Cited 11 times in
Induction of cytokines and growth factors by rapamycin in the microenvironment of brain metastases of lung cancer
DC Field | Value | Language |
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dc.contributor.author | 김세훈 | - |
dc.date.accessioned | 2014-12-18T08:29:35Z | - |
dc.date.available | 2014-12-18T08:29:35Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1792-1074 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/86410 | - |
dc.description.abstract | The association between rapamycin and astrocytes in a tumor-bearing mouse model with brain metastases of non-small cell lung cancer (NSCLC) was investigated. For in vitro experiments, NCI-H358, a human lung adenocarcinoma cell line, was co-cultured with immortalized astrocytes, and treated with rapamycin, an mTOR inhibitor. We evaluated the expression of interleukin-1 (IL-1), interleukin-3 (IL-3), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), transforming growth factor-β (TGF-β), insulin-like growth factor-1 (IGF-1), platelet-derived growth factor (PDGF), chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1 (MIP-1) in tumor cells in vivo. Rapamycin is cytotoxic in vitro; however, co-culturing tumor cells and astrocytes induced tumor cell survival. IL-1, IL-3, IL-6, TNF-α, TGF-β, PDGF, MCP-1 and MIP-1 expression were higher in rapamycin-treated mice compared to the control group, however, IGF-1 expression was lower. Notably, treatment with rapamycin before inoculating tumor cells affected cytokine expression in the tumor microenvironment. We suggest that growth factors and cytokines in the tumor microenvironment play a role in the survival of cancer cells in brain metastases. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | ONCOLOGY LETTERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Induction of cytokines and growth factors by rapamycin in the microenvironment of brain metastases of lung cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | SE HOON KIM | - |
dc.contributor.googleauthor | JUNG EUN LEE | - |
dc.contributor.googleauthor | SEUNG-HO YANG | - |
dc.contributor.googleauthor | SANG WON LEE | - |
dc.identifier.doi | 10.3892/ol.2013.1135 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00610 | - |
dc.relation.journalcode | J02417 | - |
dc.identifier.eissn | 1792-1082 | - |
dc.identifier.pmid | 23426399 | - |
dc.subject.keyword | astrocytes | - |
dc.subject.keyword | brain metastasis | - |
dc.subject.keyword | microenvironment | - |
dc.subject.keyword | non-small cell lung cancer | - |
dc.subject.keyword | rapamycin | - |
dc.contributor.alternativeName | Kim, Se Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Se Hoon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 5 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 953 | - |
dc.citation.endPage | 958 | - |
dc.identifier.bibliographicCitation | ONCOLOGY LETTERS, Vol.5(3) : 953-958, 2013 | - |
dc.identifier.rimsid | 28965 | - |
dc.type.rims | ART | - |
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