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The Effect of the Menstrual Cycle on Inflammatory Bowel Disease: A Prospective Study

Authors
 Sun Min Lim  ;  Chung Mo Nam  ;  Youn Nam Kim  ;  Sin Ae Lee  ;  Eun Hye Kim  ;  Sung Pil Hong  ;  Tae Il Kim  ;  Won Ho Kim  ;  Jae Hee Cheon 
Citation
 Gut and Liver, Vol.7(1) : 51-57, 2013 
Journal Title
 Gut and Liver 
ISSN
 1976-2283 
Issue Date
2013
Abstract
BACKGROUND/AIMS: The symptoms of inflammatory bowel disease (IBD) fluctuate considerably over time. However, it has not been determined whether these symptoms are affected by the menstrual cycle in female IBD patients. This study analyzed the effects of the menstrual cycle on IBD symptom variation. METHODS: This was a prospective study of 91 study subjects (47 IBD patients and 44 healthy controls) who reported daily symptoms and signs throughout their menstrual cycles. RESULTS: IBD patients had significantly more frequent gastrointestinal symptoms, such as nausea (30% vs 7%, p=0.006), flatulence (53% vs 22%, p=0.003), and abdominal pain as compared to controls (68% vs 38%, p=0.006). The IBD patients also experienced more frequent systemic premenstrual symptoms than the controls (79% vs 50%, p=0.003). More severe abdominal pain (p=0.002) and lower mean general condition scores (p=0.001) were noted during the menstrual phase as compared to the pre- or post-menstrual phase in both groups. IBD patients experienced more frequent premenstrual gastrointestinal symptoms than controls, but their IBD symptoms did not change significantly during the menstrual cycle. CONCLUSIONS: Knowledge of the cyclic alterations in gastrointestinal and systemic symptoms may be helpful in determining the true exacerbation of disease in female IBD patients.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86427
Files in This Item:
T201300449.pdf Download
DOI
10.5009/gnl.2013.7.1.51
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실)
Yonsei Authors
김원호(Kim, Won Ho)
김윤남(Kim, Youn Nam)
김은혜(Kim, Eun Hye)
김태일(Kim, Tae Il)
남정모(Nam, Jung Mo) ORCID logo https://orcid.org/0000-0003-0985-0928
임선민(Lim, Sun Min)
천재희(Cheon, Jae Hee)
홍성필(Hong, Sung Pil)
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