Cited 12 times in
Levonorgestrel-releasing intrauterine system versus conventional medical therapy for heavy menstrual bleeding in the Asia-Pacific region
DC Field | Value | Language |
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dc.contributor.author | 이병석 | - |
dc.date.accessioned | 2014-12-18T08:39:24Z | - |
dc.date.available | 2014-12-18T08:39:24Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0020-7292 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/86712 | - |
dc.description.abstract | OBJECTIVE: To compare clinical outcomes, including cumulative continuation rate (CCR), in the treatment of idiopathic heavy menstrual bleeding (HMB) with the levonorgestrel-releasing intrauterine system (LNG-IUS) and with conventional medical therapies (CMTs), including combined oral contraceptives, oral progestins, and antifibrinolytics, either alone or in combination, in the Asia-Pacific region. METHODS: In a prospective observational cohort study conducted between September 2008 and December 2010, 647 women (LNG-IUS, n=483; CMTs, n=164), aged 18-45 years and diagnosed with HMB, were recruited from 8 countries and followed for up to 1 year. The primary outcome was the CCR at 12 months. Secondary outcomes included bleeding pattern, an assessment of treatment efficacy by the treating physician, and safety. RESULTS: The CCR at 12 months was significantly higher for LNG-IUS than for CMTs (87.6% vs 56.3% P<0.05). Compared with CMTs, LNG-IUS offered a better reduction in both subjectively assessed menstrual blood loss and the number of bleeding days, and had better efficacy for HMB, as determined by the physician's final evaluation. CONCLUSION: The present study provides information on the real-life patterns of treatment of HMB in the Asia-Pacific region. The efficacy of CMTs was inferior compared with LNG-IUS in the clinical outcomes measured. ClinicalTrials.gov:NCT00864136. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Antifibrinolytic Agents/therapeutic use | - |
dc.subject.MESH | Asia | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Contraceptive Agents, Female/administration & dosage | - |
dc.subject.MESH | Contraceptive Agents, Female/therapeutic use* | - |
dc.subject.MESH | Contraceptives, Oral, Combined/therapeutic use | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Intrauterine Devices, Medicated* | - |
dc.subject.MESH | Levonorgestrel/administration & dosage | - |
dc.subject.MESH | Levonorgestrel/therapeutic use* | - |
dc.subject.MESH | Menorrhagia/drug therapy* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Progestins/therapeutic use | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Young Adult | - |
dc.title | Levonorgestrel-releasing intrauterine system versus conventional medical therapy for heavy menstrual bleeding in the Asia-Pacific region | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics & Gynecology (산부인과학) | - |
dc.contributor.googleauthor | Byung S. Lee | - |
dc.contributor.googleauthor | Xu Ling | - |
dc.contributor.googleauthor | Shaheena Asif | - |
dc.contributor.googleauthor | Peter Kraemer | - |
dc.contributor.googleauthor | Jens U. Hanisch | - |
dc.contributor.googleauthor | Pirjo Inki | - |
dc.identifier.doi | 10.1016/j.ijgo.2012.10.028 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02795 | - |
dc.relation.journalcode | J01117 | - |
dc.identifier.eissn | 1879-3479 | - |
dc.identifier.pmid | 23340271 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0020729212006674 | - |
dc.subject.keyword | Adolescent | - |
dc.subject.keyword | Adult | - |
dc.subject.keyword | Antifibrinolytic Agents/therapeutic use | - |
dc.subject.keyword | Asia | - |
dc.subject.keyword | Cohort Studies | - |
dc.subject.keyword | Contraceptive Agents, Female/administration & dosage | - |
dc.subject.keyword | Contraceptive Agents, Female/therapeutic use* | - |
dc.subject.keyword | Contraceptives, Oral, Combined/therapeutic use | - |
dc.subject.keyword | Female | - |
dc.subject.keyword | Follow-Up Studies | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Intrauterine Devices, Medicated* | - |
dc.subject.keyword | Levonorgestrel/administration & dosage | - |
dc.subject.keyword | Levonorgestrel/therapeutic use* | - |
dc.subject.keyword | Menorrhagia/drug therapy* | - |
dc.subject.keyword | Middle Aged | - |
dc.subject.keyword | Progestins/therapeutic use | - |
dc.subject.keyword | Prospective Studies | - |
dc.subject.keyword | Treatment Outcome | - |
dc.subject.keyword | Young Adult | - |
dc.contributor.alternativeName | Lee, Byung Seok | - |
dc.contributor.affiliatedAuthor | Lee, Byung Seok | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 121 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 24 | - |
dc.citation.endPage | 30 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, Vol.121(1) : 24-30, 2013 | - |
dc.identifier.rimsid | 29156 | - |
dc.type.rims | ART | - |
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