Cited 18 times in
The expression of metabolism-related proteins in phyllodes tumors
DC Field | Value | Language |
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dc.contributor.author | 구자승 | - |
dc.contributor.author | 정우희 | - |
dc.date.accessioned | 2014-12-18T08:22:28Z | - |
dc.date.available | 2014-12-18T08:22:28Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1010-4283 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/86187 | - |
dc.description.abstract | The purpose of this study was to investigate the association between the expression of hypoxia-inducible factor (HIF)-1α, insulin-like growth factor (IGF)-1, glucose transporter 1 (Glut-1), carbonic anhydrase IX (CAIX), and monocarboxylate transporter (MCT)4, which are metabolism-related proteins in phyllodes tumors (PTs), and clinicopathologic factors and its implication. We used tissue microarrays to analyze 207 PTs and performed immunohistochemical staining against the glycolysis-related molecules HIF-1α, IGF-1, Glut-1, CAIX, and MCT4. We then compared the immunohistochemical results and clinicopathologic parameters. The expressions of HIF-1α, Glut-1, CAIX, and MCT4 in the stromal component of PTs increased (P = 0.019, P < 0.001, P = 0.045, and P < 0.001, respectively) with increasing tumor grade. According to univariate analysis, factors associated with shorter disease-free survival were Glut-1 expression (P = 0.001) and MCT4 expression (P < 0.001) in the stromal component, and the factors associated with shorter overall survival were IGF-1 expression (P = 0.012), Glut-1 expression (P < 0.001), CAIX expression (P = 0.039), and MCT4 expression (P < 0.001) in the stromal component. Our investigation of stromal expression of the metabolism-related proteins HIF-1α, IGF-1, Glut-1, CAIX, and MCT4 revealed that, as the PT grade increased, the stromal expression of HIF-1α, Glut-1, CAIX, and MCT4 significantly increased. This result suggested that increasing PT grade is associated with increased glycolysis in the stromal component. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | TUMOR BIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Antigens, Neoplasm/metabolism | - |
dc.subject.MESH | Biomarkers, Tumor/metabolism | - |
dc.subject.MESH | Breast Neoplasms/metabolism* | - |
dc.subject.MESH | Breast Neoplasms/mortality | - |
dc.subject.MESH | Carbonic Anhydrase IX | - |
dc.subject.MESH | Carbonic Anhydrases/metabolism | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Energy Metabolism* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glucose Transporter Type 1/metabolism | - |
dc.subject.MESH | Glycolysis | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypoxia-Inducible Factor 1, alpha Subunit/metabolism | - |
dc.subject.MESH | Insulin-Like Growth Factor I/metabolism | - |
dc.subject.MESH | Monocarboxylic Acid Transporters/metabolism | - |
dc.subject.MESH | Muscle Proteins/metabolism | - |
dc.subject.MESH | Neoplasm Grading | - |
dc.subject.MESH | Phyllodes Tumor/metabolism* | - |
dc.subject.MESH | Survival | - |
dc.title | The expression of metabolism-related proteins in phyllodes tumors | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Ji Eun Kwon | - |
dc.contributor.googleauthor | Woo-Hee Jung | - |
dc.contributor.googleauthor | Ja Seung Koo | - |
dc.identifier.doi | 10.1007/s13277-012-0518-9 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00198 | - |
dc.contributor.localId | A03671 | - |
dc.relation.journalcode | J02763 | - |
dc.identifier.eissn | 1423-0380 | - |
dc.identifier.pmid | 22986897 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs13277-012-0518-9 | - |
dc.subject.keyword | Breast | - |
dc.subject.keyword | Metabolism | - |
dc.subject.keyword | Phyllodes tumor | - |
dc.contributor.alternativeName | Koo, Ja Seung | - |
dc.contributor.alternativeName | Jung, Woo Hee | - |
dc.contributor.affiliatedAuthor | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | Jung, Woo Hee | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 34 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 115 | - |
dc.citation.endPage | 124 | - |
dc.identifier.bibliographicCitation | TUMOR BIOLOGY, Vol.34(1) : 115-124, 2013 | - |
dc.identifier.rimsid | 28837 | - |
dc.type.rims | ART | - |
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