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Comparison of early strut coverage between zotarolimus- and everolimus-eluting stents using optical coherence tomography

Authors
 Seunghwan Kim  ;  Jung-Sun Kim  ;  Dong-Ho Shin  ;  Byeong-Keuk Kim  ;  Young-Guk Ko  ;  Donghoon Choi  ;  Yun-Kyeong Cho  ;  Chang-Wook Nam  ;  Seung-Ho Hur  ;  Yangsoo Jang  ;  Myeong-Ki Hong 
Citation
 American Journal of Cardiology, Vol.111(1) : 1-5, 2013 
Journal Title
 American Journal of Cardiology 
ISSN
 0002-9149 
Issue Date
2013
Abstract
There have been no optical coherence tomographic (OCT) data directly comparing the pattern of strut coverage between the 2 second-generation drug-eluting stents in the early period. The aim of this prospective study was to evaluate early strut coverage using optical coherence tomography 3 months after Resolute zotarolimus-eluting stent (ZES-R) or everolimus-eluting stent (EES) implantation in de novo coronary artery lesions. A total of 40 patients who were suitable for the OCT procedure and consented to the study protocol were randomized 1:1 to receive either ZES-R or EES. Among these patients, 35 stented lesions (18 ZES-R, 17 EES) in 34 patients were evaluated by optical coherence tomography immediately and 3 months after stent implantation. Neointimal hyperplasia thickness, percentage of uncovered struts, and the proportion of malapposed struts were measured at 1-mm intervals. An uncovered strut was defined as having a neointimal hyperplasia thickness of 0 μm. At the 3-month OCT evaluation, mean neointimal hyperplasia thickness (ZES-R vs EES 74 ± 41 vs 75 ± 35 μm, p = 0.89) and mean percentage of uncovered struts (ZES-R vs EES 6.2 ± 6.9 vs 4.7 ± 5.1%, p = 0.62) were not significantly different between the groups. The percentage of malapposed struts was also similar between the groups (0.7 ± 2.2% for ZES-R and 0.7 ± 1.7% for EES, p = 0.64). Thrombi were documented in 3 stents (1 [5.6%] in a ZES-R vs 2 [11.8%] in EES, p = 0.60). In conclusion, early stent strut coverage on the basis of serial OCT evaluation was comparable between ZES-R and EES 3 months after stent implantation
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86160
DOI
10.1016/j.amjcard.2012.08.037
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
고영국(Ko, Young Guk)
김병극(Kim, Byeong Keuk)
김승환(Kim, Seung Hwan)
김중선(Kim, Jung Sun)
신동호(Shin, Dong Ho)
장양수(Jang, Yang Soo)
최동훈(Choi, Dong Hoon)
홍명기(Hong, Myeong Ki)
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Full Text
http://www.sciencedirect.com/science/article/pii/S0002914912020541
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