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Comparison of Early Clinical Outcomes Following Transcatheter Aortic Valve Implantation versus Surgical Aortic Valve Replacement versus Optimal Medical Therapy in Patients Older than 80 Years with Symptomatic Severe Aortic Stenosis

DC FieldValueLanguage
dc.contributor.author신동호-
dc.contributor.author최동훈-
dc.contributor.author심재광-
dc.contributor.author홍명기-
dc.contributor.author심지영-
dc.contributor.author이삭-
dc.contributor.author고영국-
dc.contributor.author임의-
dc.contributor.author곽영란-
dc.contributor.author장병철-
dc.contributor.author김병극-
dc.contributor.author장양수-
dc.contributor.author김중선-
dc.contributor.author장혁재-
dc.date.accessioned2014-12-18T08:37:47Z-
dc.date.available2014-12-18T08:37:47Z-
dc.date.issued2013-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/86662-
dc.description.abstractPURPOSE: Transcatheter aortic valve implantation (TAVI) has become an attractive therapeutic strategy for severe aortic stenosis (AS) in elderly patients due to its minimally-invasive nature. Therefore, early results of its clinical outcomes in elderly Korean patients were evaluated. MATERIALS AND METHODS: We compared early clinical outcomes of TAVI, surgical aortic valve replacement (SAVR), and optimal medical therapy (OMT) in patients aged≥80 years with symptomatic severe AS. Treatment groups were allocated as follows: TAVI (n=10), SAVR (n=14), and OMT (n=42). RESULTS: Baseline clinical characteristics including predicted operative mortality were similar among the three groups. However, patients with New York Heart Association functional class III or IV symptoms and smaller aortic valve area were treated with TAVI or SAVR rather than OMT. In-hospital combined safety endpoints (all-cause mortality, major stroke, peri-procedural myocardial infarction, life-threatening bleeding, major vascular complication, and acute kidney injury) after TAVI or SAVR were significantly lower in the TAVI group than in the SAVR group (10.0% vs. 71.4%, respectively, p=0.005), along with an acceptable rate of symptom improvement and device success. During the follow-up period, the TAVI group showed the lowest rate of 3-month major adverse cardiovascular and cerebrovascular events, a composite of all-cause mortality, myocardial infarction, major stroke, and re-hospitalization (TAVI 0.0% vs. SAVR 50.0% vs. OMT 42.9%, p=0.017). CONCLUSION: Treatment with TAVI was associated with lower event rates compared to SAVR or OMT. Therefore, TAVI may be considered as the first therapeutic strategy in selected patients aged≥80 years with symptomatic severe AS.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAge Factors-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAortic Valve/surgery*-
dc.subject.MESHAortic Valve Stenosis/diagnosis-
dc.subject.MESHAortic Valve Stenosis/surgery*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHPrognosis-
dc.subject.MESHRisk Factors-
dc.subject.MESHTreatment Outcome-
dc.titleComparison of Early Clinical Outcomes Following Transcatheter Aortic Valve Implantation versus Surgical Aortic Valve Replacement versus Optimal Medical Therapy in Patients Older than 80 Years with Symptomatic Severe Aortic Stenosis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorEui Im-
dc.contributor.googleauthorMyeong-Ki Hong-
dc.contributor.googleauthorYoung-Guk Ko-
dc.contributor.googleauthorDong-Ho Shin-
dc.contributor.googleauthorJung-Sun Kim-
dc.contributor.googleauthorByeong-Keuk Kim-
dc.contributor.googleauthorDonghoon Choi-
dc.contributor.googleauthorChi Young Shim-
dc.contributor.googleauthorHyuk-Jae Chang-
dc.contributor.googleauthorJae-Kwang Shim-
dc.contributor.googleauthorYoung-Lan Kwak-
dc.contributor.googleauthorSak Lee-
dc.contributor.googleauthorByung-Chul Chang-
dc.contributor.googleauthorYangsoo Jang-
dc.identifier.doi10.3349/ymj.2013.54.3.596-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02097-
dc.contributor.localIdA04053-
dc.contributor.localIdA02205-
dc.contributor.localIdA04391-
dc.contributor.localIdA02213-
dc.contributor.localIdA02807-
dc.contributor.localIdA00127-
dc.contributor.localIdA03394-
dc.contributor.localIdA00172-
dc.contributor.localIdA03430-
dc.contributor.localIdA00493-
dc.contributor.localIdA03448-
dc.contributor.localIdA00961-
dc.contributor.localIdA03490-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid23549802-
dc.subject.keywordAortic stenosis-
dc.subject.keywordtranscatheter aortic valve implantation-
dc.subject.keywordtreatment outcome-
dc.contributor.alternativeNameShin, Dong Ho-
dc.contributor.alternativeNameChoi, Dong Hoon-
dc.contributor.alternativeNameShim, Jae Kwang-
dc.contributor.alternativeNameHong, Myeong Ki-
dc.contributor.alternativeNameShim, Chi Young-
dc.contributor.alternativeNameLee, Sak-
dc.contributor.alternativeNameKo, Young Guk-
dc.contributor.alternativeNameIm, Eui-
dc.contributor.alternativeNameKwak, Young Lan-
dc.contributor.alternativeNameChang, Byung Chul-
dc.contributor.alternativeNameKim, Byeong Keuk-
dc.contributor.alternativeNameJang, Yang Soo-
dc.contributor.alternativeNameKim, Jung Sun-
dc.contributor.alternativeNameChang, Hyuck Jae-
dc.contributor.affiliatedAuthorShin, Dong Ho-
dc.contributor.affiliatedAuthorChoi, Dong Hoon-
dc.contributor.affiliatedAuthorShim, Jae Kwang-
dc.contributor.affiliatedAuthorHong, Myeong Ki-
dc.contributor.affiliatedAuthorShim, Chi Young-
dc.contributor.affiliatedAuthorLee, Sak-
dc.contributor.affiliatedAuthorKo, Young Guk-
dc.contributor.affiliatedAuthorIm, Eui-
dc.contributor.affiliatedAuthorKwak, Young Lan-
dc.contributor.affiliatedAuthorChang, Byung Chul-
dc.contributor.affiliatedAuthorKim, Byeong Keuk-
dc.contributor.affiliatedAuthorJang, Yang Soo-
dc.contributor.affiliatedAuthorKim, Jung Sun-
dc.contributor.affiliatedAuthorChang, Hyuck Jae-
dc.rights.accessRightsfree-
dc.citation.volume54-
dc.citation.number3-
dc.citation.startPage596-
dc.citation.endPage602-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.54(3) : 596-602, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers

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