Cited 5 times in
Rapid Decrease of Intact Parathyroid Hormone Could Be a Predictor of Better Response to Cinacalcet in Hemodialysis Patients
DC Field | Value | Language |
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dc.contributor.author | 최규헌 | - |
dc.date.accessioned | 2014-12-18T08:25:31Z | - |
dc.date.available | 2014-12-18T08:25:31Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/86281 | - |
dc.description.abstract | PURPOSE: Cinacalcet is effective for treating refractory secondary hyperparathyroidism (SHPT), but little is known about the response rates and clinical factors influencing the response. MATERIALS AND METHODS: A prospective, single-arm, multi-center study was performed for 24 weeks. Cinacalcet was administered to patients with intact parathyroid hormone (iPTH) level greater than 300 pg/mL. Cinacalcet was started at a dose of 25 mg daily and titrated until 100 mg to achieve a serum iPTH level<300 pg/mL (primary end point). Early response to cinacalcet was defined as a decrease of iPTH more than 50% within one month. RESULTS: Fifty-seven patients were examined. Based on the magnitude of iPTH decrease, patients were divided into responder (n=47, 82.5%) and non-responder (n=10, 17.5%) groups. Among the responders, 38 achieved the primary end point, whereas 9 patients showed a reduction in serum iPTH of 30% or more, but did not reach the primary end point. Compared to non-responders, responders were significantly older (p=0.026), female (p=0.041), and diabetics (p<0.001). Additionally, early response was observed more frequently in the responders (30/47, 63.8%), of whom the majority (27/30, 90.0%) achieved the primary end point. Multivariate analysis showed that lower baseline iPTH levels [odds ratio (OR) 0.96, 95% confidence interval (CI) 0.93-0.99], the presence of diabetes (OR 46.45, CI 1.92-1125.6) and early response (OR 21.54, CI 2.94-157.7) were significant clinical factors affecting achievement of iPTH target. CONCLUSION: Cinacalcet was effective in most hemodialysis patients with refractory SHPT. The presence of an early response was closely associated with the achievement of target levels of iPTH. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Biomarkers, Pharmacological/blood | - |
dc.subject.MESH | Calcium/blood | - |
dc.subject.MESH | Cinacalcet Hydrochloride | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hyperparathyroidism, Secondary/drug therapy* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Naphthalenes/adverse effects | - |
dc.subject.MESH | Naphthalenes/therapeutic use* | - |
dc.subject.MESH | Parathyroid Hormone/blood* | - |
dc.subject.MESH | Renal Dialysis* | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Rapid Decrease of Intact Parathyroid Hormone Could Be a Predictor of Better Response to Cinacalcet in Hemodialysis Patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Jwa-Kyung Kim | - |
dc.contributor.googleauthor | Young Joo Kwon | - |
dc.contributor.googleauthor | Soo Wan Kim | - |
dc.contributor.googleauthor | Yeong-Hoon Kim | - |
dc.contributor.googleauthor | Cheol Whee Park | - |
dc.contributor.googleauthor | Kyu Bok Choi | - |
dc.contributor.googleauthor | Seung Duk Hwang | - |
dc.contributor.googleauthor | Kyu Hun Choi | - |
dc.identifier.doi | 10.3349/ymj.2013.54.2.453 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04043 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 23364981 | - |
dc.subject.keyword | Cinacalcet | - |
dc.subject.keyword | end-stage renal disease | - |
dc.subject.keyword | hemodialysis | - |
dc.subject.keyword | parathyroid hormone | - |
dc.subject.keyword | secondary hyperparathyroidism | - |
dc.contributor.alternativeName | Choi, Kyu Hun | - |
dc.contributor.affiliatedAuthor | Choi, Kyu Hun | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 54 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 453 | - |
dc.citation.endPage | 463 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.54(2) : 453-463, 2013 | - |
dc.identifier.rimsid | 28888 | - |
dc.type.rims | ART | - |
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