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Clinicopathologic Features and Outcomes of Pancreatic Cysts During a 12-Year Period

Authors
 Joo Won Chung  ;  Moon Jae Chung  ;  Jeong Youp Park  ;  Seungmin Bang  ;  Si Young Song  ;  Jae Bock Chung  ;  Seung Woo Park 
Citation
 Pancreas, Vol.42(2) : 230-238, 2013 
Journal Title
 Pancreas 
ISSN
 0885-3177 
Issue Date
2013
Abstract
OBJECTIVE: Pancreatic cysts are being detected more frequently with advances in abdominal imaging. We designed this study to identify the characteristics of pancreatic cysts upon long-term follow-up and to define the proper management of them. METHODS: We identified 1386 patients diagnosed with pancreatic cysts at our hospital from 1999 to 2010 and analyzed clinicopathologic data including radiological findings. RESULTS: At initial diagnosis, 515 patients (37.2%) were classified as being at high-risk for malignancy, and 247 patients (17.8%) underwent surgery identifying 128 borderline or malignant cysts (51.8%). Borderline or malignant cysts were associated with older age, male sex, elevated serum level of lipase, carcinoembryonic antigen (CEA) or carbohydrate antigen 19-9 (CA 19-9), and a dilated pancreatic duct. Long-term follow-up for at least 24 months revealed that most of cystic lesions unchanged in size but malignant transformation was observed in 7 patients. CONCLUSIONS: Most lesions with low or indeterminate risk did not changed in size during follow-up period, but one fifth of high-risk lesions were identified as borderline or malignant after surgery. Surgical resection should be performed in patients with high-risk cysts considering their clinical condition, and radiological follow-up of nonsurgically managed cysts should be continued for more than 6 years.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86749
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00006676-201303000-00008&LSLINK=80&D=ovft
DOI
10.1097/MPA.0b013e31826ae31a
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
박승우(Park, Seung Woo)
박정엽(Park, Jeong Youp)
방승민(Bang, Seungmin) ORCID logo https://orcid.org/0000-0001-5209-8351
송시영(Song, Si Young) ORCID logo https://orcid.org/0000-0002-1417-4314
정문재(Chung, Moon Jae) ORCID logo https://orcid.org/0000-0002-5920-8549
정재복(Chung, Jae Bock)
정주원(Chung, Joo Won)
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