Cited 16 times in
Myocardial protection by glucose–insulin–potassium in acute coronary syndrome patients undergoing urgent multivessel off-pump coronary artery bypass surgery
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 곽영란 | - |
dc.contributor.author | 심재광 | - |
dc.contributor.author | 유경종 | - |
dc.contributor.author | 유영철 | - |
dc.date.accessioned | 2014-12-18T08:25:00Z | - |
dc.date.available | 2014-12-18T08:25:00Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0007-0912 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/86265 | - |
dc.description.abstract | BACKGROUND: The aim of this randomized and controlled trial was to investigate the effect of a glucose-insulin-potassium (GIK) solution on myocardial protection in acute coronary syndrome (ACS) patients undergoing urgent multivessel off-pump coronary artery bypass (OPCAB) surgery. METHODS: Sixty-six patients were randomly allocated either to receive 0.3 ml kg(-1) h(-2) GIK solution (potassium 80 mEq and regular insulin 325 IU in 500 ml of 50% glucose) or equivalent volume of normal saline (control) upon anaesthetic induction until 6 h after reperfusion. The primary endpoints were to compare the concentrations of creatine kinase-MB (CK-MB) and troponin-T between the groups after reperfusion. The secondary endpoints were to compare the incidences of postoperative troponin-T >0.8 ng ml(-1) and myocardial infarction (MI) between the groups. RESULTS: Highest CK-MB [8.7 (4.4) vs 13.1 (7.9) ng ml(-1), P=0.006] and troponin-T [0.20 (0.13-0.49) vs 0.48 (0.18-0.91) ng ml(-1), P<0.0001] values after reperfusion were significantly lower in the GIK group compared with the control group. The area under the curve of serially measured troponin-T was also significantly smaller in the GIK group compared with the control group [0.83 (0.43-1.81) vs 0.46 (0.31-1.00), P=0.036]. Significantly fewer patients in the GIK group showed troponin-T >0.8 ng ml(-1) after reperfusion compared with the control group (3 vs 11, P=0.033). The incidence of postoperative MI was similar between the groups. CONCLUSIONS: GIK administration in ACS patients undergoing urgent multivessel OPCAB significantly attenuated the degree of ensuing myocardial injury without complications related to glycaemic control. Clinical Trial Registry. URL: http://clinicaltrials.gov/ct2/show/NCT01384656?term=GIK+AND+OPCAB&rank=1. Unique identification number NCT01384656. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | BRITISH JOURNAL OF ANAESTHESIA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acute Coronary Syndrome/surgery* | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Cardiotonic Agents* | - |
dc.subject.MESH | Comorbidity | - |
dc.subject.MESH | Coronary Artery Bypass, Off-Pump* | - |
dc.subject.MESH | Creatine Kinase, MB Form/blood | - |
dc.subject.MESH | Double-Blind Method | - |
dc.subject.MESH | Endpoint Determination | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glucose/therapeutic use* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypoglycemic Agents/therapeutic use* | - |
dc.subject.MESH | Insulin/therapeutic use* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Myocardial Infarction/epidemiology | - |
dc.subject.MESH | Myocardial Infarction/prevention & control | - |
dc.subject.MESH | Perioperative Care | - |
dc.subject.MESH | Postoperative Complications/epidemiology | - |
dc.subject.MESH | Postoperative Complications/prevention & control | - |
dc.subject.MESH | Potassium/therapeutic use* | - |
dc.subject.MESH | Troponin T/blood | - |
dc.title | Myocardial protection by glucose–insulin–potassium in acute coronary syndrome patients undergoing urgent multivessel off-pump coronary artery bypass surgery | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology (마취통증의학) | - |
dc.contributor.googleauthor | J.-K. Shim | - |
dc.contributor.googleauthor | S.-Y. Yang | - |
dc.contributor.googleauthor | Y.-C. Yoo | - |
dc.contributor.googleauthor | K.-J. Yoo | - |
dc.contributor.googleauthor | Y.-L. Kwak | - |
dc.identifier.doi | 10.1093/bja/aes324 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00172 | - |
dc.contributor.localId | A02205 | - |
dc.contributor.localId | A02291 | - |
dc.contributor.localId | A02453 | - |
dc.contributor.localId | A02484 | - |
dc.relation.journalcode | J00405 | - |
dc.identifier.eissn | 1471-6771 | - |
dc.identifier.pmid | 22986417 | - |
dc.subject.keyword | Acute Coronary Syndrome/surgery* | - |
dc.subject.keyword | Adult | - |
dc.subject.keyword | Aged | - |
dc.subject.keyword | Cardiotonic Agents* | - |
dc.subject.keyword | Comorbidity | - |
dc.subject.keyword | Coronary Artery Bypass, Off-Pump* | - |
dc.subject.keyword | Creatine Kinase, MB Form/blood | - |
dc.subject.keyword | Double-Blind Method | - |
dc.subject.keyword | Endpoint Determination | - |
dc.subject.keyword | Female | - |
dc.subject.keyword | Glucose/therapeutic use* | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Hypoglycemic Agents/therapeutic use* | - |
dc.subject.keyword | Insulin/therapeutic use* | - |
dc.subject.keyword | Male | - |
dc.subject.keyword | Middle Aged | - |
dc.subject.keyword | Myocardial Infarction/epidemiology | - |
dc.subject.keyword | Myocardial Infarction/prevention & control | - |
dc.subject.keyword | Perioperative Care | - |
dc.subject.keyword | Postoperative Complications/epidemiology | - |
dc.subject.keyword | Postoperative Complications/prevention & control | - |
dc.subject.keyword | Potassium/therapeutic use* | - |
dc.subject.keyword | Troponin T/blood | - |
dc.contributor.alternativeName | Kwak, Young Lan | - |
dc.contributor.alternativeName | Shim, Jae Kwang | - |
dc.contributor.alternativeName | Yoo, Kyung Jong | - |
dc.contributor.alternativeName | Yoo, Young Chul | - |
dc.contributor.affiliatedAuthor | Kwak, Young Lan | - |
dc.contributor.affiliatedAuthor | Shim, Jae Kwang | - |
dc.contributor.affiliatedAuthor | Yoo, Kyung Jong | - |
dc.contributor.affiliatedAuthor | Yoo, Young Chul | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 110 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 47 | - |
dc.citation.endPage | 53 | - |
dc.identifier.bibliographicCitation | BRITISH JOURNAL OF ANAESTHESIA, Vol.110(1) : 47-53, 2013 | - |
dc.identifier.rimsid | 28879 | - |
dc.type.rims | ART | - |
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