Cited 47 times in
Surgical Outcomes of Hepatocellular Carcinoma with Bile Duct Tumor Thrombus: A Korean Multicenter Study
DC Field | Value | Language |
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dc.contributor.author | 김경식 | - |
dc.contributor.author | 임진홍 | - |
dc.contributor.author | 최진섭 | - |
dc.date.accessioned | 2014-12-18T08:43:30Z | - |
dc.date.available | 2014-12-18T08:43:30Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0364-2313 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/86836 | - |
dc.description.abstract | BACKGROUND: The long-term outcomes after resection for hepatocellular carcinoma (HCC) with macroscopic bile duct tumor thrombus (BDTT) are unclear. This multicenter study was conducted to determine the prognosis of HCC patients with macroscopic BDTT who underwent resection with curative intent. METHODS: Of 4,308 patients with HCC from four Korean institutions, this single-arm retrospective study included 73 patients (1.7 %) who underwent resection for HCC with BDTT. RESULTS: Jaundice was also present in 34 patients (46.6 %). According to Ueda classification, BDTT was type 2 in 34 cases (46.6 %) and type 3 in 39 cases (53.4 %). Biliary decompression was performed in 33 patients (45.2 %), decreasing the median lowest bilirubin level to 1.4 mg/dL before surgery. Systematic hepatectomy was performed in 69 patients (94.5 %), and concurrent bile duct resection was performed in 31 patients (42.5 %). Surgical curability types were R0 (n = 57; 78.1 %), R1 (n = 11; 15.1 %), and R2 (n = 5; 6.8 %). Patient survival rates were 76.5 % at 1 year, 41.4 % at 3 years, 32.0 % at 5 years, and 17.0 % at 10 years. Recurrence rates were 42.9 % at 1 year, 70.6 % at 3 years, 77.3 % at 5 years, and 81.1 % at 10 years. Results of univariate survival analysis showed that maximal tumor size, bile duct resection, and surgical curability were significant risk factors for survival, and surgical curability was a significant risk factor for recurrence. Multivariate analysis did not reveal any independent risk factors. CONCLUSIONS: Hepatocellular carcinoma patients with BDTT achieved relatively favorable long-term results after resection; therefore extensive surgery should be recommended when complete resection is anticipated. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | WORLD JOURNAL OF SURGERY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Carcinoma, Hepatocellular/complications | - |
dc.subject.MESH | Carcinoma, Hepatocellular/mortality | - |
dc.subject.MESH | Carcinoma, Hepatocellular/surgery* | - |
dc.subject.MESH | Cholestasis/etiology* | - |
dc.subject.MESH | Cholestasis/mortality | - |
dc.subject.MESH | Cholestasis/surgery | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hepatectomy* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Liver Neoplasms/complications | - |
dc.subject.MESH | Liver Neoplasms/mortality | - |
dc.subject.MESH | Liver Neoplasms/surgery* | - |
dc.subject.MESH | Liver Transplantation | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Survival Analysis | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Surgical Outcomes of Hepatocellular Carcinoma with Bile Duct Tumor Thrombus: A Korean Multicenter Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Deok-Bog Moon | - |
dc.contributor.googleauthor | Shin Hwang | - |
dc.contributor.googleauthor | Hee-Jung Wang | - |
dc.contributor.googleauthor | Sung-Su Yun | - |
dc.contributor.googleauthor | Kyung Sik Kim | - |
dc.contributor.googleauthor | Young-Joo Lee | - |
dc.contributor.googleauthor | Ki-Hun Kim | - |
dc.contributor.googleauthor | Yong-Keun Park | - |
dc.contributor.googleauthor | Weiguang Xu | - |
dc.contributor.googleauthor | Bong-Wan Kim | - |
dc.contributor.googleauthor | Dong Shik Lee | - |
dc.contributor.googleauthor | Dong-Hyun Lee | - |
dc.contributor.googleauthor | Hong-Jin Kim | - |
dc.contributor.googleauthor | Jin Hong Lim | - |
dc.contributor.googleauthor | Jin Sub Choi | - |
dc.contributor.googleauthor | Yo-Han Park | - |
dc.contributor.googleauthor | Sung-Gyu Lee | - |
dc.identifier.doi | 10.1007/s00268-012-1845-0 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00299 | - |
dc.contributor.localId | A03411 | - |
dc.contributor.localId | A04199 | - |
dc.relation.journalcode | J02802 | - |
dc.identifier.eissn | 1432-2323 | - |
dc.identifier.pmid | 23188531 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs00268-012-1845-0 | - |
dc.subject.keyword | Obstructive Jaundice | - |
dc.subject.keyword | Tumor Thrombus | - |
dc.subject.keyword | Percutaneous Transhepatic Biliary Drainage | - |
dc.subject.keyword | Portal Vein Tumor Thrombus | - |
dc.subject.keyword | Bile Duct Resection | - |
dc.contributor.alternativeName | Kim, Kyung Sik | - |
dc.contributor.alternativeName | Lim, Jin Hong | - |
dc.contributor.alternativeName | Choi, Jin Sub | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Sik | - |
dc.contributor.affiliatedAuthor | Lim, Jin Hong | - |
dc.contributor.affiliatedAuthor | Choi, Jin Sub | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 37 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 443 | - |
dc.citation.endPage | 451 | - |
dc.identifier.bibliographicCitation | WORLD JOURNAL OF SURGERY, Vol.37(2) : 443-451, 2013 | - |
dc.identifier.rimsid | 29235 | - |
dc.type.rims | ART | - |
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