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Effect of Cilostazol in Acute Lacunar Infarction Based on Pulsatility Index of Transcranial Doppler (ECLIPse): A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial

DC FieldValueLanguage
dc.contributor.author김원주-
dc.contributor.author남효석-
dc.contributor.author이경열-
dc.date.accessioned2014-12-18T08:26:41Z-
dc.date.available2014-12-18T08:26:41Z-
dc.date.issued2013-
dc.identifier.issn0014-3022-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/86318-
dc.description.abstractBACKGROUND: This study is intended to evaluate the propensities of cilostazol to reduce the pulsatility index (PI) in patients with acute lacunar infarction using the serial transcranial Doppler (TCD) examinations. METHODS: In a multicenter, randomized, double-blind, placebo-controlled trial, patients were randomly assigned to receive either placebo or 100 mg cilostazol twice a day as well as aspirin 100 mg a day. The primary outcomes were the changes of middle cerebral artery (MCA) and basilar artery (BA) PIs at 14 and 90 days from the baseline TCD study. This study is registered with ClinicalTrials.gov (NCT00741286). RESULTS: Trial medication was given to 203 patients, with 100 receiving cilostazol and 103 receiving placebo, and 164 were included in the per-protocol analysis of the primary outcome. Results from the linear mixed model showed that significant effects were obtained for time-by-group interactions (p = 0.008 in right MCA, p = 0.015 in left MCA, p = 0.002 in BA), suggesting that changes of PIs from the baseline to the 90-day study were different across the groups. CONCLUSIONS: Cilostazol further decreased TCD PIs at 90 days from baseline compared to placebo in acute lacunar infarction. This result may be related to pleiotropic effects, such as vasodilation, beyond its antiplatelet activity.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfEUROPEAN NEUROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAspirin/therapeutic use*-
dc.subject.MESHDouble-Blind Method-
dc.subject.MESHDrug Therapy, Combination-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPhosphodiesterase Inhibitors/therapeutic use*-
dc.subject.MESHPlatelet Aggregation Inhibitors/therapeutic use*-
dc.subject.MESHPulse Wave Analysis-
dc.subject.MESHStroke, Lacunar/diagnostic imaging-
dc.subject.MESHStroke, Lacunar/drug therapy*-
dc.subject.MESHTetrazoles/therapeutic use*-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHUltrasonography, Doppler, Transcranial-
dc.titleEffect of Cilostazol in Acute Lacunar Infarction Based on Pulsatility Index of Transcranial Doppler (ECLIPse): A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학)-
dc.contributor.googleauthorHan SW-
dc.contributor.googleauthorLee SS-
dc.contributor.googleauthorKim SH-
dc.contributor.googleauthorLee JH-
dc.contributor.googleauthorKim GS-
dc.contributor.googleauthorKim OJ-
dc.contributor.googleauthorKoh IS-
dc.contributor.googleauthorLee JY-
dc.contributor.googleauthorSuk SH-
dc.contributor.googleauthorLee SI-
dc.contributor.googleauthorNam HS-
dc.contributor.googleauthorKim WJ-
dc.contributor.googleauthorYong SW-
dc.contributor.googleauthorLee KY-
dc.contributor.googleauthorPark JH-
dc.identifier.doi10.1159/000338247-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00325-
dc.contributor.localIdA00771-
dc.contributor.localIdA01273-
dc.contributor.localIdA02648-
dc.contributor.localIdA03182-
dc.relation.journalcodeJ00849-
dc.identifier.eissn1421-9913-
dc.identifier.pmid23128968-
dc.identifier.urlhttp://www.karger.com/Article/FullText/338247-
dc.subject.keywordAntiplatelet activity-
dc.subject.keywordLacunar infarcts-
dc.subject.keywordTranscranial Doppler-
dc.subject.keywordPulsatility index-
dc.subject.keywordCilostazol-
dc.contributor.alternativeNameKim, Gyu Sik-
dc.contributor.alternativeNameKim, Won Joo-
dc.contributor.alternativeNameNam, Hyo Suk-
dc.contributor.alternativeNameLee, Kyung Yul-
dc.contributor.alternativeNameLee, Jun Hong-
dc.contributor.affiliatedAuthorKim, Gyu Sik-
dc.contributor.affiliatedAuthorKim, Won Joo-
dc.contributor.affiliatedAuthorNam, Hyo Suk-
dc.contributor.affiliatedAuthorLee, Kyung Yul-
dc.contributor.affiliatedAuthorLee, Jun Hong-
dc.rights.accessRightsnot free-
dc.citation.volume69-
dc.citation.number1-
dc.citation.startPage33-
dc.citation.endPage40-
dc.identifier.bibliographicCitationEUROPEAN NEUROLOGY, Vol.69(1) : 33-40, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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