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Usefulness of Ki-67 (MIB-1) immunostaining in the diagnosis of pulmonary sclerosing hemangiomas

DC Field Value Language
dc.contributor.author김세훈-
dc.contributor.author윤선옥-
dc.contributor.author홍순원-
dc.date.accessioned2014-12-18T08:31:16Z-
dc.date.available2014-12-18T08:31:16Z-
dc.date.issued2013-
dc.identifier.issn0903-4641-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/86463-
dc.description.abstractPulmonary sclerosing hemangioma (PSH) is an uncommon lung neoplasm with a clinical outcome that is generally benign. However, differentiating PSH from pulmonary carcinoma is sometimes difficult as both lesions share similar histopathologic and immunohistochemical features. In this study, we investigated the usefulness of Ki-67 (MIB-1) immunostaining in the diagnosis of PSH. We compared the staining pattern for Ki-67 (MIB-1) in 29 cases of typical PSH and 79 cases of pulmonary non-small cell carcinoma (NSCLC) using an immunohistochemical method on formalin-fixed paraffin-embedded tissues. In all studied PSH cases, we noted cell membrane and cytoplasmic staining for Ki-67 (MIB-1), but this was not observed in any of the NSCLC cases. The Ki-67 proliferation index was lower in PSH than in the NSCLC cases (mean, 1.1% vs mean, 5.5%; p < 0.001). These findings suggest that cell membrane and cytoplasmic staining for Ki-67 (MIB-1), as well as the Ki-67 proliferation index, may be useful for distinguishing PSH from pulmonary carcinoma.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfAPMIS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleUsefulness of Ki-67 (MIB-1) immunostaining in the diagnosis of pulmonary sclerosing hemangiomas-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorBaek-hui Kim-
dc.contributor.googleauthorYoon-sung Bae-
dc.contributor.googleauthorSe Hoon Kim-
dc.contributor.googleauthorHyeong-jae Jeong-
dc.contributor.googleauthorSoon Won Hong-
dc.contributor.googleauthorSun Och Yoon-
dc.identifier.doi10.1111/j.1600-0463.2012.02945.x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00610-
dc.contributor.localIdA02566-
dc.contributor.localIdA04411-
dc.relation.journalcodeJ00194-
dc.identifier.eissn1600-0463-
dc.identifier.pmidPulmonary sclerosing hemangioma ; Ki-67 antigen ; MIB-1 antibody ; immunohistochemistry-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1600-0463.2012.02945.x/abstract-
dc.subject.keywordPulmonary sclerosing hemangioma-
dc.subject.keywordKi-67 antigen-
dc.subject.keywordMIB-1 antibody-
dc.subject.keywordimmunohistochemistry-
dc.contributor.alternativeNameKim, Se Hoon-
dc.contributor.alternativeNameYoon, Sun Och-
dc.contributor.alternativeNameHong, Soon Won-
dc.contributor.affiliatedAuthorKim, Se Hoon-
dc.contributor.affiliatedAuthorYoon, Sun Och-
dc.contributor.affiliatedAuthorHong, Soon Won-
dc.rights.accessRightsnot free-
dc.citation.volume121-
dc.citation.number2-
dc.citation.startPage105-
dc.citation.endPage110-
dc.identifier.bibliographicCitationAPMIS, Vol.121(2) : 105-110, 2013-
dc.identifier.rimsid28996-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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