral Cancer Research Institute (구강종양연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers

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