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Expression of autophagy-related markers beclin-1, light chain 3A, light chain 3B and p62 according to the molecular subtype of breast cancer

DC FieldValueLanguage
dc.contributor.author구자승-
dc.contributor.author정우희-
dc.date.accessioned2014-12-18T08:22:32Z-
dc.date.available2014-12-18T08:22:32Z-
dc.date.issued2013-
dc.identifier.issn0309-0167-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/86189-
dc.description.abstractAIMS: To investigate the relationship between the expression of autophagy-related proteins, including beclin-1, light chain (LC) 3A, LC3B, and p62, and prognosis in invasive breast cancer. METHODS AND RESULTS: We constructed tissue microarrays from the breast cancer cells of 489 patients, and classified molecular subtypes using surrogate immunohistochemical stains. The tumoral expression levels of LC3A and LC3B were highest in triple-negative breast cancer (TNBC) (P < 0.001), whereas these types of tumour had the lowest expression levels of these markers in the stroma (P = 0.005 and P < 0.001, respectively). Cytoplasmic beclin-1 expression was highest in TNBC, but nuclear expression was lowest (P < 0.001). p62 cytoplasmic and nuclear expression were highest in HER2-type tumours (P = 0.001 and P < 0.001, respectively). Tumoral LC3A and LC3B expression were associated with high histological grade (P < 0.001, and P < 0.028, respectively), but nuclear p62 expression was associated with lower histological grade (P = 0.004). CONCLUSIONS: Autophagy-related markers are differentially expressed according to the molecular subtype of breast cancer. In particular, expression of LC3A, LC3B and beclin-1 was highest in TNBC tumour cells, whereas that of LC3A and LC3B in the tumour stroma was lowest in TNBC.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfHISTOPATHOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleExpression of autophagy-related markers beclin-1, light chain 3A, light chain 3B and p62 according to the molecular subtype of breast cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorJunjeong Choi-
dc.contributor.googleauthorWoohee Jung-
dc.contributor.googleauthorJa Seung Koo-
dc.identifier.doi10.1111/his.12002-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00198-
dc.contributor.localIdA03671-
dc.relation.journalcodeJ00994-
dc.identifier.eissn1365-2559-
dc.identifier.pmidautophagy ; breast cancer ; immunohistochemistry ; molecu lar subtype-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/his.12002/abstract-
dc.subject.keywordautophagy-
dc.subject.keywordbreast cancer-
dc.subject.keywordimmunohistochemistry-
dc.subject.keywordmolecu lar subtype-
dc.contributor.alternativeNameKoo, Ja Seung-
dc.contributor.alternativeNameJung, Woo Hee-
dc.contributor.affiliatedAuthorKoo, Ja Seung-
dc.contributor.affiliatedAuthorJung, Woo Hee-
dc.contributor.affiliatedAuthor구자승-
dc.rights.accessRightsnot free-
dc.citation.volume62-
dc.citation.number2-
dc.citation.startPage275-
dc.citation.endPage286-
dc.identifier.bibliographicCitationHISTOPATHOLOGY, Vol.62(2) : 275-286, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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