336 677

Cited 0 times in

High-dose Daily Opioid Administration and Poor Functional Status Intensify Local Anesthetic Injection Pain in Cancer Patients

DC Field Value Language
dc.contributor.author김신형-
dc.contributor.author윤경봉-
dc.contributor.author윤덕미-
dc.contributor.author최관웅-
dc.date.accessioned2014-12-18T08:40:29Z-
dc.date.available2014-12-18T08:40:29Z-
dc.date.issued2013-
dc.identifier.issn1533-3159-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/86745-
dc.description.abstractBACKGROUND: Evidence for opioid-induced hyperalgesia (OIH) has been shown in animal and human studies, but the clinical implications of this phenomenon remain unclear. OBJECTIVES: We examined whether cancer patients taking opioids differ in their sensitivity to a clinical pain stimulus using a local anesthetic injection compared to those not taking opioids. We also evaluated the effect of the opioid dose, duration of opioid therapy, and patients' pain severity and functional status on this clinical pain stimulus. STUDY DESIGN: Prospective observational study. SETTING: University outpatient department for interventional pain management, Republic of Korea. METHODS: Eighty-two cancer patients including 20 patients not taking opioids (non-opioid group) and 62 taking opioids (opioid group) who were scheduled for an interventional procedure were enrolled in this study. Patients received a standardized subcutaneous injection of lidocaine prior to a full dose of local anesthetic (LA). Before the injection, patients completed the Brief Pain Inventory (BPI) questionnaire and were asked to rate their current pain using numeric rating scales. Immediately following the injection, LA injection-specific pain was evaluated using pain intensity, unpleasantness, and behavior pain scores. RESULTS: LA injection-specific pain intensity, unpleasantness, and behavior pain score were significantly higher in the opioid group compared with the non-opioid group (P < 0.001). In the opioid group, these post-injection pain scores were higher in patients taking high-dose opioids than those taking low doses (P < 0.05). In addition, we observed a strong correlation between the baseline BPI pain interference score and the LA injection-specific pain score (r = 0.695, P < 0.001). LIMITATIONS: This study is limited by its sample size and observational design. Various opioid medications, which were not standardized, may have inadvertently biased our results. Finally, the pain assessed by a brief stimulus does not fully reflect disturbances in endogenous pain inhibitory processes. CONCLUSION: The results of this study suggest that opioid medication is an important contributing factor to pain perception accompanying LA injection, and cancer patients using high-dose opioids may be highly susceptible to hyperalgesic responses to this clinical stimulus. We also suggest that the possible presence of OIH may be intensified among cancer patients with poor physical and psychosocial functional status.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfPAIN PHYSICIAN-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAnalgesics, Opioid/administration & dosage*-
dc.subject.MESHAnalgesics, Opioid/adverse effects*-
dc.subject.MESHAnesthetics, Local/administration & dosage*-
dc.subject.MESHAnesthetics, Local/adverse effects*-
dc.subject.MESHDose-Response Relationship, Drug-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHHyperalgesia/chemically induced*-
dc.subject.MESHHyperalgesia/drug therapy-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasms/complications-
dc.subject.MESHObservation-
dc.subject.MESHOutpatients-
dc.subject.MESHPain/drug therapy*-
dc.subject.MESHPain/etiology-
dc.subject.MESHPain Measurement-
dc.subject.MESHProspective Studies-
dc.titleHigh-dose Daily Opioid Administration and Poor Functional Status Intensify Local Anesthetic Injection Pain in Cancer Patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology (마취통증의학)-
dc.contributor.googleauthorShin Hyung Kim-
dc.contributor.googleauthorDuck Mi Yoon-
dc.contributor.googleauthorKwan Woong Choi-
dc.contributor.googleauthorKyung Bong Yoon-
dc.identifier.doi23703423-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00676-
dc.contributor.localIdA02539-
dc.contributor.localIdA02545-
dc.contributor.localIdA04039-
dc.relation.journalcodeJ02460-
dc.identifier.eissn2150-1149-
dc.identifier.pmid23703423-
dc.subject.keywordAdverse effects-
dc.subject.keywordanalgesics-
dc.subject.keywordopioid-
dc.subject.keywordanesthetics-
dc.subject.keywordlocal-
dc.subject.keywordcancer-
dc.subject.keywordhyperalgesia-
dc.subject.keywordinjections-
dc.subject.keywordsubcutaneous-
dc.subject.keywordnociceptive pain-
dc.subject.keywordpain measurement-
dc.subject.keywordpain perception-
dc.subject.keywordquality of life-
dc.contributor.alternativeNameKim, Shin Hyung-
dc.contributor.alternativeNameYoon, Kyoung Bong-
dc.contributor.alternativeNameYoon, Duck Mi-
dc.contributor.alternativeNameChoi, Kwan Woong-
dc.contributor.affiliatedAuthorKim, Shin Hyung-
dc.contributor.affiliatedAuthorYoon, Kyoung Bong-
dc.contributor.affiliatedAuthorYoon, Duck Mi-
dc.contributor.affiliatedAuthorChoi, Kwan Woong-
dc.rights.accessRightsfree-
dc.citation.volume16-
dc.citation.number3-
dc.citation.startPage247-
dc.citation.endPage256-
dc.identifier.bibliographicCitationPAIN PHYSICIAN, Vol.16(3) : 247-256, 2013-
dc.identifier.rimsid29177-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.