Compensatory hypertrophy of the superior gluteus maximus following botulinum toxin-induced weakening of the inferior fibers

Abstract

Selective chemodenervation of the inferior gluteus maximus (GMax) may induce compensatory hypertrophy of its superior fibers. Two healthy female subjects underwent ultrasound-guided botulinumtoxinA (JETEMA THE TOXIN, JETEMA Co., Ltd., Korea) injections (100 IU) into the inferior GMax. Six-week follow-up revealed increased fullness and definition in the superior region without adverse effects. The observation supports the concept that targeted muscle weakening can promote adaptive hypertrophy in adjacent fibers. This minimally invasive approach may have poten tial applications in aesthetic body contouring and functional rehabilitation. (c) 2025 The Authors. Published by Elsevier Ltd on behalf of British Association of Plastic, Reconstructive and Aesthetic Surgeons. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)