590 553

Cited 16 times in

Myocardial protection by glucose–insulin–potassium in acute coronary syndrome patients undergoing urgent multivessel off-pump coronary artery bypass surgery

DC Field Value Language
dc.contributor.author곽영란-
dc.contributor.author심재광-
dc.contributor.author유경종-
dc.contributor.author유영철-
dc.date.accessioned2014-12-18T08:25:00Z-
dc.date.available2014-12-18T08:25:00Z-
dc.date.issued2013-
dc.identifier.issn0007-0912-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/86265-
dc.description.abstractBACKGROUND: The aim of this randomized and controlled trial was to investigate the effect of a glucose-insulin-potassium (GIK) solution on myocardial protection in acute coronary syndrome (ACS) patients undergoing urgent multivessel off-pump coronary artery bypass (OPCAB) surgery. METHODS: Sixty-six patients were randomly allocated either to receive 0.3 ml kg(-1) h(-2) GIK solution (potassium 80 mEq and regular insulin 325 IU in 500 ml of 50% glucose) or equivalent volume of normal saline (control) upon anaesthetic induction until 6 h after reperfusion. The primary endpoints were to compare the concentrations of creatine kinase-MB (CK-MB) and troponin-T between the groups after reperfusion. The secondary endpoints were to compare the incidences of postoperative troponin-T >0.8 ng ml(-1) and myocardial infarction (MI) between the groups. RESULTS: Highest CK-MB [8.7 (4.4) vs 13.1 (7.9) ng ml(-1), P=0.006] and troponin-T [0.20 (0.13-0.49) vs 0.48 (0.18-0.91) ng ml(-1), P<0.0001] values after reperfusion were significantly lower in the GIK group compared with the control group. The area under the curve of serially measured troponin-T was also significantly smaller in the GIK group compared with the control group [0.83 (0.43-1.81) vs 0.46 (0.31-1.00), P=0.036]. Significantly fewer patients in the GIK group showed troponin-T >0.8 ng ml(-1) after reperfusion compared with the control group (3 vs 11, P=0.033). The incidence of postoperative MI was similar between the groups. CONCLUSIONS: GIK administration in ACS patients undergoing urgent multivessel OPCAB significantly attenuated the degree of ensuing myocardial injury without complications related to glycaemic control. Clinical Trial Registry. URL: http://clinicaltrials.gov/ct2/show/NCT01384656?term=GIK+AND+OPCAB&rank=1. Unique identification number NCT01384656.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfBRITISH JOURNAL OF ANAESTHESIA-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAcute Coronary Syndrome/surgery*-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHCardiotonic Agents*-
dc.subject.MESHComorbidity-
dc.subject.MESHCoronary Artery Bypass, Off-Pump*-
dc.subject.MESHCreatine Kinase, MB Form/blood-
dc.subject.MESHDouble-Blind Method-
dc.subject.MESHEndpoint Determination-
dc.subject.MESHFemale-
dc.subject.MESHGlucose/therapeutic use*-
dc.subject.MESHHumans-
dc.subject.MESHHypoglycemic Agents/therapeutic use*-
dc.subject.MESHInsulin/therapeutic use*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMyocardial Infarction/epidemiology-
dc.subject.MESHMyocardial Infarction/prevention & control-
dc.subject.MESHPerioperative Care-
dc.subject.MESHPostoperative Complications/epidemiology-
dc.subject.MESHPostoperative Complications/prevention & control-
dc.subject.MESHPotassium/therapeutic use*-
dc.subject.MESHTroponin T/blood-
dc.titleMyocardial protection by glucose–insulin–potassium in acute coronary syndrome patients undergoing urgent multivessel off-pump coronary artery bypass surgery-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology (마취통증의학)-
dc.contributor.googleauthorJ.-K. Shim-
dc.contributor.googleauthorS.-Y. Yang-
dc.contributor.googleauthorY.-C. Yoo-
dc.contributor.googleauthorK.-J. Yoo-
dc.contributor.googleauthorY.-L. Kwak-
dc.identifier.doi10.1093/bja/aes324-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00172-
dc.contributor.localIdA02205-
dc.contributor.localIdA02291-
dc.contributor.localIdA02453-
dc.contributor.localIdA02484-
dc.relation.journalcodeJ00405-
dc.identifier.eissn1471-6771-
dc.identifier.pmid22986417-
dc.subject.keywordAcute Coronary Syndrome/surgery*-
dc.subject.keywordAdult-
dc.subject.keywordAged-
dc.subject.keywordCardiotonic Agents*-
dc.subject.keywordComorbidity-
dc.subject.keywordCoronary Artery Bypass, Off-Pump*-
dc.subject.keywordCreatine Kinase, MB Form/blood-
dc.subject.keywordDouble-Blind Method-
dc.subject.keywordEndpoint Determination-
dc.subject.keywordFemale-
dc.subject.keywordGlucose/therapeutic use*-
dc.subject.keywordHumans-
dc.subject.keywordHypoglycemic Agents/therapeutic use*-
dc.subject.keywordInsulin/therapeutic use*-
dc.subject.keywordMale-
dc.subject.keywordMiddle Aged-
dc.subject.keywordMyocardial Infarction/epidemiology-
dc.subject.keywordMyocardial Infarction/prevention & control-
dc.subject.keywordPerioperative Care-
dc.subject.keywordPostoperative Complications/epidemiology-
dc.subject.keywordPostoperative Complications/prevention & control-
dc.subject.keywordPotassium/therapeutic use*-
dc.subject.keywordTroponin T/blood-
dc.contributor.alternativeNameKwak, Young Lan-
dc.contributor.alternativeNameShim, Jae Kwang-
dc.contributor.alternativeNameYoo, Kyung Jong-
dc.contributor.alternativeNameYoo, Young Chul-
dc.contributor.affiliatedAuthorKwak, Young Lan-
dc.contributor.affiliatedAuthorShim, Jae Kwang-
dc.contributor.affiliatedAuthorYoo, Kyung Jong-
dc.contributor.affiliatedAuthorYoo, Young Chul-
dc.rights.accessRightsfree-
dc.citation.volume110-
dc.citation.number1-
dc.citation.startPage47-
dc.citation.endPage53-
dc.identifier.bibliographicCitationBRITISH JOURNAL OF ANAESTHESIA, Vol.110(1) : 47-53, 2013-
dc.identifier.rimsid28879-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.