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Left Ventricular Global Function Index By Magnetic Resonance Imaging- A Novel Marker for Assessment of Cardiac Performance for the Prediction Of Cardiovascular Events: The Multi-Ethnic Study of Atherosclerosis

Authors
 Nathan Mewton  ;  Anders Opdahl  ;  Eui-Young Choi  ;  Andre L. C. Almeida  ;  Nadine Kawel  ;  Colin O. Wu  ;  Gregory L. Burke  ;  Songtao Liu  ;  Kiang Liu  ;  David A. Bluemke  ;  Joao A. C. Lima 
Citation
 Hypertension, Vol.61(4) : 770-778, 2013 
Journal Title
 Hypertension 
ISSN
 0194-911X 
Issue Date
2013
Abstract
Left ventricular (LV) function is generally assessed independent of structural remodeling and vice versa. The purpose of this study was to evaluate a novel LV global function index (LVGFI) that integrates LV structure with global function and to assess its predictive value for cardiovascular (CV) events throughout adult life in a multiethnic population of men and women without history of CV diseases at baseline. A total of 5004 participants in the Multi-Ethnic Study of Atherosclerosis underwent a cardiac magnetic resonance study and were followed up for a median of 7.2 years. The LVGFI by cardiac magnetic resonance was defined by the ratio of stroke volume divided by LV total volume defined as the sum of mean LV cavity and myocardial volumes. Cox proportional hazard models were constructed to predict the end points of heart failure, hard CV events, and a combined end point of all CV events after adjustment for established risk factors, calcium score, and biomarkers. A total of 579 (11.6%) CV events were observed during the follow-up period. In adjusted models, the end points of heart failure, hard CV events, and all events were all significantly associated with LVGFI (heart failure, hazard ratio=0.64, P<0.0001; hard CV events, hazard ratio=0.79, P=0.007; all events, hazard ratio=0.79, P<0.0001). LVGFI had a significant independent predictive value in the multivariable models for all CV event categories. The LVGFI was a powerful predictor of incident HF, hard CV events, and a composite end point, including all events in this multiethnic cohort.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86507
Files in This Item:
T201300611.pdf Download
DOI
10.1161/HYPERTENSIONAHA.111.198028
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
최의영(Choi, Eui Young)
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