Cited 107 times in
Prognostic Implications for High Expression of Oncogenic microRNAs in Advanced Gastric Carcinoma
DC Field | Value | Language |
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dc.contributor.author | 홍순원 | - |
dc.contributor.author | 윤선옥 | - |
dc.contributor.author | 최승호 | - |
dc.date.accessioned | 2014-12-18T08:33:21Z | - |
dc.date.available | 2014-12-18T08:33:21Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0022-4790 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/86527 | - |
dc.description.abstract | BACKGROUND: Aberrant expressions of specific microRNAs are recently known in many malignancies, including gastric carcinoma. The prognostic implication of oncogenic microRNA dysregulation was investigated in advanced gastric carcinomas undergoing radical resection and adjuvant systemic chemotherapy, and observed on long-term follow-up. METHODS: The expression levels of miR-20a, miR-21, miR-25, miR-93, miR-103, miR-106a, miR-106b, miR-130b, miR-155, miR-221, and miR-222 were analyzed in formalin-fixed paraffin-embedded (FFPE) cancer tissues of 91 patients, using reverse transcription real-time PCR. RESULTS: The high expression of miR-20a, miR-25, miR-93, miR-103, miR-106a, miR-106b, miR-130 was associated with lymph node metastasis (P < 0.05), and high expression of miR-155 was related to tumor penetration through serosa and lymph node metastasis (P < 0.05). Cases with high expression of miR-222 (P = 0.014) showed reduced 5-year survival rates. The high expression of miR-222 and miR-221 showed correlation with shorter metastasis-free survival (P = 0.039 and 0.033, respectively), and miR-222 high expression was related to reduced overall survival (P = 0.012). CONCLUSIONS: The high expression of miR-20a, miR-25, miR-93, miR-103, miR-106a, miR-106b, miR-130, miR-155, miR-221, and miR-222 in AGC tissues may be a high risk factor associated with tumor penetration through serosa, lymph node metastasis, distant metastasis, and poor long-term survival in patients undergoing radical resection and adjuvant systemic chemotherapy. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JOURNAL OF SURGICAL ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Carcinoma/genetics* | - |
dc.subject.MESH | Carcinoma/mortality* | - |
dc.subject.MESH | Carcinoma/pathology | - |
dc.subject.MESH | Carcinoma/therapy | - |
dc.subject.MESH | Chemotherapy, Adjuvant | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Gastrectomy | - |
dc.subject.MESH | Gene Expression Profiling | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lymphatic Metastasis | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | MicroRNAs/analysis* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Neoplasm Metastasis | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Stomach Neoplasms/genetics* | - |
dc.subject.MESH | Stomach Neoplasms/mortality* | - |
dc.subject.MESH | Stomach Neoplasms/pathology | - |
dc.subject.MESH | Stomach Neoplasms/therapy | - |
dc.title | Prognostic Implications for High Expression of Oncogenic microRNAs in Advanced Gastric Carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Baek-Hui Kim | - |
dc.contributor.googleauthor | Soon Won Hong | - |
dc.contributor.googleauthor | Aeree Kim | - |
dc.contributor.googleauthor | Seung Ho Choi | - |
dc.contributor.googleauthor | Sun Och Yoon | - |
dc.identifier.doi | 10.1002/jso.23271 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04102 | - |
dc.contributor.localId | A04411 | - |
dc.contributor.localId | A02566 | - |
dc.relation.journalcode | J01762 | - |
dc.identifier.eissn | 1096-9098 | - |
dc.identifier.pmid | 22996433 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/jso.23271/abstract | - |
dc.subject.keyword | microRNA | - |
dc.subject.keyword | advanced gastric carcinoma | - |
dc.subject.keyword | prognosis | - |
dc.contributor.alternativeName | Hong, Soon Won | - |
dc.contributor.alternativeName | Yoon, Sun Och | - |
dc.contributor.alternativeName | Choi, Seung Ho | - |
dc.contributor.affiliatedAuthor | Choi, Seung Ho | - |
dc.contributor.affiliatedAuthor | Hong, Soon Won | - |
dc.contributor.affiliatedAuthor | Yoon, Sun Och | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 107 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 505 | - |
dc.citation.endPage | 510 | - |
dc.identifier.bibliographicCitation | JOURNAL OF SURGICAL ONCOLOGY, Vol.107(5) : 505-510, 2013 | - |
dc.identifier.rimsid | 29036 | - |
dc.type.rims | ART | - |
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