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Levonorgestrel-releasing intrauterine system versus conventional medical therapy for heavy menstrual bleeding in the Asia-Pacific region

Authors
 Byung S. Lee  ;  Xu Ling  ;  Shaheena Asif  ;  Peter Kraemer  ;  Jens U. Hanisch  ;  Pirjo Inki 
Citation
 INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, Vol.121(1) : 24-30, 2013 
Journal Title
 INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS 
ISSN
 0020-7292 
Issue Date
2013
MeSH
Adolescent ; Adult ; Antifibrinolytic Agents/therapeutic use ; Asia ; Cohort Studies ; Contraceptive Agents, Female/administration & dosage ; Contraceptive Agents, Female/therapeutic use* ; Contraceptives, Oral, Combined/therapeutic use ; Female ; Follow-Up Studies ; Humans ; Intrauterine Devices, Medicated* ; Levonorgestrel/administration & dosage ; Levonorgestrel/therapeutic use* ; Menorrhagia/drug therapy* ; Middle Aged ; Progestins/therapeutic use ; Prospective Studies ; Treatment Outcome ; Young Adult
Keywords
Adolescent ; Adult ; Antifibrinolytic Agents/therapeutic use ; Asia ; Cohort Studies ; Contraceptive Agents, Female/administration & dosage ; Contraceptive Agents, Female/therapeutic use* ; Contraceptives, Oral, Combined/therapeutic use ; Female ; Follow-Up Studies ; Humans ; Intrauterine Devices, Medicated* ; Levonorgestrel/administration & dosage ; Levonorgestrel/therapeutic use* ; Menorrhagia/drug therapy* ; Middle Aged ; Progestins/therapeutic use ; Prospective Studies ; Treatment Outcome ; Young Adult
Abstract
OBJECTIVE: To compare clinical outcomes, including cumulative continuation rate (CCR), in the treatment of idiopathic heavy menstrual bleeding (HMB) with the levonorgestrel-releasing intrauterine system (LNG-IUS) and with conventional medical therapies (CMTs), including combined oral contraceptives, oral progestins, and antifibrinolytics, either alone or in combination, in the Asia-Pacific region. METHODS: In a prospective observational cohort study conducted between September 2008 and December 2010, 647 women (LNG-IUS, n=483; CMTs, n=164), aged 18-45 years and diagnosed with HMB, were recruited from 8 countries and followed for up to 1 year. The primary outcome was the CCR at 12 months. Secondary outcomes included bleeding pattern, an assessment of treatment efficacy by the treating physician, and safety. RESULTS: The CCR at 12 months was significantly higher for LNG-IUS than for CMTs (87.6% vs 56.3% P<0.05). Compared with CMTs, LNG-IUS offered a better reduction in both subjectively assessed menstrual blood loss and the number of bleeding days, and had better efficacy for HMB, as determined by the physician's final evaluation. CONCLUSION: The present study provides information on the real-life patterns of treatment of HMB in the Asia-Pacific region. The efficacy of CMTs was inferior compared with LNG-IUS in the clinical outcomes measured. ClinicalTrials.gov:NCT00864136.
Full Text
http://www.sciencedirect.com/science/article/pii/S0020729212006674
DOI
10.1016/j.ijgo.2012.10.028
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Byung Seok(이병석) ORCID logo https://orcid.org/0000-0001-6001-2079
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86712
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