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Late respiratory infection after lung transplantation

 Sang Young Kim  ;  Jung Ar Shin  ;  Eun Na Cho  ;  Min Kwang Byun  ;  Hyung Jung Kim  ;  Chul Min Ahn  ;  Suk Jin Haam  ;  Doo Yun Lee  ;  Hyo Chae Paik  ;  Yoon Soo Chang 
 Tuberculosis and Respiratory Diseases, Vol.74(2) : 63-69, 2013 
Journal Title
 Tuberculosis and Respiratory Diseases 
Issue Date
Background : Aiming to improve outcome of lung transplantation (LTx) patients, we reviewed risk factors and treatment practices for the LTx recipients who experienced respiratory infection in the late post-LTx period (>1 month after LTx). Materials and Methods : We analyzed the clinical data of 48 recipients and donors from 61 LTx, who experienced late respiratory infections. Late respiratory infections were classified according to the etiology, time of occurrence, and frequency of donor-to-host transmission or colonization of the recipient prior to transplantation. Results : During the period of observation, 42 episodes of respiratory infections occurred. The organisms most frequently involved were gram (−) bacteria: Acinetobacter baumannii (n=13, 31.0%), Pseudomonas aeruginosa (n=7, 16.7%), and Klebsiella pneumoniae (n=4, 10.0%). Among the 42 episodes recorded, 14 occurred in the late post-LTx period. These were bacterial (n=6, 42.9%), fungal (n=2, 14.3%), viral (n=4, 28.5%), and mycobacterial (n=2, 14.3%) infections. Of 6 bacterial infections, 2 were from multidrug-resistant (MDR) A. baumannii and one from each of MDR P. aeruginosa, extended spectrum β-lactamase (+) K. pneumoniae, methicillin-resistant Staphylococcus aureus and Streptococcus pneumoniae. Infection-related death occurred in 6 of the 14 episodes (43%). Conclusion : Although the frequency of respiratory infection decreased sharply in the late post-LTx period, respiratory infection was still a major cause of mortality. Gram (−) MDR bacteria were the agents most commonly identified in these infections.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김상용(Kim, Sang Young)
김형중(Kim, Hyung Jung) ORCID logo https://orcid.org/0000-0003-2498-0683
백효채(Paik, Hyo Chae) ORCID logo https://orcid.org/0000-0001-9309-8235
변민광(Byun, Min Kwang) ORCID logo https://orcid.org/0000-0003-1525-1745
신정아(Shin, Jung Ar)
안철민(Ahn, Chul Min)
이두연(Lee, Doo Yun)
장윤수(Chang, Yoon Soo)
함석진(Haam, Seok Jin)
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