Cited 29 times in
Leptin/Adiponectin Ratio Is an Independent Predictor of Mortality in Nondiabetic Peritoneal Dialysis Patients
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 유동은 | - |
dc.contributor.author | 유태현 | - |
dc.contributor.author | 강신욱 | - |
dc.contributor.author | 이미정 | - |
dc.contributor.author | 김승준 | - |
dc.contributor.author | 한대석 | - |
dc.contributor.author | 김좌경 | - |
dc.contributor.author | 한승혁 | - |
dc.contributor.author | 박정탁 | - |
dc.contributor.author | 오형중 | - |
dc.date.accessioned | 2014-12-18T08:24:28Z | - |
dc.date.available | 2014-12-18T08:24:28Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0896-8608 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/86248 | - |
dc.description.abstract | BACKGROUND: The leptin/adiponectin (L/A) ratio has been suggested to be an atherosclerotic index for diabetic patients and a useful marker of insulin resistance in patients with and without diabetes. Even though end-stage renal disease (ESRD) patients on peritoneal dialysis (PD) are well characterized by abnormal adipocytokine metabolism, the significance of alterations in the L/A ratio is largely unexplored in these patients. In this prospective study, we investigated the associations of leptin, adiponectin, and the L/A ratio with clinical outcomes in nondiabetic PD patients. METHODS: The study included 131 stable nondiabetic ESRD patients who had been on PD for more than 3 months. Serum leptin and adiponectin levels were determined at baseline. Mortality was evaluated over a 5-year follow-up period. RESULTS: During the follow-up period, 22 patients died (16.8%), including 10 (45.5%) as a result of cardiovascular disease. The L/A ratio showed a significant positive correlation with body mass index [BMI (r = 0.47, p < 0.001)], high-sensitivity C-reactive protein (r = 0.32, p < 0.001), and triglycerides (r = 0.43, p < 0.001). In addition, we observed significant inverse correlations between the L/A ratio and percentage lean body mass (r = -0.30, p = 0.001) and high-density lipoprotein cholesterol (r = -0.31, p = 0.001). In contrast to individual leptin and adiponectin levels, the L/A ratio was found to be independently associated with an increased mortality risk (relative risk: 1.15; 95% confidence interval: 1.05 to 1.27; p = 0.003) even after adjustments for age and BMI. CONCLUSIONS: The L/A ratio might be better related to patient outcomes than adipocytokines are individually in nondiabetic patients undergoing PD. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | PERITONEAL DIALYSIS INTERNATIONAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adiponectin/blood* | - |
dc.subject.MESH | Atherosclerosis/blood* | - |
dc.subject.MESH | Atherosclerosis/complications | - |
dc.subject.MESH | Atherosclerosis/mortality | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | Diabetes Mellitus | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kidney Failure, Chronic/blood | - |
dc.subject.MESH | Kidney Failure, Chronic/complications | - |
dc.subject.MESH | Kidney Failure, Chronic/therapy* | - |
dc.subject.MESH | Leptin/blood* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Peritoneal Dialysis/mortality* | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.subject.MESH | Survival Rate/trends | - |
dc.subject.MESH | Time Factors | - |
dc.title | Leptin/Adiponectin Ratio Is an Independent Predictor of Mortality in Nondiabetic Peritoneal Dialysis Patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Jung Tak Park | - |
dc.contributor.googleauthor | Tae-Hyun Yoo | - |
dc.contributor.googleauthor | Jwa-Kyung Kim | - |
dc.contributor.googleauthor | Hyung Jung Oh | - |
dc.contributor.googleauthor | Seung Jun Kim | - |
dc.contributor.googleauthor | Dong Eun Yoo | - |
dc.contributor.googleauthor | Mi Jung Lee | - |
dc.contributor.googleauthor | Dong Ho Shin | - |
dc.contributor.googleauthor | Seung Hyeok Han | - |
dc.contributor.googleauthor | Dae-Suk Han | - |
dc.contributor.googleauthor | Shin-Wook Kang | - |
dc.identifier.doi | 10.3747/pdi.2011.00066 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02461 | - |
dc.contributor.localId | A02526 | - |
dc.contributor.localId | A00053 | - |
dc.contributor.localId | A04272 | - |
dc.contributor.localId | A00931 | - |
dc.contributor.localId | A04304 | - |
dc.contributor.localId | A01654 | - |
dc.contributor.localId | A02097 | - |
dc.contributor.localId | A02417 | - |
dc.contributor.localId | A00659 | - |
dc.contributor.localId | A02773 | - |
dc.relation.journalcode | J02500 | - |
dc.identifier.eissn | 1718-4304 | - |
dc.identifier.pmid | 22855891 | - |
dc.subject.keyword | Leptin | - |
dc.subject.keyword | adiponectin | - |
dc.subject.keyword | mortality | - |
dc.subject.keyword | inflammation | - |
dc.contributor.alternativeName | Yoo, Dong Eun | - |
dc.contributor.alternativeName | Yoo, Tae Hyun | - |
dc.contributor.alternativeName | Kang, Shin Wook | - |
dc.contributor.alternativeName | Lee, Mi Jung | - |
dc.contributor.alternativeName | Kim, Seung Jun | - |
dc.contributor.alternativeName | Han, Dae Suk | - |
dc.contributor.alternativeName | Kim, Jwa Kyung | - |
dc.contributor.alternativeName | Han, Seung Hyeok | - |
dc.contributor.alternativeName | Park, Jung Tak | - |
dc.contributor.alternativeName | Shin, Dong Ho | - |
dc.contributor.alternativeName | Oh, Hyung Jung | - |
dc.contributor.affiliatedAuthor | Yoo, Dong Eun | - |
dc.contributor.affiliatedAuthor | Yoo, Tae Hyun | - |
dc.contributor.affiliatedAuthor | Kang, Shin Wook | - |
dc.contributor.affiliatedAuthor | Han, Dae Suk | - |
dc.contributor.affiliatedAuthor | Kim, Jwa Kyung | - |
dc.contributor.affiliatedAuthor | Han, Seung Hyeok | - |
dc.contributor.affiliatedAuthor | Park, Jung Tak | - |
dc.contributor.affiliatedAuthor | Shin, Dong Ho | - |
dc.contributor.affiliatedAuthor | Oh, Hyung Jung | - |
dc.contributor.affiliatedAuthor | Kim, Seung Jun | - |
dc.contributor.affiliatedAuthor | Lee, Mi Jung | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 33 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 67 | - |
dc.citation.endPage | 74 | - |
dc.identifier.bibliographicCitation | PERITONEAL DIALYSIS INTERNATIONAL, Vol.33(1) : 67-74, 2013 | - |
dc.identifier.rimsid | 28871 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.