73 209

Cited 3 times in

Gastrointestinal hemorrhage after concurrent chemoradiotherapy in locally advanced pancreatic cancer

Authors
 Kyong Joo Lee  ;  Hee Man Kim  ;  Joo Won Jung  ;  Moon Jae Chung  ;  Jeong Youp Park  ;  Seungmin Bang  ;  Seung Woo Park  ;  Woo Jung Lee  ;  Jin Sil Seong  ;  Si Young Song 
Citation
 Gut and Liver, Vol.7(1) : 106-111, 2013 
Journal Title
 Gut and Liver 
ISSN
 1976-2283 
Issue Date
2013
Abstract
BACKGROUND/AIMS: While chemoradiotherapy (CRT) is considered to be a reasonable treatment for locally advanced pancreatic cancer (LAPC), there is little information about the associated risk of gastrointestinal (GI) hemorrhage. We investigated the clinical features of GI toxicity after CRT in patients with LAPC and examined the effect of GI hemorrhage on survival. METHODS: Patients enrolled in this study had received CRT for pathologically proven LAPC. Their medical records were retrospectively reviewed. RESULTS: A total of 156 patients with LAPC (median age, 65 years; range, 39 to 90 years) who received treatment between August 2005 and March 2009 were included in this study. The most common GI toxicities were ulcer formation (25.6%) and hemorrhage (25.6%), and the most common grade 3 to grade 5 GI toxicity was hemorrhage (65%). The origins of GI hemorrhage were gastric ulcer (37.5%), duodenal ulcer (37.5%), and radiation gastritis (15.0%). The independent risk factor for GI hemorrhage was tumor location in the pancreatic body. The median overall survival of the patients with a GI hemorrhage was 13.8 months (range, 2.8 to 50.8 months) and was not significantly different from that of patients without GI hemorrhage. CONCLUSIONS: GI hemorrhage was common in patients with LAPC after CRT. Although GI hemorrhage was controlled with endoscopic hemostasis, preventive measures should be investigated to reduce needless suffering.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86750
DOI
10.5009/gnl.2013.7.1.106
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
Yonsei Authors
박승우(Park, Seung Woo)
박정엽(Park, Jeong Youp)
방승민(Bang, Seungmin)
성진실(Seong, Jin Sil)
송시영(Song, Si Young)
이우정(Lee, Woo Jung)
정문재(Chung, Moon Jae)
사서에게 알리기
  feedback
Files in This Item:
T201301303.pdf Download
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse