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Modification of TiO(2) nanotube surfaces by electro-spray deposition of amoxicillin combined with PLGA for bactericidal effects at surgical implantation sites

Authors
 Jung-Hwan Lee ; Seung-Kyun Moon ; Kyoung-Nam Kim ; Kwang-Mahn Kim 
Citation
 Acta Odontologica Scandinavica, Vol.71(1) : 168~174, 2013 
Journal Title
 Acta Odontologica Scandinavica 
ISSN
 0001-6357 
Issue Date
2013
Abstract
OBJECTIVE: To fabricate the antibiotic-releasing coatings on TiO(2) nanotube surfaces for wide applications of implant and bone plate in medical and dental surgery, the optimal deposition time of amoxicillin/PLGA solution simultaneously performing non-toxicity and a high bactericidal effect for preventing early implant failures was found. MATERIALS AND METHODS: FE-SEM, ESD and FT-IR were used for confirming deposition of amoxicillin/PLGA on the TiO(2) surface. Also, the elution of amoxicillin/PLGA in a TiO(2) nanotube surface was measured by a UV-VIS spectrophotometer. The bactericidal effect of amoxicillin on the TiO(2) nanotube surface was evaluated by using Staphylococcus aureus (S. aureus). The cytotoxicity and cell proliferation were observed by WST assay using MC3T3-E1 osteoblast cells. RESULTS: The results indicated that the TiO(2) nanotube surface controlled by electro-spray deposition time with amoxicillin/PLGA solution could provide a high bactericidal effect against S. aureus by the bactericidal effect of amoxicillin, as well as good osteoblast cell proliferation at the TiO(2) nanotube surface without toxicity. CONCLUSIONS: This study used electro-spray deposition (ESD) methodology to obtain amoxicillin deposition in nanotube structures of TiO(2) and found the optimal deposition time of amoxicillin/PLGA solution simultaneously performing non-toxicity and a high bactericidal effect for preventing early implant failures
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/86125
DOI
10.3109/00016357.2011.654256
Appears in Collections:
1. 연구논문 > 2. College of Dentistry > Dept. of Dental Engineering
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Link
 http://informahealthcare.com/doi/abs/10.3109/00016357.2011.654256
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